Abstract
Sotalol [4-(2-isopropylamino-1-hydroxyethyl)-methane-sulfonanilide hydrochloride] is a beta-adrenergic blocking agent. Despite the widespread use of these drugs, poisonings are not frequent. In this report the authors describe the first recorded case of fatal sotalol overdosage to their knowledge. The results of toxicological analysis, performed by a specially developed method, are presented, and compared with findings in fatal intoxications with other beta-adrenergic blocking agents.
Zusammenfassung
Sotalol [4-(2-isopropylamino-1-hydroxyathyl)-methansulfonanilid-hydrochlorid] ist eine β-adrenolytische Substanz. Obwohl es sich um ein weitverbreitetes Mittel handelt, sind Vergiftungen nicht sehr häufig. In diesem Bericht beschreiben die Autoren den ersten von ihnen registrierten Fall einer Überdosis von Sotalol mit tödlichem Ausgang. Die Resultate der toxikologischen Analyse, ausgeführt mittels einer speziell von uns entwickelten Methode, werden verglichen mit Ergebnissen letaler Intoxikationen, hervorgerufen durch andere β-Adrenolytika.
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Montagna, M., Groppi, A. Fatal sotalol poisoning. Arch Toxicol 43, 221–226 (1980). https://doi.org/10.1007/BF00297587
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DOI: https://doi.org/10.1007/BF00297587