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Organization of the thalamo-cortical connexions to the frontal lobe in the rhesus monkey

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Summary

In 25 rhesus monkeys horseradish peroxidase was injected in different parts of the frontal cortex. The retrogradely labelled thalamic neurons formed longitudinal bands, some of which crossed the internal medullary lamina, and extended from one thalamic nucleus into another. On the basis of these findings the frontal cortex was subdivided into seven transverse cortical strips which receive afferents from seven longitudinal bands of thalamic neurons. The most rostral transverse strip receives afferents from the most medial thalamic band which is oriented vertically and extends through the most medial part of the MD into the medial pulvinar. Progressively more caudally located transverse strips receive afferents from progressively more laterally located thalamic bands which in part are situated in the VL and show an increasing tilt towards the horizontal. Moreover, those parts of the various bands which are situated along the dorsal and lateral margin of the thalamus project to the medial portions of the transverse cortical strips, i.e. along the medial margin of the frontal lobe, while the other parts situated ventromedially in the thalamus project to the lateral portions of these strips, i.e. along the lateral margin of the frontal lobe.

These data provide an alternative view of the organization of the thalamus and suggest that this structure contains a matrix of longitudinal cell columns which in some cases extend across specific nuclear borders and may represent the basic thalamic building blocks in respect to the thalamo-cortical connexions.

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References

  • Akert, K.: Comparative anatomy of frontal cortex and thalamofrontal connections. In: The Frontal Granular Cortex and Behaviour (eds. J.M. Warren and K. Akert). New York: McGraw-Hill 1964

    Google Scholar 

  • Astruc, J.: Corticofugal connections of area 8 (frontal eye field) in Macaca mulatta. Brain Res. 33, 241–256 (1971)

    Google Scholar 

  • Bonin, G. von, Bailey, P.: The Neocortex of Macaca Mulatta, pp. 136. Urbana, Ill.: University of Illinois Press 1947

    Google Scholar 

  • Bos, J., Benevento, L.A.: Projections of the medial pulvinar to orbital cortex and frontal eye fields in rhesus monkey (Macaca mulatta). Exp. Neurol. 49, 487–496 (1975)

    Google Scholar 

  • Bowsher, D.: Some afferent and efferent connections of the parafascicular-center median complex. In: The Thalamus (eds. D.P. Purpura and M.D. Yahr), pp. 99–108. New York: Columbia University Press 1966

    Google Scholar 

  • Brodal, A.: Modification of Gudden method for study of cerebral localization. Arch. Neurol. Psychiat. Chicago 43, 46–58 (1940)

    Google Scholar 

  • Bunt, A.H., Hendrickson, A.E., Lund, J.S., Lund, R.D., Fuchs, A.F.: Monkey retinal ganglion cells: Morphometric analysis and tracing of axonal projection, with a consideration of peroxidase technique. J. comp. Neurol. 164, 265–286 (1975)

    Google Scholar 

  • Bunt, A.H., Lund, R.D., Lund, J.S.: Retrograde axonal transport of horseradish peroxidase by banglion cells of albino rat retina. Brain Res. 73, 215–228 (1974)

    Google Scholar 

  • Burton, H., Jones, E.G.: The posterior thalamic region and its cortical projection in new world and old world monkeys. J. comp. Neurol. 168, 249–302 (1976)

    Google Scholar 

  • Carmel, P.W.: Efferent projections of the ventral anterior nucleus of the thalamus in the monkey. Amer. J. Anat. 128, 159–184 (1972)

    Google Scholar 

  • Chow, K.L.: A retrograde cell degeneration study of the cortical projection field of the pulvinar in the monkey. J. comp. Neurol. 93, 315–340 (1950)

    Google Scholar 

  • Chow, K.L., Pribram, K.H.: Cortical projection of the thalamic ventrolateral nuclear group in monkeys. J. comp. Neurol. 104, 57–75 (1956)

    Google Scholar 

  • Clark, W.E. Le Gros, Boggon, R.H.: The thalamic connexions of the parietal and frontal lobes of the brain in the monkey. Phil. Trans. B 224, 313–359 (1935)

    Google Scholar 

  • Crouch, R.L.: The nuclear configuration of the thalamus of Macacus rhesus. J. comp. Neurol. 59, 451–485 (1934)

    Google Scholar 

  • Dekker, J.J., Kievit, J., Jacobson, S., Kuypers, H.G.J.M.: Retrograde axonal transport of horseradish peroxidase in the forebrain of the rat, cat and rhesus monkey. In: Prospectives in Neurobiology. Golgi Centennial Symposium (ed. M. Santini), pp. 201–208. New York: Raven Press 1975

    Google Scholar 

  • DeVito, J.L.: Projections from the cerebral cortex to intralaminar nuclei in monkey. J. comp. Neurol. 136, 193–202 (1969)

