Summary
The core and coat of hepatitis B virus were found by electron microscopy in parenchymal cells of a liver biopsy from a 61 year old man with chronic active hepatitis and cirrhosis of the liver. Laparoscopy, 35 days after liver biopsy, and autopsy 42 days later confirmed the cirrhosis and showed in addition a well differentiated hepatoma. The possibility of a viral aetiology for the cirrhosis and primary carcinoma of the liver is considered.
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Reference
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Kendrey, G., László, B. Hepatitis B virus, cirrhosis and primary carcinoma of the liver. Z. Krebsforsch. 88, 97–100 (1976). https://doi.org/10.1007/BF00284749
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DOI: https://doi.org/10.1007/BF00284749