Abstract
57Co-bleomycin and 99mTc-sulfur colloid scans were performed in 13 southern African black patients with primary hepatocellular cancer (PHC) and 3 patients with other space-occupying hepatic lesions. Selective concentration of 57Co-bleomycin in the defect or defects seen on the 99mTc-sulfur colloid scan occurred in only 4 of the 13 (31%) patients with PHC. In the remaining PHC patients, as well as in the 2 patients with metastatic liver disease and the 1 patient with an amebic liver abscess, the 57Co-bleomycin and 99mTc-sulfur colloid scans were identical. 57Co-bleomycin appears to have only a limited place as a tumor-seeking agent in the diagnosis of PHC in southern African blacks.
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References
Berman, C.: In: Primary carcinoma of the liver, pp. 5–18. London: H.K. Lewis 1951
Eckelman, W.C., Rzeszotarski, W.J., Siegel, B.A., Kubota, H., Chelliah, M., Stevenson, J., Reba, R.C.: Chemical and biologic properties of isolated radiolabelled bleomycin preparations. J. nucl. Med. 16, 1033 (1975)
Grove, R.B., Reba, R.C., Eckelman, W.C., Goodyear, M.: Clinical evaluation of radiolabelled bleomycin for tumor detection. J. nucl. Med. 15, 386 (1974)
Higginson, J., Oettle, A.: Cancer incidence in Bantu and Cape coloured races of South Africa. Report of a cancer survey in Transvaal 1953–1955. J. nat. Cancer. Inst. 24, 589 (1960)
Hisada, K., Ando, A., Suzuki, Y.: Comparison between 57Co-bleomycin, 99mTc-bleomycin and 111In-bleomycin as tumor scanning agents. Radioisotopes 23, 37 (1974)
Kew, M.C., Geddes, E.W., Levin, J.: False-negative 75Se-selenomethionine scans in primary liver cancer. J. nucl. Med. 15, 234 (1974)
Levin, J., Kew, M.C.: Gallium67 citrate scanning in primary liver cancer: Diagnostic value in the presence of cirrhosis and relation to alpha-fetoprotein. J. nucl. Med. 16, 949 (1975)
Maeda, T., Tanaka, M.: Uptake of 57Co-bleomycin by liver tumor. Radioisotopes 22, 310 (1973)
Poulouse, K.P., Watkins, A.E., Reba, R.C., Eckelman, W.C., Goodyear, M.: Cobalt-labelled bleomycin, a new radiopharmaceutical for tumor localisation. A comparative clinical evaluation with gallium citrate. J. nucl. Med. 16, 839 (1975)
Rasker, J.J., van de Poll, M.A.P.C., Beekhuis, H., Woldring, W.G., Hieweg, H.O.: Some experience with 57Co-bleomycin as a tumor seeking agent. J. nucl. Med. 16, 1058 (1975)
Suzuki, Y., Hisada, K., Hiraki, T.: Clinical evaluation of tumor scanning with 57Co-bleomycin. Radiology 113, 139 (1974)
Suzuki, H., Nagai, K., Akutsu, E.: On the mechanism of action of bleomycin. Strand scission of DNA caused by bleomycin and its binding to DNA in vitro. J. Antibiot. 23, 473 (1970)
Thakur, M.L., Merrick, M.V., Gunasekera, S.W.: Some pharmacological aspects of a new radiopharmaceutical, Indium-111 bleomycin. In: Developments in radiopharmaceuticals and labelled compounds. Vienna: IAEA (to be published)
van Dyk, J.J., Falkson, G.: Unpublished data (1975)
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Kew, M., Allen, J. & Levin, J. 57-Cobalt-bleomycin as a tumor scanning agent in primary hepatocellular cancer. Eur J Nucl Med 1, 247–250 (1976). https://doi.org/10.1007/BF00252171
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DOI: https://doi.org/10.1007/BF00252171