Abstract
Sister chromatid exchange rate was studied in 12 early diagnosed cases of nasopharyngeal carcinoma and in their paired controls. Exchange frequencies were also analyzed in 100 healthy subjects distributed in four regions of Hunan Province and correlated to nationality, age and sex. The incidence of sister chromatid exchange was significantly higher in the cancer patients than in the normal controls. No correlation was found between the frequency of sister chromatid exchange and region, nationality, age or sex.
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Abbreviations
- NPCC:
-
nasopharyngeal carcinoma
- SCEE:
-
sister chromatid exchange
References
CHAGANTI, R.S.K., SCHOUBERG, S. and GERMAN, J. (1974). A many fold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes. Proc. Natl. Acad. Sci. USA71:4508–4512.
LI, G.Y. and HU, Y.C.(1983). A preliminary study on factors influencing sister chromatid exchange in patients with nasopharyngeal carcinoma. Bull. Hunan Med. College8:272–283.
OU, B.X. (1980). Sister chromatid exchanges in lymphocytes from patients with nasopharyngeal carcinoma. Acta Acad. Med. Zhong Shan1:43–46.
PERRY, P. and WOLFF, S. (1974). New Giemsa method for the differential staining of sister chromatids. Nature (Lond.)251:156–158.
YAO, K.T. (1982). Epidemiological characteristics and carcinogenesis of nasopharyngeal carcinoma in Hunan Province- Based on 1973–1975 Cancer Mortality Survey. Bull. Hunan Med. College7:10–17.
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Hu, Y., Li, G., Peng, L. et al. Sister chromatid exchanges in lymphocytes of early cases of nasopharyngeal carcinoma and in 100 healthy subjects. Cell Biol Toxicol 3, 321–325 (1987). https://doi.org/10.1007/BF00117868
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DOI: https://doi.org/10.1007/BF00117868