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Structure and polymorphism of horse MHC class II DRB genes: convergent evolution in the antigen binding site

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References

  • Andersson, G., Larhammar, D., Widmark, E., Servenius, B., Peterson, P. A., and Rask, L. Class II genes of the human major histocompatibility complex: organization and evolutionary relationship of the DRß genes. J Biol Chem 262: 8748–8758, 1987

    Google Scholar 

  • Andersson, L., Sigurdardottir, S., Borsch, C., and Gustafsson, K. Evolution of MHC polymorphism: extensive sharing of polymorphic sequence motifs between human and bovine DRB alleles. Immunogenetics 33: 188–193, 1991

    Google Scholar 

  • Bell, J. I., Estess, P., St. John, Saiki, R., Watling, D. L., Ehrlich, H. A., and McDevitt, H. O. DNA sequence and characterization of human class II major histocompatibility complex \gB chains from the DR1 haplotype. Proc Natl Acad Sci USA 82: 3405–3409, 1985

    Google Scholar 

  • Bell, J. I., Denney, D. J., Foster, L., Belt, T., Todd, J. A., and McDevitt, H. O. Allelic variation in the DR subregion of the human major histocompatibility complex. Proc Natl Acad Sci USA 84: 6234–6238, 1987

    Google Scholar 

  • Denaro, M., Hammerling, U., Rask, L., and Peterson, P. A. The Ebß gene may have acted as the donor gene in a gene conversion-like event generating the Abm12ß mutant. EMBO J 7: 3745–3753, 1984

    Google Scholar 

  • Gustafsson, K., Wiman, K., Emmoth, E., Larhammar, D., Böhme, J., Hyldig-Nielsen, J. J., Ronne, H., Peterson, P. A., and Rask, L. Mutations and selection in the generation of class II histocompatibility antigen polymorphism. EMBO J 3: 1655–1661, 1984

    Google Scholar 

  • Gustafsson, K., Germana, S., Hirsch, F., Pratt, K., LeGuern, C., and Sachs, D. H. Structure of miniature swine class II DRB genes: conservation of hypervariable amino acid residues between distantly related species. Proc Natl Acad Sci USA 87: 9798–9802, 1990

    Google Scholar 

  • Lundberg, A. S. and McDevitt, H. O. Evolution of major histocompatibility complex class II diversity: direct descent in mice and humans. Proc Natl Acad Sci USA 89: 6545–6549, 1992

    Google Scholar 

  • Marsh, S. G. E. and Bodmer, J. G. HLA class II nucleotide sequences, 1992. Eur J Immunogenetics 20: 47–79, 1993

    Google Scholar 

  • Mengle-Gaw, L. and McDevitt, H. O. Predicted protein sequence of the murine I-EßS polypeptide chain from cDNA and genomic clones. Proc Natl Acad Sci USA 82: 2910–2914, 1983

    Google Scholar 

  • Robertson, K. A. and McMaster, W. R. Complete structure of a rat RT1 Eß chain: extensive conservation of MHC class II \gB chains. J Immunol 135: 4095–4099, 1985

    Google Scholar 

  • Sarmiento, U. M., Sarmiento, J. I., and Storb, R. Allelic variation in the DR subregion of the canine major histocompatibility complex. Immunogenetics 32: 13–19, 1990

    Google Scholar 

  • Sigurdardottir, S., Borsch, C., Gustafsson, K., and Andersson, L. Cloning and sequence analysis of 14 DRB1 alleles of the bovine MHC by using the polymerase chain reaction. Anim Genet 22: 199–209, 1991

    Google Scholar 

  • Spies, T., Sorrentino, R., Boss, J. M., Okada, K., and Strominger, J. L. Structural organization of the DR subregion of the human major histocompatibility complex. Proc Natl Acad Sci USA 82: 5165–5169, 1985

    Google Scholar 

  • Tonnelle, C., DeMars, R., and Long, E. O. DOß: a new β chain gene in HLA-D with a distinct regulation of expression. EMBO J 4: 2839–2847, 1985

    Google Scholar 

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The nucleotide sequence data reported in this paper have been submitted to the GenBank nucleotide sequence database and have been assigned the accession numbers L25644-25646.

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Gustafsson, K., Andersson, L. Structure and polymorphism of horse MHC class II DRB genes: convergent evolution in the antigen binding site. Immunogenetics 39, 355–358 (1994). https://doi.org/10.1007/BF00189233

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  • DOI: https://doi.org/10.1007/BF00189233

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