Summary
In New Hampshire chickens, the primary clinical symptom of dystrophy is limitation of wing motility. Examination of the brachial-level motor unit in chick embryos homozygous for dystrophy reveals abnormalities in both muscular and neural components. Wing motility in these embryos is abnormal as early as six days, and there is a corresponding lack of differentiation of the pectoralis major muscle. The findings suggest that delayed development of brachial-level neuronal pathways is responsible for the decreased wing motility and early degeneration of the pectoral muscle.
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References
Allen ER (1978) Development of vertebrate skeletal muscle. Am Zool 18:101–111
Allen ER, Murphy BJ (1978) Sarcotubular development in dystrophic skeletal muscle cells. Cell Tiss Res 194:125–130
Allen ER, May JF (1979) Aspects of normal and dystrophic chicken muscle grown in vitro. Virchows Archiv Cell Pathol 31:243–250
Allen ER, Murphy BJ (1979) Early detection of inherited muscular dystrophy in chickens. Cell Tiss Res 197:165–167
Asmundson VS, Julian LM (1956) Inherited muscle abnormality in the domestic fowl. J Hered 47:248–252
Asmundson VS, Kratzer FH, Julian LM (1966) Inherited myopathy in the chicken. Ann NY Acad Sci 138:49–58
Cullen MJ, Fulthorpe JJ (1975) Stages in fibre breakdown in Duchenne microscopic study. J Neuro Sci 24:179–200
Guth L (1968) “Trophic” influences of nerve on muscle. Physiol Rev 48:645–648
Hadlow WJ (1973) Myopathies of animals. In: Pearson CF, Mostofi FK (eds) The striated muscle. Williams and Wilkins Co, Baltimore Maryland, pp 364–404
Hamburger V (1968) Emergence of nervous coordination. Origin of integrated behavior. Dev Biol Suppl 2:251–271
Hamburger V, Oppenheim R (1967) Prehatching behavior in the chick. J Exp Zool 166:171–204
Hamburger V, Balaban M, Oppenheim R, Wenger E (1965) Periodic motility of normal and spinal chick embryos between 8 and 17 days of incubation. J Exp Zool 159:1–14
Hamburger V, Wenger E, Oppenheim R (1966) Motility in the chick embryo in the absence of sensory input. J Exp Zool 162:133–160
Julian L (1973) Animal Model: Hereditary muscular dystrophy of the chicken. Am J Pathol 70:273–276
Linkhart TA, Yee GW, Nieberg PS, Wilson BW (1976) Myogenic defect in muscular dystrophy of the chicken. Dev Biol 48:447–457
Malouf N, Sommer J (1976) Chicken dystrophy: the geometry of the transverse tubule. Am J Pathol 84:299–316
Narayanan CH (1970) Apparatus and current techniques in the preparation of avian embryos for microsurgery and for observing embryonic behavior. Bioscience 20:869–870
Narayanan CH, Hamburger V (1971) Motility in chick embryos with substitution of lumbosacral by brachial spinal cord segments. J Exp Zool 178:415–432
Narayanan CH, Malloy RB (1974) Deafferentiation studies on motor activity in the chick II. Activity pattern of wings. J Exp Zool 189:177–188
Oppenheim RW (1973) Pre-hatching and hatching behavior: A comparative and physiological consideration. In: Gottlieb G (ed) Behavior Embryology, Academic Press, New York, pp 163–241
Oppenheim RW, Chu-Wang I, Foelix RF (1975) Some aspects of synaptogenesis in the spinal cord of the chick embryo: A quantitative electron microscopic study. J Comp Neurol 161:383–418
Platzer AC, Powell JA (1975) Fine structure of prenatal and early postnatal dystrophic mouse muscle. J Neurol Sci 24:109–126
Provine RR (1971) Embryonic spinal cord: Synchronizing and spacial distribution of polyneuronal burst discharges. Brain Res 29:155–158
Provine RR (1972) Ontogeny of bioelectric activity in the spinal cord of the chick embryo and its behavioral implication. Brain Res 41:365–378
Provine RR (1973) Neurophysiological aspects of behavior development in the chick embryo. In: Gottlieb G (ed) Behavior Embryology. Academic Press, New York, pp 77–102
Rathbone M, Stewart P, Vetrano F (1975) Dystrophic spinal cord transplants induce abnormal thymidine kinase activity in normal muscles. Science 189:1106–1107
Reynolds E (1963) The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol 17:208–213
Ripley KL, Provine RR (1972) Neural correlates of embryonic motility in the chick. Brain Res 45:127–134
Singer HS, Skoff RP, Price DL (1978) The development of intersegmental connections in embryonic spinal cord: An anatomic substrate for early embryonic motility. Brain Res 141:197–209
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Supported in part from institutional funds from the College of Osteopathic Medicine and Surgery and the National Osteopathic Foundation
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Murphy, B.J., Allen, E.R. & Narayanan, C.H. An analysis of the integrity of the brachial motor unit in the dystrophic chick embryo. Cell Tissue Res. 215, 537–545 (1981). https://doi.org/10.1007/BF00233530
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DOI: https://doi.org/10.1007/BF00233530