Abstract
This study determined whether the genotype of bone marrow-derived inflammatory cells contributes to the more pronounced leukocytic exudation and extensive new muscle formation seen in SJL/J compared with BALB/c mice after a crush-injury (Mitchell et al. 1992). Female SJL/J mice were whole-body irradiated and reconstituted with male bone marrow from the BALB/c strain, and irradiated BALB/c females reconstituted with male SJL/J bone marrow. The mice were allowed to recover for 3 weeks and the tibialis anterior muscle (in a leg which had been protected from irradiation) was injured by crushing. At 3 and 10 days after injury the extent of necrotic debris, mononuclear leukocytic infiltration and new muscle formation was assessed in the muscles. The SJL/J mice reconstituted with BALB/c bone marrow showed extensive mononuclear leukocytic infiltration and clearance of necrotic debris when compared with BALB/c mice reconstituted with SJL/J bone marrow, and these strain-specific differences mirrored those seen with control bone marrow reconstituted hosts and non-irradiated hosts. The results show that the genotype of the bone marrow-derived macrophages is not responsible for the superior regeneration of crush-injured skeletal muscle in SJL/J mice, and it appears that factors intrinsic to the muscle tissue may be of central importance.
Similar content being viewed by others
References
Bonney RJ, Gery I, Lin T-I, Meyenhofer MF, Acevedo W, Davies P (1978) Mononuclear phagocytes from carrageenan induced granulomas. J Exp Med 148:261–275
Bubbers LE (1983) Single gene abrogation of spontaneous pleomorphic SJL/J mouse reticulum cell sarcoma expression. J Natl Cancer Inst 71:795–799
Cläesson MH, Warner N, McKenzie IFC (1978) B-lymphocyte colony forming cells in the SJL/J mouse thymus graft repopulation: independence of host thymus and graft phenotype. Scand J Immunol 8:557–561
Crowle AJ, May M (1978) A hanging drop macrophage function test. J Reticuloendothel Soc 24:169–185
Goichot J, Joyeux Y (1977) Comparative study of macrophage function in different strains of mice: absence of migration in C3H mice. J Immunol Methods 257:261
Grounds MD (1983) Skeletal muscle precursors do not arise from bone marrow cells. Cell Tissue Res 234:713–722
Grounds MD, McGeachie JK (1989) A comparison of muscle precursor replication in crush-injured skeletal muscle of Swiss and Balb/c mice. Cell Tissue Res 255:385–391
Grounds MD, McGeachie JK (1990) Myogenic cell replication in minced skeletal muscle isografts of Swiss and BALB/c mice. Muscle Nerve 13:305–313
Grounds MD, Lai MC, Fan Y, Codling JC, Beilharz MW (1992) Transplantation in the mouse model: the use of a Y-chromosome specific DNA clone to identify donor cells in situ. Transplantation 52:1101–1105
Lotzova E, Dicke KA, Trentin JJ, Gallagher MT (1977) Genetic control of bone marrow transplantation in irradiated mice: classification of mouse strains according to their responsiveness to bone marrow allografts and xenografts. Transplantation Proc 9:289–292
Maley MAL, Fan Y, Beilharz MW, Grounds MD (1994) Intrinsic differences in MyoD and myogenin expression between primary cultures of SJL/J and BALB/c skeletal muscle. Exp Cell Res 222:99–107
Mastaglia FL, Dawkins RL, Papadimitriou JM (1975) Morphological changes in skeletal muscle after transplantation. J Neurol Sci 25:227–247
McGeachie JK, Grounds MD (1987) Initiation and duration of muscle precursor replication after mild and severe injury to skeletal muscle of mice: An autoradiographic study. Cell Tissue Res 248:125–130
Mitchell CA, McGeachie JK, Grounds MD (1992) Cellular differences in the regeneration of murine skeletal muscle: a quantitative histological study in SJL/J and BALB/c mice. Cell Tissue Res 269:159–166
Nishioka Y (1987) Y-chromosomal DNA polymorphism in mouse inbred strains. Genet Res Camb 50:69–72
Papadimitriou JM, Ashman RB (1989) Macrophages: Current views on their differentiation, structure and function. Ultrastr Pathol 13:343–372
Robertson TA, Grounds MD, Mitchell CA, Papadimitriou JM (1990) Fusion between myogenic cells in vivo: an ultrastructural study in regenerating murine skeletal muscle. J Struct Biol 105:170–182
Robertson TA, Grounds MD, Papadimitriou JM (1992) Elucidation of aspects of murine skeletal muscle regeneration using local and whole body irradiation. J Anat 181:265–276
Robertson TA, Maley MAL, Grounds MD, Papadimitriou JM (1993) The role of macrophages in skeletal muscle regeneration with particular reference to chemotaxis. Exp Cell Res 207:321–331
Roderick TH (1963) The response to twenty-seven inbred strains of mice to daily doses of whole body X-irradiation. Rad Res 20:631–639
Rosenberg NL (1993) Experimental models of inflammatory myopathies. In: Mastaglia F (ed) Inflammatory muscle disease. Baillieres, London
Staats J (1976) Standardized nomenclature for inbred strains of mice: sixth listing. Cancer Res 36:4333–4377
Teuscher C (1985) Experimental allergic orchitis in mice. Immunogenetics 22:417–425
Vriesendorp HM, Lowenberg B, Visser TP, Knaan S, Bekkum DW van (1976) Influence of genetic resistance and silica particles on survival after bone marrow transplantation. Transplantation Proc 8:483–489
Wiltrout RH, Brunda MJ, Gorelik E, Petersen EK, Dunn JJ, Leonhardt J, Varesio L, Reynolds CW, Holden HT (1983) Distributions of peritoneal macrophage populations after intravenous injection in mice: differential effects of eliciting and activating agents. J Reticuloendothel Soc 34:253–269
Yong T, Meininger GA, Linthicum DS (1993) Enhancement of histamine-induced vascular leakage by pertussis toxin in SJL/J mice but not in BALB/c mice. J Neuroimmunol 45:47–52
Yuhas J, Storer JB (1969) On mouse strain differences in radiation resistance: Hematopoietic death and the endogenous colonyforming unit. Rad Res 39:608–622
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mitchell, C.A., Grounds, M.D. & Papadimitriou, J.M. The genotype of bone marrow-derived inflammatory cells does not account for differences in skeletal muscle regeneration between SJL/J and BALB/c mice. Cell Tissue Res 280, 407–413 (1995). https://doi.org/10.1007/BF00307814
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00307814