Summary
The interactions of talipexole (B-HT 920) and clonidine with selective α-adrenoceptor antagonists, yohimbine (a 2) and prazosin (a 1), as well as with dopamine receptor antagonists, metoclopramide (D2), domperidone (D2) and SCH23 390 (D1) were investigated in anaesthetized rabbits after i. v. administration.
Both talipexole (0.03–0.1 mg/kg) and clonidine (0.01–0.03 mg/kg) dose-dependently induced hypotension and bradycardia. Talipexole had a shorter duration of action.
The hypotensive effect of the α2-adrenoceptor and D2 agonist talipexole (0.03 mg/kg) was antagonized by pretreatment with metoclopramide (3 mg/kg) or domperidone (0.3–3 mg/kg),but not with yohimbine (3 mg/kg),prazosin (0.1 mg/kg) orSCH 23 390 (1 mg/kg). Its bradycardic effect was antagonized only by metoclopramide (3 mg/kg). The hypotensive and bradycardic effects of clonidine (0.03 mg/kg) were most effectively antagonized by yohimbine (0.3–3 mg/kg).
These findings indicate that in anaesthetized rabbits after i. v. administration, talipexole may lower blood pressure by peripheral, and heart rate by central, dopamine D2 agonism.
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Parts of the results were presented at the 33rd Spring Meeting of the German Pharmacological and Toxicological Society in Mainz, March 10–12, 1992 (Palluk R, Schilling JC, Stockhaus K, Peil H (1992) Naunyn-Schmiedeberg's Arch Pharmacol 345:R82)
Correspondence to R. Palluk at the above address
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Palluk, R., Schilling, J.C., Stockhaus, K. et al. Hypotensive and bradycardic effects of talipexole (B-HT 920) in anaesthetized rabbits are antagonized by metoclopramide but not by yohimbine. Naunyn-Schmiedeberg's Arch Pharmacol 348, 58–64 (1993). https://doi.org/10.1007/BF00168537
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DOI: https://doi.org/10.1007/BF00168537