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TaqI dimorphic site in a human pancreatic phospholipase A2 (PLA2) gene localized on chromosome 12

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Abstract

We report the identification of a TaqI dimorphic site in the first intron of a human phospholipase A2 gene that has been localized on chromosome 12. This single two-allele polymorphism was detected by DNA blot hybridization using a full-length, 584 bp human phospholipase A2 cDNA isolated from a human lung λgt10 cDNA library. Fragment lengths were detected at either 1.3 kb or 2.2 kb. The PIC value of this dimorphism was 0.369 in a random population of 353 Caucasians.

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References

  • Seilhamer JJ, et al (1986) Pancreatic phospholipase A2: isolation of the human gene and cDNAs from porcine pancreas and human lung. DNA 5:519–527.

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Authors and Affiliations

  1. Department of Pathology, FMHS, Al Ain, UAE

    P. M. Frossard & P. E. Newman

  2. Department of Dermatology, Tawam Hospital, Al Ain, UAE

    G. G. Lestringant

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  1. P. M. Frossard
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  2. P. E. Newman
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  3. G. G. Lestringant
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Frossard, P.M., Newman, P.E. & Lestringant, G.G. TaqI dimorphic site in a human pancreatic phospholipase A2 (PLA2) gene localized on chromosome 12. Hum Genet 93, 720 (1994). https://doi.org/10.1007/BF00201582

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  • DOI: https://doi.org/10.1007/BF00201582

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