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Does interleukin-1 mediate tumour necrosis factor alpha-induced fever in rabbits?

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Abstract

We investigated the humoral mechanisms involved in tumour necrosis factor alpha (TNFα)-induced fever in rabbits. No change in lymphocyte-activating factor activity was detected in serum drawn during TNFα-induced fever. The pyrogenic activity of recombinant rabbit interleukin-1β (IL-1β) was entirely abolished by pre-incubation with anti-IL-1β antiserum from the goat. Fever induced by intravenous (i.v.) injection of IL-1β was significantly diminished by i.v. infusion of the antiserum. However, i.v. infusion of the antiserum for 1 h did not affect fever induced by i.v. injection of TNFα, when the antiserum infusion began either simultaneously with, or 2 h after, the injection of TNFα. Furthermore, intracerebroventricular injection of the antiserum did not affect TNFα-induced fever. The intracerebroventricular administration of naloxone (an opioid receptor antagonist) significantly diminished TNFα-induced fever. The results suggest that IL-1, both in the blood circulation and in the brain, may not be involved in TNFα-induced fever. Similar to the contribution of eicosanoids, the opioid system in the brain seems some-how to contribute to the mechanism of the development of fever induced by TNFα in rabbits.

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Author notes

  1. Masaaki Hashimoto

    Present address: Max-Planck-Institut, Parkstrasse 1, D-61231, Bad Nauheim, Germany

Authors and Affiliations

  1. Department of Physiology, Yamanashi Medical University, Tamaho, Nakakoma, 409-38, Yamanashi, Japan

    Masaaki Hashimoto, Yoichi Sakakibara & Masami Iriki

  2. Department of Pathology, Kumamoto University Medical School, 860, Kumamoto, Japan

    Fumimasa Goto

  3. Department of Physiology and Pathology, National Institute of Radiological Sciences, 260, Chiba, Japan

    Yoshiya Shimada

Authors
  1. Masaaki Hashimoto
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  2. Yoichi Sakakibara
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  4. Fumimasa Goto
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  5. Yoshiya Shimada
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Hashimoto, M., Sakakibara, Y., Iriki, M. et al. Does interleukin-1 mediate tumour necrosis factor alpha-induced fever in rabbits?. Pflügers Arch 427, 365–372 (1994). https://doi.org/10.1007/BF00374546

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  • DOI: https://doi.org/10.1007/BF00374546

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