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Mapping of multiple mouse loci related to the farnesyl pyrophosphate synthetase gene

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Abstract

The prenyltransferases are a class of enzymes involved in the synthesis of sterol and nonsterol isoprene compounds. We report here the chromosomal mapping of nine loci in the mouse that hybridize to the cDNA for the enzyme farnesyl pyrophosphate synthetase (FPS), a prenyltransferase that catalyzes the synthesis of an intermediate common to both the sterol and nonsterol branches of the isoprene biosynthetic pathway. Mapping was performed with genomic DNA from a mouse-hamster somatic cell hybrid panel, and by linkage analysis with recombinant inbred strains and the progeny of an interspecific backcross. The mapped loci have been designated farnesyl pyrophosphate synthetase-like-1 (Fpsl-1) on mouse Chromosome (Chr) 3; Fpsl-2 on Chr 4; Fpsl-3, Fpsl-4, and Fpsl-5, dispersed on Chr 10; Fpsl-6 on Chr 12; Fpsl-7 on Chr 13; Fpsl-8 on Chr 17; and Fpsl-9 on Chr X. It is presently unclear which of these loci encode active prenyltransferases and which may correspond to pseudogenes. The strongly hybridizing loci provide convenient genetic markers for seven mouse chromosomes.

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Authors and Affiliations

  1. Department of Medicine and Department of Microbiology and Molecular Genetics, University of California, 47-123 Center for Health Sciences, 90024, Los Angeles, California, USA

    Ali Andalibi, Anh Diep, Diana Quon & Aldons J. Lusis

  2. Division of Medical Genetics, Harbor-UCLA Medical Center, 90509, Torrance, California, USA

    Thuluvancheri Mohandas

  3. The Jackson Laboratory, 04609, Bar Harbor, Maine, USA

    Benjamin A. Taylor

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  1. Ali Andalibi
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  2. Anh Diep
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  4. Thuluvancheri Mohandas
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Andalibi, A., Diep, A., Quon, D. et al. Mapping of multiple mouse loci related to the farnesyl pyrophosphate synthetase gene. Mammalian Genome 4, 211–219 (1993). https://doi.org/10.1007/BF00417565

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