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Activation of mouse peritoneal macrophages by mannophosphoinositides of mycobacteria

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Abstract

Peritoneal macrophages isolated from mannoside-methylated bovine serum albumin (MBSA)-immunized mice showed significantly enhanced phagocytosis of Mycobacterium smegmatis compared to control or MBSA-immunized groups. Immune macrophages also exhibited bacteriostatic activity against M. smegmatis. Pretreatment of mycobacteria with mannoside antibodies did not further alter the phagocytosis and bacteriostatic effect of immune macrophages.

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Authors and Affiliations

  1. Department of Biochemistry, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India

    P. K. Mehta & Gopal K. Khuller

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  1. P. K. Mehta
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  2. Gopal K. Khuller
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Mehta, P.K., Khuller, G.K. Activation of mouse peritoneal macrophages by mannophosphoinositides of mycobacteria. Med Microbiol Immunol 178, 21–27 (1989). https://doi.org/10.1007/BF00202288

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  • DOI: https://doi.org/10.1007/BF00202288

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