Abstract
A gene encoding the endogenous superantigen Mlsc, which deletes Tcrb-V3+ T cells in the NOD inbred mouse strain, was found to co-segregate with Mtv-3 on chromosome 11. This identifies a fourth gene encoding a deletion ligand for Tcrb-V3+ T cells and extends recently published observations in support of the hypothesis that a number of endogenous superantigens are the products of Mtv proviruses.
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Fairchild, S., Knight, A.M., Dyson, P.J. et al. Co-segregation of a gene encoding a deletion ligand for Tcrb-V3+ T cells with Mtv-3 . Immunogenetics 34, 227–230 (1991). https://doi.org/10.1007/BF00215257
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DOI: https://doi.org/10.1007/BF00215257