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Epidermal growth factor receptor content in rat prostatic adenocarcinoma: effects of endocrine treatment

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Abstract

Epidermal growth factor receptor (EGF-R) was studied in Dunning prostatic cancer models using competitive bindings assays and solution hybridization assay. EGF-R-binding capacity and mRNA were demonstrated in a hormone-sensitive R3327 prostatic tumor from both control and castrated animals while no such activity was found in the hormone-independent AT-1 tumors. Castration induced no quantitative changes in the EGF-R. Estrogen treatment induced a significant reduction of the binding capacity of EGF-R and its mRNA. It was concluded that EGF-R is present in the androgen-sensitive Dunning prostatic tumor models (R3327), but that the androgen-insensitive, undifferentiated AT-1 tumor lacks EGF-R expression. Endocrine treatment has no significant effect on the EGF-R in these tumor models.

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Authors and Affiliations

  1. Department of Urology and Andrology, University of Umeå, S-901 85, Umeå, Sweden

    J. -E. Damber

  2. Department of Pathology, University of Umeå, S-901 85, Umeå, Sweden

    A. Bergh

  3. Department of Physiology, University of Umeå, S-901 85, Umeå, Sweden

    B. Assarsson & M. Gåfvels

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  1. J. -E. Damber
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  2. A. Bergh
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  3. B. Assarsson
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  4. M. Gåfvels
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Damber, J.E., Bergh, A., Assarsson, B. et al. Epidermal growth factor receptor content in rat prostatic adenocarcinoma: effects of endocrine treatment. Urol Res 23, 119–125 (1995). https://doi.org/10.1007/BF00307942

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  • DOI: https://doi.org/10.1007/BF00307942

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