Summary
Chromosome studies were carried out on three patients for the following reasons: (1) growth retardation and mental subnormality in a boy; (2) marked developmental delay in a female infant; (3) routine check on a man whose wife had a stillborn with congenital anomalies.
An interstitial deletion at 7q11::7q21 was observed in all three cases.
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References
Higginson, G., Weaver, D. D., Magenis, R. E., Prescott, G. H., Haag, C., Hepburn, D. J.: Interstitial deletion of the long arm of chromosome No. 7 (7q-) in an infant with multipel congenital anomalies. Clin. Genet. 10, 307–312 (1976)
Paris Conference (1971): Standardization in human cytogenetics. Birth defects: Orig. Art. Ser. VIII/7. New York: The National Foundation 1972
Seabright, M.: A rapid banding technique for human chromosomes. Lancet 1971 II, 971–972
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Seabright, M., Lewis, G.M. Interstitial deletion of chromosome 7 detected in three unrelated patients. Hum Genet 42, 223–226 (1978). https://doi.org/10.1007/BF00283642
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DOI: https://doi.org/10.1007/BF00283642