Abstract
In a retrospective study the incidence of infections, number of afebrile days, duration of antimicrobial chemotherapy, and cost of antibacterials and antimycotics were compared in two groups of patients. One was a group of 57 patients who received no prophylaxis during induction remission therapy of acute leukemia treated in 1989–1990, the second was a group of 22 patients treated in 1991 where prophylaxis with fluconazol and ofloxacin was administered. For ethical reasons pertaining since 1991, when prophylaxis became mandatory, the study was not randomized. A decrease in the number of febrile days, the cost of antimicrobials and the duration of treatment with antibiotics and antimycotics was observed in the group receiving fluconazol and ofloxacin.
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Šajben, P., Minárik, T., Tomášik, E. et al. Fluconazol plus ofloxacin in prophylaxis of infections in patients with acute leukemia: a comparative study. Support Care Cancer 1, 214–216 (1993). https://doi.org/10.1007/BF00366449
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DOI: https://doi.org/10.1007/BF00366449