Abstract
Sprague-Dawley rats were treated with varying quantities of parathyroid hormone for 1–3 days, then sacrificed at periods ranging from 1–6h after administration of 99mTc-pyrophosphate. Very little increase in bone accumulation of tracer occurred with this treatment. A small, but obvious decrease occurred in the blood levels of 99mTc-pyrophosphate and a smaller and less consistent decrease was affected in the muscle levels of the radiopharmaceutical. The overall result was an improvement in the bone/blood and bone/muscle ratios. It is suggested that the basis of the “supernormal” bone scan of hyperparathyroidism is achieved by this mechanism and that the increased bone uptake of other ions in response to parathyroid hormone is not shared by 99mTc-pyrophosphate.
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References
Costeas A, Woodard HQ, Laughlin JS (1971) Comparative kinetics of calcium and fluoride in rabbit bone. Radiat Res 46:317–333
Dymling JF (1964) Calcium kinetics in osteopenia and parathyroid disease. Acta Med Scand (Suppl 408) 175:6–6
Evans RG, Ashburn W, Batter FC (1969) Strontium85 scanning of a “brown tumor” in a patient with parathyroid carcinoma. Br J Radiol 42:224–225
Fraser R, Harrison M, Ibbertson K (1960) The rate of calcium turnover in bone. Q J Med 29:85–111
Kaye M, Silverton S, Rosenthall L (1975) Technetium-99m-pyrophosphate: Studies in vivo and in vitro. J Nucl Med 16:40–45
Krishnamurthy GT, Brickman AS, Blahd WH (1977) Technetium-99m-Sn-pyrophosphate pharmacokinetics and bone image changes in parathyroid disease. J Nucl Med 18:236–242
Krishnamurthy GT, Thomas PB, Tubis M (1974) Comparison of 99mTc-polyphosphate and 18F. I. Kinetics. J Nucl Med 15:832–836
Krishnamurthy GT, Walsh CF, Shoop LE (1974) Comparison of 99mTc-polyphosphate and 18F. II. Imaging. J Nucl Med 15:837–841
Rich C (1957) The calcium metabolism of a patient with renal insufficiency before and after partial parathyroidectomy. Met 6:574–582
Rosenthall L, Kaye M (1975) Technetium-99m-pyrophosphate kinetics and imaging in metabolic bone disease. J Nucl Med 16:33–39
Sy W (1974) Bone scan in primary hyperparathyroidism. J Nucl Med 15:1089–1091
Wiegmann T, Rosenthall L, Kaye M (1977) Technetium-99m-pyrophosphate bone scans in hyperparathyroidism. J Nucl Med 18:231–235
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Halpern, S.E., Hagan, P.L., Chauncey, D.M. et al. The effect of parathyroid hormone on technetium-99m pyrophosphate distribution in rats. Eur J Nucl Med 5, 515–519 (1980). https://doi.org/10.1007/BF00252042
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DOI: https://doi.org/10.1007/BF00252042