Summary
During the period 1947–1956, 148 patients underwent extrapleural pneumolysis for pulmonary tuberculosis in Stockholm City Chest Hospital at Söderby. In 121 tuberculosis healed following operation. Ten of these later developed pain and a feeling of tension on the operated side and were operated upon with evacuation of the extrapleural sac. In four of them a highly differentiated keratinizing squamous cell carcinoma had developed. In addition, two more cases of carcinomas of the same type operated on at other hospitals are described. Five of the six patients died of cancer. Squamous cell carcinoma occurring in metaplastic mesothelial cells has hitherto not been reported on and the phenomenon is discussed and compared with the more common scar cancers within lung tissue caused by damage from tuberculosis.
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References
Baló, J., Jullasz, E., Temes, J.: Pulmonary infarcts and pulmonary carcinoma. Cancer (Philad.) 9; 918–922 (1956)
Barnard, W. G., Day, T. D.: The development of the terminal air passages of the human lung. J. Path. Bact. 45, 67–73 (1937)
Berglund, S., Linell, F.: Fibrosis and carcinoma of the lung in a family with hemoglobin Malmö. Scand. J. Haemat. 9, 424–432 (1972)
Berkheiser, S. W.: Bronchiolar proliferation and metaplasia associated with bronchiectasis, pulmonary infarcts and antracosis. Cancer (Philad.) 12, 499–508 (1959)
Berkheiser, S. W.: Bronchiolar proliferation and metaplasia associated with trombembolism. Cancer (Philad.) 16, 205–211 (1963)
Bruce, T., Dahlström, G., Uggla, L. G.: Squamous epithelial cancer of the pleura following extrapleural pneumothorax for pulmonary tuberculosis. Acta tuberc. scand. 38, 261–266 (1960)
Campbell, W. N.: Pleural mesothelioma. Amer. J. Path. 26, 473–487 (1950)
Carrol, R.: The influence of lung scars on primary lung cancer. J. Path. Bact. 832, 93–297 (1962)
Goodwin, M. C.: Diffuse mesotheliomas; with comment on their relation to localized fibrous mesotheliomas. Cancer (Philad.) 10, 298–319 (1957)
Heppleston, A. G.: The pathology of honeycomb lung. Thorax 11, 77–93 (1956)
King, L. S.: Atypical proliferation of bronchiolar epithelium. Arch. Path. 58, 59–70 (1954)
Klemperer, P., Rabin, C. B.: Primary neoplasms of the pleura. A report of five cases. Arch. Path. 11, 385–412 (1931)
Liebow, A. A.: In AMP Atlas of Tumour Pathology: Sect. V. fasc. 17: Tumours of the lower respiratory tract, p. 177. Washington DC 1952
Meyer, E. C., Liebow, A. A.: Relationship of interstitial pneumonia, honeycombing and atypical proliferation to cancer of the lung. Cancer (Philad.) 18, 322–351 (1965)
National Board of Health and Welfare: The cancer registry. Cancer incidence in Sweden 1959–1965
Raeburn, C., Spencer, H.: Lung scar cancers. Brit. J. Tuberc. 51, 237–245 (1957)
Robertson, H. E.: Endothelioma of the pleura. J. Cancer Res. 8, 317–375 (1924)
Rössle, R.: Die Narben-Krebse der Lungen. Schweiz. med. Wschr. 73, 1200–1203 (1973)
Spencer, H.: Pathology of the lung. Oxford: Pergamon Press 1968
Stout, A. P., Murray, Margaretha, R.: Localized pleural mesothelioma. Investigation of its characteristics and histogenesis by the method of tissue culture. Arch. Path. 34, 951–964 (1942)
Themel, K. G., Lüders, C. J.: Die Bedeutung tuberculose Narben für Entstehung des periferen Lungenkarzinoms. — Ein Beitrag zum Krankheitsbild des Lungennarben-Krebses. Deutsch. Med. Wschr. 80, 1360–1363 (1955)
Willis, R. A.: A metaplastic deposit of bronichal carcinoma in a hydrocele missdiagnosed “endothelioma.” J. Path. Bact. 47, 35–42 (1938)
Yokoo, H., Suckow, E. E.: Peripheral lung cancers arising in scars. Cancer (Philad.) 14, 1205–1215 (1961)
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Supported by the Swedish National Association against Heart and Chest Diseases
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Willén, R., Bruce, T., Dahlström, G. et al. Squamous epithelial cancer in metaplastic pleura following extrapleural pneumothorax for pulmonary tuberculosis. Virchows Arch. A Path. Anat. and Histol. 370, 225–231 (1976). https://doi.org/10.1007/BF00427582
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DOI: https://doi.org/10.1007/BF00427582