Abstract
Twenty patients suspected of meningeal carcinomatosis (MC) secondary to small cell carcinoma of the lung were evaluated by myelography and by cytologic examination of cerebrospinal fluid (CSF). In 4 patients both investigations demonstrated MC. Four had positive cytology but a negative myelogram. Five patients had a positive myelogram but negative cytology. Thus 13 of the 20 patients had MC diagnosed by one or both of these investigations. Two additional patients suspected of MC were studied; both had positive myelography, but cytologic examination of CSF was not performed in either case. Six patients underwent autopsy with microscopic examination of the spinal cord; in all cases post-mortem findings supported myelographic findings. In conclusion, myelography is useful in the evaluation of patients suspected of MC secondary to small carcinoma of the lung and complements the diagnostic role of CSF examination.
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Wasserstrom WR, Glass JP, Posner JB: Diagnosis and treatment of leptomeningeal metastases from solid tumors: experience with 90 patients. Cancer 49:759–772, 1982.
Hirsch FR, Paulson OB, Hansen HH, Vraa-Jensen J: Intracranial metastases in small cell carcinoma of the lung. Cancer 50:2433–2437, 1982.
Brereton HD, O'Donnell JF, Kent CH, Matthews M, Dunnick NR, Johnson RE: Spinal meningeal carcinomatosis in small-cell carcinoma of the lung. Annals of Internal Medicine 88:517–519, 1978.
Nugent JL, Bunn Jr, PA, Matthews MJ, Ihde DC, Cohen MH, Gazdar A, Minna JD: CNS metastases in small cell bronchogeniccarcinoma. Increasing frequency and changing pattern with lengthening survival. Cancer 44:1885–1893, 1979.
Aisner J, Aisner SC, Ostrow S, Govindan S, Mummert K, Wiernik P: Meningeal carcinomatosis from small cell carcinoma of the lung. Consequence of improved survival. Acta Cytologica 23:292–294, 1979.
Rosen ST, Aisner J, Makuch RW, Matthews MJ, Ihde DC, Whitacre MRN, Glatstein EJ, Wiernik PH, Lichter AS, Bunn PA: Carcinomatous leptomeningitis in small cell lung cancer: a clinicopathologic review of the National Cancer Institute Experience. Medicine 61:45–53, 1982.
Jacobsen HH, Lester J: A myelographic manifestation of diffuse spinal leptomeningeal melanomatosis. Neuroradiology 1:30–31, 1970.
Paulson OB, Nielsen H, Brodersen P: Meningeal carcinomatosis demonstrated by myelography using water soluble contrast material. In: Whitehouse JMA, Kay HEM (eds) CNS complications of malignant disease. The MacMillan Press LTD, London, 1979, pp 324–326.
Choi HH, Anderson PJ: Diagnostic cytology of cerebrospinal fluid by the cytocentrifuge method. Am J Clin Pathol 72:931–943, 1979.
Glass JP, Melamed M, Chernik NL, Posner JB: Malignant cells in the cerebrospinal fluid (CSF): the meaning of a CSF cytology. Neurology 29:1369–1375, 1979.
Pedersen AG, Nielsen H, Paulson OB: Metrizamid myelography in patients with meningeal carcinomatosis. Acta Neurol Scand 65 (suppl) 90:100, 1982 (Abstract).
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Pedersen, A.G., Paulson, O.B. & Gyldensted, C. Metrizamide myelography in patients with small cell carcinoma of the lung suspected of meningeal carcinomatosis. J Neuro-Oncol 3, 85–89 (1985). https://doi.org/10.1007/BF00165176
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DOI: https://doi.org/10.1007/BF00165176