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CT assessment of tumor heterogeneity and the potential for the prediction of human papillomavirus status in oropharyngeal squamous cell carcinoma

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Abstract

The aim of this study is to find a correlation between tumoral heterogeneity of squamous cell carcinoma of the oropharynx and human papillomavirus (HPV) status and to determine whether analysis of texture features of primary lesion on contrast-enhanced CT (CECT) images can be useful in predicting the HPV positivity. Fifty patients with diagnosis of oropharyngeal carcinoma and pre-treatment CECT were included; tumoral heterogeneity of each lesion was evaluated by extracting quantitative texture parameters of first and higher orders. T test and logistic regression were conducted to evaluate the effects of different textural characteristics. There were 35 HPV+ and 15 HPV− lesions. Statistically significant (p < 0.05) differences were seen in multiple higher-order extracted parameters. The logistic regression model correctly classified lesions with an accuracy of 95.2%. CT texture analysis of primary oropharyngeal cancer may be used as a tool for predicting the HPV status.

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Authors and Affiliations

  1. Department of Radiology, Careggi University Hospital, University of Florence, Largo G.A. Brambilla 3, 50134, Florence, Italy

    Francesco Mungai, Giovanni Battista Verrone, Gloria Addeo, Luigi Bonasera & Vittorio Miele

  2. Radiodiagnostic Unit n. 2, Department of Biomedical, Experimental and Clinical Sciences, Careggi University Hospital, University of Florence, Largo G.A. Brambilla 3, 50134, Florence, Italy

    Michele Pietragalla

  3. Nuclear Medicine Unit, Department of Biomedical, Experimental and Clinical Sciences, Careggi University Hospital, University of Florence, Largo G.A. Brambilla 3, 50134, Florence, Italy

    Valentina Berti

  4. Radiation Oncology Unit, Careggi University Hospital, University of Florence, Largo G.A. Brambilla 3, 50134, Florence, Italy

    Isacco Desideri

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  1. Francesco Mungai
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  2. Giovanni Battista Verrone
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Correspondence to Luigi Bonasera.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.

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Mungai, F., Verrone, G.B., Pietragalla, M. et al. CT assessment of tumor heterogeneity and the potential for the prediction of human papillomavirus status in oropharyngeal squamous cell carcinoma. Radiol med 124, 804–811 (2019). https://doi.org/10.1007/s11547-019-01028-6

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  • DOI: https://doi.org/10.1007/s11547-019-01028-6

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