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A comparative study of the inhibitory effects of haloperidol and trifluperidol on learned shock-avoidance behavioural habits and on apomorphine-induced emesis in mongrel dogs and in beagles

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Summary

In dogs trifluperidol is about 3 times more active than haloperidol as an antagonist of apomorphine-induced emesis, whereas as an inhibitor of learned conditioned shock-avoidance behavioural habits (jumping box test), trifluperidol is only about 1 1/2 times more active than haloperidol.

In both tests, however, haloperidol is somewhat faster acting and significantly longer acting than trifluperidol.

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References

  • Janssen, P. A. J., and C. J. E. Niemegeers: Chemistry and pharmacology of compounds related to 4-(4-hydroxy-4-phenyl-piperidino)-butyro-phenone. Part II. Inhibition of apomorphine vomiting in dogs. Arzneimittel-Forsch. 9, 765 to 767 (1959).

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  • Niemegeers, C. J. E., and P. A. J. Janssen: Influence of haloperidol (R 1625) and of haloperidide (R 3201) on avoidance and escape behaviour of trained dogs in a “jumping box”. J. Pharm. Pharmacol. 12, 744–753 (1960).

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Authors and Affiliations

  1. Research Laboratories, Janssen Pharmaceutica N. V., Beerse, Belgium

    Carlos J. E. Niemegeers & Paul A. J. Janssen

Authors
  1. Carlos J. E. Niemegeers
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  2. Paul A. J. Janssen
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Niemegeers, C.J.E., Janssen, P.A.J. A comparative study of the inhibitory effects of haloperidol and trifluperidol on learned shock-avoidance behavioural habits and on apomorphine-induced emesis in mongrel dogs and in beagles. Psychopharmacologia 8, 263–270 (1965). https://doi.org/10.1007/BF00407858

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  • DOI: https://doi.org/10.1007/BF00407858

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