Abstract
The influence of dietary iron deficiency on acute nickel, lead or cadmium toxicity as reflected by the induction of hepatic, renal and intestinal metallothionein (MT), disposition of the metals, and alterations in hematological parameters was investigated in rats. The administration of cadmium induced the hepatic, renal and intestinal MT while that of nickel or lead induced hepatic MT only. However, dietary iron deficiency did not influence the cadmium induced tissue MT but enhanced the ability of nickel or lead to restore the normal synthesis of renal and intestinal MT lowered under the influence of reduced body iron status. The accumulation of lead in liver and kidney and that of cadmium enhanced in liver only, while tissue deposition of nickel remained unaffected by iron deficiency. The induction of hepatic MT by three metals appears related to the concomitant rise in the hepatic zinc, calcium and iron levels in normal rats. However, dietary iron deficiency increased the hepatic zinc in response to nickel or cadmium and that of heptic calcium in response to lead.
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References
Baynes RD, Bothwell TH. 1990 Iron deficiency. Annu Rev Nutr 10, 133–148.
Bremner I. 1987 Nutritional and physiological significance of metallothionein. In: Kagi HR, Kojima Y, eds. Metallothionein II. Basel: Birkhauser; 81.
Bremner I, Beattie JH. 1990 Metallothionein and the trace minerals. Annu Rev Nutr 10, 63–83.
Clark M, Royal J, Seeler R. 1988 Interaction of iron deficiency and lead and the hematological findings in children with severe lead poisoning. Pediatrics 81, 247–254.
Clegg JW, King EJ. 1942 Estimation of hemoglobin by the alkaline hematin method. Br Med J 2, 329–333.
Cousins RJ. 1985 Absorption, transport and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin. Physiol Rev 65, 238–309.
Eaton DL, Toal BF. 1982 Evaluation of Cd/hemoglobin affinity assay for the rapid determination of metallothionein in biological tissues. Toxicol Appl Pharmacol 66, 134–142.
Eaton DL, Stacey NH, Wong KL, Klaassan CD. 1980 Dose response effect of various metal ions on rat liver metallothionein, glutathione, heme oxygenase and cytochrome p-450. Toxicol Appl Pharmacol 55, 393–402.
Elsenhans B, Schmolke G, Kolb K, Stokes J, Forth W. 1987 Metal-metal interactions among dietary toxic and essential trace metals in the rat. Ecotoxicol Environ Safety 14, 275–287.
Hashmi NS, Kachru DN, Khandelwal S, Tandon SK. 1989a Interrelationship between iron deficiency and lead intoxication (II). Biol Trace Elem Res 22, 299–307.
Hashmi NS, Kachru DN, Tandon SK. 1989b Interrelationship between iron deficiency and lead intoxication (I). Biol Trace Elem Res 22, 287–297.
Hidalgo J, Giralt M, Garvey JS, Armario A. 1988 Physiological role of glucocortincoids on rat serum and liver metallothionein in basal and stress conditions. Am J Physiol 254, 71–78.
Keele CA, Neil E. 1966 Samsons Wright's ‘Applied Physiology’, 2nd edn. London: Oxford University Press; 12.
Khandelwal S, Flora SJS, Tandon SK. 1990 Nickel-selenium interaction—time dependent biochemical alterations and metal decorporation in rats. Chem-Biol Interact 75, 341–347.
Maitani T, Watahiki A, Suzuki KT. 1986 Induction of metallothionein after lead administration by three injection routes in mice. Toxicol Appl Pharmacol 83, 211–217.
Mathur AK, Tandon SK. 1979 Some biochemical alterations in early nickel toxicity. Chemosphere 8, 893–901.
McCormick CC. 1984 The tissue-specific accumulation of hepatic zinc metallothionein following parenteral iron loading. Proc Soc Exp Biol Med 176, 392–402.
Peters T, Giovanniello TJ, Apt L, Ross JF. 1956 A new method for the determination of serum iron II. J Lab Clin Med 48, 280–288.
Ragan HA. 1977 Effects of iron deficiency on absorption and distribution of lead and cadmium in rats. J Lab Clin Med 90, 700–706.
Ribas B, Brenes MA, De Pascual FJ, Del Rio J, Sanchez-Reus MI. 1987 Participation of metallothionein and cerebral structures in iron homeostasis of anemic rats. In: Bratter P, Schramel P, eds. Trace Element-Analytical Chemistry in Medicine and Biology, Vol. 4. Berlin: Walter de Gruyter; 317.
Robertson A, Morrison JN, Wood AM, Bremner I. 1989 Effects of iron deficiency on metallothionein-I concentrations in blood and tissues of rats. J Nutr 119, 439–445.
Schafer SG, Forth W. 1985 The interaction between cadmium and iron: a review of the literature. Trace Elem Med 2, 158–162.
Schafer SG, Schwegler U, Schumann K. 1990 Retention of cadmium in cadmium-naive normal and iron deficient rats as well as in cadmium-induced iron-deficient animals. Ecotoxicol Environ Safety 20, 71–81.
Waalkes MP, Klaassen CD. 1985 Concentration of metallothionein in major organs of rats after administration of various metals. Fund Appl Toxicol 5, 473–477.
Yamane Y, Fukuchi M, Li C, Koizumi T. 1990 Protective effect of sodium molybdate against the acute toxicity of cadmium chloride. Toxicology 60, 235–243.
Yoshikawa H, Ohsawa M, Kaneta M. 1974 Clinicochemical studies on subacute cadmium poisoning in rabbits. Ind Health 12, 127–140.
Zar JH. 1984 Biostatistical Analysis, 2nd edn. Englewood Cliffs, NJ: Prentice Hall; 194–195.
Zlatkis A, Zak B, Boyle AJ. 1953 A new method for the direct determination of serum cholesterol. J Lab Clin Med 41, 486–492.
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Tandon, S.K., Khandelwal, S., Jain, V.K. et al. Influence of dietary iron deficiency on acute metal intoxication. Biometals 6, 133–138 (1993). https://doi.org/10.1007/BF00140115
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DOI: https://doi.org/10.1007/BF00140115