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Use of sodium bicarbonate as a means of ameliorating doxorubicin-induced dermal necrosis in rats

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Summary

To test whether NaHCO3 infiltration provides protection against doxorubicin-induced dermal necrosis, we infiltrated rat dermis with doxorubicin immediately followed by NaHCO3 (experimental) or saline (control) and measured the subsequent evolution of necrosis, erythema, and induration. Experimental groups were substantially protected, having a reduction of the maximum area of the lesion and more rapid healing.

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Authors and Affiliations

  1. Division of Medical Oncology, Oncology Day Care Center, Stanford University School of Medicine, Room C005, 94305, Stanford, California, USA

    Linda Bartkowski-Dodds & J. R. Daniels

Authors
  1. Linda Bartkowski-Dodds
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  2. J. R. Daniels
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Bartkowski-Dodds, L., Daniels, J.R. Use of sodium bicarbonate as a means of ameliorating doxorubicin-induced dermal necrosis in rats. Cancer Chemother. Pharmacol. 4, 179–181 (1980). https://doi.org/10.1007/BF00254015

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  • DOI: https://doi.org/10.1007/BF00254015

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