Abstract
MR imaging of the rat brain has become an increasingly frequently used method in experimental neuroradiology. On a generally available 1.5 T whole body tomograph, supplemented with an individually made small coil and a special SE sequence we obtained fairly fine images of the structures of the rat brain. With gadolinium-DTPA, we were able to visualize posterior fossa and cervical leptomeningeal growth of intrathecally injected B16 melanoma in nude rats. Using MRI to follow experimental leptomeningeal metastasis, may provide a new means for diagnostic evaluation and preclinical testing of treatment modalities.
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Martos, J., Petersen, D., Klose, U. et al. MR imaging of experimental meningeal melanomatosis in nude rats. J Neuro-Oncol 14, 207–211 (1992). https://doi.org/10.1007/BF00172596
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DOI: https://doi.org/10.1007/BF00172596