Summary
We have studied the concentrations of ciprofloxacin in serum, bronchial mucosa, lung parenchyma, and pleural tissue after a single intravenous dose of 200 mg in 20 patients subjected to lung surgery.
The concentrations of ciprofloxacin in the tissues exceeded that in the serum by 3-fold to 7-fold: serum 0.6 μg·ml−1, bronchial mucosa 1.9 μg·g−1 lung parenchyma 3.4 μg·g−, and pleural tissue 1.7 μg·g−1.
The achievable concentrations of ciprofloxacin in the tissues of the lower respiratory tract are above the MICs for most lung pathogens.
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Dan, M., Torossian, K., Weissberg, D. et al. The penetration of ciprofloxacin into bronchial mucosa, lung parenchyma, and pleural tissue after intravenous administration. Eur J Clin Pharmacol 44, 101–102 (1993). https://doi.org/10.1007/BF00315290
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DOI: https://doi.org/10.1007/BF00315290