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Effects of topical cyclosporin A on guinea-pig toxic contact dermatitis

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Summary

It is known that the topical application of cyclosporin A (CsA) has a significant suppressive effect on allergic contact dermatitis. In this study, we investigated the effect of topical CsA on toxic (non-allergic) contact dermatitis. Topical CsA significantly suppressed the toxic contact reaction to croton oil. This suppressive effect was short-lived and reversible. Significant inhibition of the reaction to croton oil persisted for 3 days after stopping the CsA. The toxic reaction was blocked when CsA was applied within 6 h of the croton oil application, but when application of CsA was delayed until 12 h after the oil application there was no significant suppressive effect. Topical administration of CsA could become a valuable tool for treating toxic and allergic contact dermatitis without producing the adverse reactions caused by systemic therapy.

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References

  1. Anderson C (1985) The effect of selected immunomodulating agents on experimental contact reactions. Acta Derm Venereol [Suppl] (Stockh) 116:1–48

    Google Scholar 

  2. Anderson C, Groth O (1985) Suppression of allergic contact reaction in the guinea pig by cyclosporin A. Int Arch Allergy Appl Immunol 78:396–400

    Google Scholar 

  3. Biren CA, Barr RJ (1986) Dermatological application of cyclosporine. Arch Dermatol 122:1028–1032

    Google Scholar 

  4. Biren C, Ganderup G, Lemus L, Mc-Cullough J, Barr R (1984) Topical cyclosporine (CSA): effect on contact dermatitis in guinea pigs. J Invest Dermatol 82:419

    Google Scholar 

  5. Borel JF, Feurer C, Magnee C, Stahelin H (1977) Effects of the new anti-lymphocytic peptide cyclosporin A in animals. Immunology 32:1017–1025

    Google Scholar 

  6. Braida M, Knop J (1986) Effect of cyclosporin A on the T-effector and T-suppressor cell response in contact sensitivity. Immunology 59:503–507

    Google Scholar 

  7. Brestel EP, Van Dyke K (1986) Lipid mediator of homeostasis and inflammation. In: Craig CR, Stitzel RE (eds) Modern pharmacology. Little, Brown, Boston, pp 247–256

    Google Scholar 

  8. Gschwendt M, Kittstein W, Horn F, Marks F (1985) Cyclosporin A inhibits biological effects of tumor promoting phorbol ester. Biochem Biophys Res Commun 126:327–332

    Google Scholar 

  9. Gschwendt M, Kittstein W, Marks F (1988) The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EFG-2 phosphorylation in vitro. Biophys Res Commun 150:545–551

    Google Scholar 

  10. Iwatuki S, Starzl TE, Shaw BW, Yang SL, Zitelli BJ, Gartner JC, Malatack JJ (1983) Long-term use of cyclosporine in liver recipients. Transplantation 36:641–643

    Google Scholar 

  11. Morris PJ (1981) Cyclosporin A. Transplantation 32:349–354

    Google Scholar 

  12. Nakagawa S, Oka D, Jinno Y, Takey Y, Bang D, Ueki H (1988) Topical application of cyclosporine on guinea pig allergic contact dermatitis. Arch Dermatol 124:907–910

    Google Scholar 

  13. Niwa Y, Kano T, Taniguchi S, Miyachi Y, Sakane T (1986) Effect of cyclosporin A on the membrane associated events in human leukocytes with special reference to the similarity with dexamethasone. Biochem Pharmacol 35:947–951

    Google Scholar 

  14. Rullan PP, Barr RJ, Cole GW (1984) Cyclosporine and murine allergic contact dermatitis. Arch Dermatol 120:1179–1183

    Google Scholar 

  15. Shevach EM (1985) The effects of cyclosporin A on the immune system. Ann Rev Immunol 3:397–423

    Google Scholar 

  16. Thivolet J, Barthelemy H, Rigot-Muller G, Bendelac A (1985) Effect of cyclosporine on bullous pemphigoid and pemphigus. Lancet II:334–335

    Google Scholar 

  17. Tilney NL, Milford EL, Araujo J, Strom TB, Carpenter CB, Kirkman RL (1984) Experience with cyclosporine and steroids in clinical renal transplantation. Ann Surg 200:605–613

    Google Scholar 

  18. Van Joost T, Stolz E, Heule F (1987) Efficacy of low-dose cyclosporine in severe atopic skin disease. Arch Dermatol 123:166–167

    Google Scholar 

  19. Xue B, Dersarkissian RM, Baer RL, Thorbecke J, Belsito DV (1986) Reversal by lymphokines of the effect of cyclosporin A on contact sensitivity and antibody production in mice. J Immunol 136:4128–4133

    Google Scholar 

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Authors and Affiliations

  1. Department of Dermatology, Kawasaki Medical School, 577, Matsushima, 701-01, Kurashiki, Japan

    M. Yokoo, D. Oka & S. Nakagawa

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  1. M. Yokoo
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  2. D. Oka
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  3. S. Nakagawa
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Yokoo, M., Oka, D. & Nakagawa, S. Effects of topical cyclosporin A on guinea-pig toxic contact dermatitis. Arch Dermatol Res 282, 408–411 (1990). https://doi.org/10.1007/BF00372093

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  • DOI: https://doi.org/10.1007/BF00372093

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