Abstract
During sexual behavior in the male rat, peptidergic cells in the medial amygdaloid nucleus become active and release a vasopressin-like peptide. The present experiments were designed to examine hippocampal changes as a result of this peptide's action during sexual behaviors. Chronic field-potential recordings from the hippocampus of male rats were acquired in a wide variety of social and nonsocial circumstances. Hippocampal responses that resemble the known action of the vasopressin-like peptide were seen only with social stimuli such as sexual stimuli and stimuli that led to aggressive behavior between males. The results show that the occasions of peptide action in the hippocampus correlate with the occasions of peptide release as determined by recording from the peptidergic cell bodies. The results are interpreted to indicate that the amygdala projection to the hippocampus has a special role to play in social behavior.
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References
Albeck D, Smock T (1988) A mechanism for vasopressin action in the hippocampus. Brain Res 463:394–397
Albeck D, Smock T, McMechen P, Purves D, Floyd L (1990) Peptidergic transmission in the brain. I. Vasopressin-like signal in the hippocampus. Brain Res 511:7–14
Albeck D, Bullock N, Marrs K, Cooper R, Smock T, DeVries G (1993) Antidromic activation of a peptidergic pathway in the limbic system. Brain Res 606:171–174
Argiolas A, Collu M, Gessa G, Melis M, Serra G (1988) The oxytocin antagonist d(CH3)3 tyr (ME)-orn8-vasotocin inhibits male copulatory performance in rats. Eur J Pharmacol 149:389–392
Baum MJ, Everitt BJ (1992) Increased expression of c-fos in the medial preoptic area after mating in male rats: role of afferent inputs from medial amygdala and midbrain central tegmental field. Neuroscience 50:627–646
Lehman MN, Winans SS, Powers JB (1980) Medial nucleus of the amygdala mediates chemosensory control of male hamster sexual behavior. Science 210:557–560
Minerbo G, Albeck D, Goldberg E, Lindberg T, Nakari M, Martinez C, Garritano J, Smock T (1994) Activity of peptidergic neurons in the amygdala during sexual behavior in the male rat. Exp Brain Res 97:444–450
Paxinos G, Watson C (1982) The rat brain in stereotaxic coordinates. Academic, Sydney
Smock T, Albeck D, McMechen, P (1990) Peptidergic transmission in the brain. II. Mediation by a vasopressin-like peptide. Brain Res 511:15–20
Smock T, Albeck D, McMechen P (1991), Peptidergic transmission in the brain. III. Mechanism of hippocampal inhibition by the amygdala. Peptides 12:47–51
Smock T, Arnold S, Albeck D, Emerson P, Garritano J, Burrows K, Derber W, Sanson C, Marrs K, Weatherly H, Kruse K (1992) A peptidergic circuit for reproductive behavior. Brain Res 598:138–142
Winslow JT, Hastings N, Carter CS, Harbaugh CR, Insel TR (1993) A role for central vasopressin in pair-bonding in monogamous prairie voles. Nature 365:545–548
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Garritano, J., Martinez, C., Grossman, K. et al. The output of the hippocampus is inhibited during social behavior in the male rat. Exp Brain Res 111, 35–40 (1996). https://doi.org/10.1007/BF00229553
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DOI: https://doi.org/10.1007/BF00229553