Summary
A new method of investigating the efficacy of regional thermotherapy in subcutaneous xenografts of nude mice is reported. The use of high frequency hyperthermia was well tolerated by the sensitive animals and allowed an exact continuous temperature measurement in different tumor regions. The interstitial procedure in this model could be the best approach for later clinical use in urology, e.g. for prostate treatment and is an alternativ to the transrectal hyperthermia application.
Similar content being viewed by others
References
Emami B, Perez CA, Leybovich L, Straube W, Vongerichten D (1987) Interstitial thermoradiotherapy in treatment of malignant tumors. Int J Hyperthermia 3:107–118
Giovanella BC, Stehlin JS, Shepard RC, Wiliams LJ (1979) Hyperthermic treatment of human tumors heterotransplanted in nude mice. Cancer Res 39:2236–2241
Hahn GM, Braun K, Har-Kedar I (1975) Thermochemotherapy: synergism between hyperthermia (42–43°) and Adriamycin (or Bleomycin) in mammalion cell inactivation. Proc Natl Acad Sci USA 72:937–940
Issels RD, Wadepohl M, Tiling K, Müller M, Sauer H, Wilmanns W (1988) Regional hyperthermia combined with systemic chemotherapy in advanced abdominal and pelvic tumors: first results of a pilot study employing an anular phased array applicator. Recent Results Cancer Res 107:236–243
Mechling JA, Strohbein JW (1986) A theoretical comparison of the temperature distributions produced by three interstitial hyperthermia systems. Int J Radiat Oncol Biol Phys 12:2137–2149
Song CW (1984) Effect of local hyperthermia on blood flow and microenvironment. Cancer Research [Suppl 4] 44:4721–4730
Yerushalmi A, Fishelovitz Y, Singer D, Reiner I, Arielly J, Abramovia Y, Catsenelson R, Levy E, Shami A (1985) Localized deep microwave hyperthermia in the treatment of poor operative risk patients with benign prostatic hyperplasia. J Urol 133:873–876
Author information
Authors and Affiliations
Additional information
This study was supported by the Stiftung Bauer
Rights and permissions
About this article
Cite this article
Fabricius, P.G., Schmitz, K., Wadepohl, M. et al. A new method of investigating the efficacy of regional thermotherapy in subcutaneous xenografts of nude mice. Urol. Res. 17, 219–221 (1989). https://doi.org/10.1007/BF00262596
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00262596