    Google Scholar 

  • DeVito, J.L., Simmons, D.M.: Some connections of the posterior thalamus in monkey. Exp. Neurol. 51, 347–362 (1976)

    Google Scholar 

  • DeVito, J.L., Smith, O.A. Jr.: Subcortical projections of the prefrontal lobe of the monkey. J. comp. Neurol. 123, 413–424 (1964)

    Google Scholar 

  • Freeman, W., Watts, J.W.: Retrograde degeneration of the thalamus following prefrontal lobotomy. J. comp. Neurol. 86, 65–93 (1947)

    Google Scholar 

  • Graham, R.C., Karnovsky, M.J.: The early stages of absorption of injected horseradish peroxidase in the proximal tubules of the mouse kidney: Ultrastructural cytochemistry by a new technique. J. Histochem. Cytochem. 14, 291–302 (1966)

    Google Scholar 

  • Jones, E.G.: Possible determinants of the degree of retrograde neuronal labelling with horseradish peroxidase. Brain Res. 85, 249–253 (1975)

    Google Scholar 

  • Jones, E.G., Leavitt, R.Y.: Retrograde axonal transport and the demonstration of non-specific projections to the cerebral cortex and striatum from thalamic intralaminar nuclei in the rat, cat and monkey. J. comp. Neurol. 154, 349–378 (1974)

    Google Scholar 

  • Jones, E.G., Powell, T.P.S.: Connexions of the somatic sensory cortex of the rhesus monkey. III. Thalamic connexions. Brain 93, 37–56 (1970)

    Google Scholar 

  • Kievit, J., Kuypers, H.G.J.M.: Fastigial cerebellar projections to the ventrolateral nucleus of the thalamus and the organization of the descending pathways. In: Corticothalamic Projections and Sensorimotor Activities (eds. T. Frigyesi, E. Rinvik and M.D. Yahr), pp. 91–114. New York: Raven Press 1972

    Google Scholar 

  • Kristensson, K., Olsson, Y.: Retrograde axonal transport of protein. Brain Res. 29, 363–365 (1971)

    Google Scholar 

  • Kristensson, K., Olsson, Y.: Retrograde transport of horseradish peroxidase in transected axons. Time relationships between transport and induction of chromatolysis. Brain Res. 79, 101–109 (1974)

    Google Scholar 

  • Kruger, L., Porter, P.: A behavioural study of the functions of the Rolandic cortex in the monkey. J. comp. Neurol. 109, 439–478 (1958)

    Google Scholar 

  • Künzle, H.: Thalamic projections from the precentral motor cortex in Macaca fascicularis. Brain Res. 105, 253–267 (1976)

    Google Scholar 

  • Kuypers, H.G.J.M.: Centremedian. Comments on W. R. Mehler, Centremedian nucleus of Luys. In: The Thalamus (eds. D.P. Purpura and M.D. Yahr), pp. 109–127. New York: Columbia University Press 1966

    Google Scholar 

  • Kuypers, H.G.J.M., Kievit, J., Groen-Klevant, A.C.: Retrograde axonal transport of horseradish peroxidase in rat's forebrain. Brain Res. 67, 211–218 (1974)

    Google Scholar 

  • Kuypers, H.G.J.M., Lawrence, D.G.: Cortical projections to the red nucleus and the brain stem in the rhesus monkey. Brain Res. 4, 151–188 (1967)

    Google Scholar 

  • Kuypers, H.G.J.M., Maisky, V.A.: Retrograde axonal transport of horseradish peroxidase from spinal cord to brain stem cell groups in the cat. Neurosc. Lett. 1, 9–14 (1975)

    Google Scholar 

  • LaVail, J.H., LaVail, M. M.: Retrograde axonal transport in the central nervous system. Science 176, 1416–1417 (1972)

    Google Scholar 

  • Macchi, G., Quattrini, A., Chinzari, P., Capocchi, G.: Valutazione quantitativa della perdite cellulari nei nuclei intralaminari del talamo dopo lesioni corticali et sottocorticali. Boll. Soc. ital. Biol. sper. 46, 218–221 (1970)

    Google Scholar 

  • Mehler, W.R.: Further notes on the center median nucleus of Luys. In: The Thalamus (eds. D.P. Purpura and M.D. Yahr), pp. 109–122. New York: Columbia University Press 1966

    Google Scholar 

  • Meyer, A., Beck, E., McLardy, T.: Prefrontal leucotomy: A neuroanatomical report. Brain 70, 18–49 (1947)

    Google Scholar 

  • Mizuno, N., Konishi, A., Sato, M., Kawaguchi, S., Yamamoto, T., Kawamura, S., Yamawaki, M.: Thalamic afferents to the rostral portions of the middle suprasylvian gyrus in the cat. Exp. Neurol. 48, 79–87 (1975)

