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Evaluation of the cytoprotective effects of bovine lactoferrin against intestinal toxins using cellular model systems

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Abstract

Lactoferrin is an iron-binding glycoprotein that exhibits a range of health benefits including immune regulation and disease prevention derived from its structural properties. The present study employed immune cell models and a colon epithelial cell model to investigate the protective effects of bovine lactoferrin (BLf) on both immune cells and colon epithelium cells. BLf caused significant reduction of faecal genotoxin-induced DNA damage in HT29 cells, and down-regulation of lipopolysaccharide (LPS)-induced macrophage cell stress and endotoxic response, in an infection status.

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Acknowledgments

This work was funded by a Technology in Industry Fellowship to H.T., awarded by the New Zealand Foundation for Research, Science and Technology, and by Drapac Ltd. The experimental work was carried out by H.T. under the supervision of her PhD supervisors, I.S.M, L.R.F and Q.S. All authors contributed to the manuscript. There are no conflicts of interest.

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Authors and Affiliations

  1. School of Engineering and Advanced Technology, College of Sciences, Massey University, Auckland, New Zealand

    Hong Tian & Ian S. Maddox

  2. Department of Nutrition, School of Medical Sciences, The University of Auckland, Auckland, New Zealand

    Lynnette R. Ferguson

  3. Bioactives Research New Zealand, Auckland, New Zealand

    Hong Tian & Quan Shu

Authors
  1. Hong Tian
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  2. Ian S. Maddox
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  3. Lynnette R. Ferguson
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  4. Quan Shu
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Correspondence to Ian S. Maddox.

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Tian, H., Maddox, I.S., Ferguson, L.R. et al. Evaluation of the cytoprotective effects of bovine lactoferrin against intestinal toxins using cellular model systems. Biometals 23, 589–592 (2010). https://doi.org/10.1007/s10534-010-9301-9

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  • DOI: https://doi.org/10.1007/s10534-010-9301-9

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