Summary
The Philadelphia chromosome, assessed with banding techniques, was detected in 98.3% of bone marrow cells of a 46-year-old black female presenting with essential thrombocytosis. The patient has been followed for the past two years with no signs of chronic myelocytic leukemia. Her platelet counts remain elevated, and she shows no other hematologic changes. Comparisons with the 21q- marker associated with thrombocytosis are made. The role of the Ph' chromosome in myeloid malignant changes and the implications of the present findings in thrombocytosis are discussed.
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Rajendra, B.R., Lee, Ml., Nissenblatt, M.J. et al. The occurrence of the Philadelphia chromosome in essential thrombocytosis. Hum Genet 56, 287–291 (1981). https://doi.org/10.1007/BF00274681
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DOI: https://doi.org/10.1007/BF00274681