    Google Scholar 

  • Murray, M.: Degeneration of some intralaminar thalamic nuclei after cortical removals in the cat. J. comp. Neurol. 127, 341–368 (1966)

    Google Scholar 

  • Nauta, W.J.H.: Neural associations of the amygdaloid complex in the monkey. Brain 85, 505–520 (1962)

    Google Scholar 

  • Olszewski, J.: The Thalamus of the Macaca Mulatta, an Atlas for Use with the Stereotaxic Instrument. Basel, New York: S. Karger 1952

    Google Scholar 

  • Petras, J.M.: Some fiber connections of the precentral cortex (areas 4 and 6) with the diencephalon in the monkey (Macaca mulatta). Anat. Rec. 148, 322 (1964)

    Google Scholar 

  • Petras, J.M.: Some efferent connections of the motor and somatosensory cortex of simian primates and felid, canid and procyonid carnivores. Ann. N. Y. Acad. Sci. 167, 469–505 (1969)

    Google Scholar 

  • Powell, T.P.S.: Residual neurons in the human thalamus following hemidecortication. Brain 75, 571–583 (1952)

    Google Scholar 

  • Powell, T.P.S., Mountcastle, V.B.: The cytoarchitecture of the postcentral gyrus of the monkey Macaca mulatta. Johns Hopk. Hosp. Bull. 105, 108–131 (1959)

    Google Scholar 

  • Roberts, T.S., Akert, K.: Insular and opercular cortex and its thalamic projections in Macaca mulatta. Schweiz. Arch. Neurol. Psychiat. 92, 1–43 (1963)

    Google Scholar 

  • Rose, J.E., Woolsey, C.N.: Cortical connections and functional organization of the thalamic auditory system of the cat. In: Biological and Biochemical Bases of Behaviour (eds. H.F. Harlow and C.N. Woolsey), pp. 127–150. Madison, Wisc.: University of Wisconsin Press 1958

    Google Scholar 

  • Sakai, S.: Some observations on the corticothalamic fiber connections in the monkey. Proc. Jap. Acad. 43, 822–826 (1967)

    Google Scholar 

  • Scheibel, M.E., Scheibel, A.B.: The organization of the ventral anterior nucleus of the thalamus. A Golgi study. Brain Res. 1, 250–268 (1966)

    Google Scholar 

  • Scheibel, M.E., Scheibel, A.B.: Structural organization of nonspecific thalamic nuclei and their projection toward cortex. Brain Res. 6, 60–94 (1967)

    Google Scholar 

  • Showers, M.J.C.: Correlation of the medial thalamic nuclear activity with cortical and subcortical neuronal arcs. J. comp. Neurol. 109, 261–315 (1958)

    Google Scholar 

  • Strick, P.L.: Anatomical analysis of ventrolateral thalamic input to primate motor cortex. J. Neurophysiol. 39, 1020–1031 (1976)

    Google Scholar 

  • Tanaka, D.: Effects of selective prefrontal decortication on escape behaviour in the monkey. Brain Res. 53, 161–173 (1973)

    Google Scholar 

  • Tanaka, D. Jr.: Thalamic projections of the dorsomedial prefrontal cortex in the rhesus monkey (Macaca mulatta). Brain Res. 110, 21–38 (1976)

    Google Scholar 

  • Tobias, T.J.: Afferents to prefrontal cortex from the thalamic mediodorsal nucleus in the rhesus monkey. Brain Res. 83, 191–212 (1975)

    Google Scholar 

  • Trojanowski, J.Q., Jacobson, S.: Medial pulvinar afferents to frontal eye fields in rhesus monkey demonstrated by horseradish peroxidase. Brain Res. 80, 395–411 (1974)

    Google Scholar 

  • Walker, A.E.: The Primate Thalamus. Chicago, Ill.: University of Chicago Press 1938a

    Google Scholar 

  • Walker, A. E.: The thalamus of the chimpanzee. IV. Thalamic projections to the cerebral cortex. J. Anat. (Lond.) 73, 37–93 (1938b)

    Google Scholar 

  • Woolsey, C.N., Settlage, P.H., Meyer, D.R., Spencer, W., Hamuy, P., Travis, A.M.: Patterns of localization in the precentral and “supplementary” motor areas and their relation to the concept of a premotor area. Res. Publ. Ass. nerv. ment. Dis. 30, 238–264 (1950)

    Google Scholar 

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  1. Department of Anatomy, Erasmus University Rotterdam Medical School, Rotterdam, The Netherlands

    J. Kievit & H. G. J. M. Kuypers

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  1. J. Kievit
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  2. H. G. J. M. Kuypers
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Kievit, J., Kuypers, H.G.J.M. Organization of the thalamo-cortical connexions to the frontal lobe in the rhesus monkey. Exp Brain Res 29, 299–322 (1977). https://doi.org/10.1007/BF00236173

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