Abstract
Regional cerebral turnover of 11C following intravenous injection of 11C-1-pyruvate was investigated in 12 patients with brain tumors. The positron emission tomography (PET) image taken at 10–15 min after the injection always demonstrated a high concentration of 11C in tumor, and thus visualized precise tumor contours. This phenomenon was not influenced qualitatively by the variation of blood flow in the tumor. Brain edema associated with the tumor was not visualized. We conclude that the localization of brain tumors would be well determined by the PET scan, using 11C-1-pyruvate.
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References
Aisenberg AC (1961) The glycolysis and respiration of tumors. Academic Press, New York
Bradley Jr WG, Waluch V, Yadley RA, Wycoff RR (1984) Comparison of CT and MR in 400 patients with suspected disease of the brain and cervical spinal cord. Radiology 152:695–702
Busch H (1955) Studies on the metabolism of pyruvate-2-C14 in tumor-bearing rats. Cancer Res 15:365–374
Bydder GM, Steiner RE, Thomas DJ, Marshall J, Gilderdale DJ, Young IR (1983) Nuclear magnetic resonance imaging of the posterior fossa: 50 cases. Clin Radiol 34:173–188
Damadian R (1971) Tumor detection by nuclear magnetic resonance. Science 171:1151–1153
Di Chiro G, DeLaPaz RL, Brooks RA, Sokoloff L, Kornblith PL, Smith BH, Patronas NJ, Kufta CV, Kessler RM, Johnston GS, Manning RG, Wolf AP (1982) Glucose utilization of cerebral gliomas measured by [18F]fluorodeoxyglucose and positron emission tomography. Neurology 32:1323–1329
Ericson K, Lilja A, Bergström M, Collins VP, Eriksson L, Ehrin E, von Holst H, Lundqvist H, Långström B, Mosskin M (1985) Positron emission tomography with ([11C]methyl)-l-methionine, [11C]D-glucose and [68Ga]EDTA in supratentorial tumors. J Comput Assist Tomogr 9:683–689
Frackowiak RSJ, Lenzi GL, Jones T, Heather JD (1980) Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man, using 15O and positron emission tomography: theory, procedure and normal values. J Comput Assist Tomogr 4:727–736
Hans JS, Huss RG, Benson JE, Kaufman B, Yoon YS, Morrison SC, Alfidi RJ, Rekate HL, Ratcheson RA (1984) MR imaging of the skull base. J Comput Assist Tomogr 8:944–952
Hara T, Yokoi F (1986) Difference of 14C turnovers in brain and in transplanted glioma after intravenous injection of 14C-1-pyruvate into rats. Eur J Nucl Med (in press)
Hara T, Iio M, Izuchi R, Tsukiyama T, Yokoi F (1985) Synthesis of pyruvate-1-11C as a radiopharmaceutical for tumor imaging. Eur J Nucl Med 11:275–278
Hawkes RC, Holland GN, Moore WS, Worthington BS (1980) Nuclear magnetic resonance (NMR) tomography of the brain: a preliminary clinical assessment with demonstration of pathology. J Comput Assist Tomogr 4:577–586
Hübner KF, Purvis JT, Mahaley Jr SM, Robertson JT, Rogers S, Gibbs W, King P, Partain CL (1982) Brain tumor imaging by positron emission computed tomography using 11C-labeled amino acids. J Comput Assist Tomogr 6:544–550
Ito M, Lammertsma AA, Wise RJS, Bernardi S, Frackowiak RSJ, Heather JD, McKenzie CG, Thomas DGT, Jones T (1982) Measurements of regional cerebral blood flow and oxygen utilization in patients with cerebral tumors using 15O and positron emission tomography: analytical techniques and preliminary results. Neuroradiology 23:63–74
Jähde E, Rajewsky MF (1982) Tumor selective modification of cellular microenvironment in vivo: effect of glucose infusion on the pH in normal and malignant rat tissues. Cancer Res 42:1505–1512
Jähde E, Rajewsky MF, Baumgärtl H (1982) pH distributions in transplanted neural tumors and normal tissues of BDIX rats as measured with pH microelectrodes. Cancer Res 42:1498–1504
Kalcker HM (1976) Cellular regulation of transport and uptake of nutrients: an overview. J Cell Physiol 89:503–516
Lowry OH, Berger SJ, Carter JG, Chi MMY, Manchester JK, Knor J, Pusateri ME (1983) Diversity of metabolic patterns in human brain tumors: enzymes of energy metabolism and related metabolites and cofactors. J Neurochem 41:994–1010
Moolten FL, Moolten DN, Capparell NJ (1977) Transformed BHK cells exhibiting normal or subnormal sugar uptake. J Cell Physiol 93:147–152
Odendorf WH (1973) Carrier-mediated blood-brain barrier transport of short-chain monocarboxylic organic acids. Am J Physiol 224:1450–1453
Pouysségur J, Franchi A, Salomon JC, Silvestre P (1980) Isolation of a Chinese hamster fibroblast mutant defective in hexose transport and aerobic glycolysis: its use to dissect the malignant phenotype. Proc Natl Acad Sci USA 77:2698–2701
Ross A, Boron WF (1981) Intracellular pH. Physiol Rev 61:296–434
Shishido F, Tateno Y, Yamasaki T, Irie T, Inoue O, Tamate K, Suzuki K, Nakayama T, Takashima T, Yamamura A, Kurisu A, Ikehira H (1982) Positron CT imaging with with 13N-ammonia and 11C-carbonmonoxide in intracranial tumors. Jpn J Nucl Med 19:1035–1038
Spencer TL, Lehninger AL (1976) l-Lactate transport in Ehrlich ascites-tumor cells. Biochem J 154:405–414
Thomas RC (1976) The effect of carbon dioxide on the intracellular pH and buffering power of animal neurons. J Physiol 255:715–735
Warburg O (1926) Über den Stoffwechsel der Tumoren. Springer, Berlin
Warburg O (1956) On the origin of cancer cells. Science 123:309–314
Yamamoto YL, Thompson CJ, Meyer E, Robertson JS, Feindel W (1977) Dynamic positron emission tomography for study of cerebral hemodynamics in a cross section of the head using positron-emitting 68Ga-EDTA and 77Kr. J Comput Assist Tomogr 1:43–56
Young IR, Bailes DR, Burl M, Collins AG, Smith DT, McDonnell MJ, Orr JS, Banks LM, Bydder GM, Greenspan RH, Steiner RE (1982) Initial clinical evaluation of a whole body nuclear magnetic resonance (NMR) tomography. J Comput Assist Tomogr 6:1–18
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Tsukiyama, T., Hara, T., Iio, M. et al. Preferential accumulation of 11C in human brain tumors after intravenous injection of 11C-1-pyruvate. Eur J Nucl Med 12, 244–248 (1986). https://doi.org/10.1007/BF00251978
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DOI: https://doi.org/10.1007/BF00251978