Abstract
Cough is an airway defensive reflex consisting of an inspiratory phase followed by a forced expiratory effort initially against a closed glottis, followed by active glottal opening and rapid expiratory flow. The expiration reflex (ER) differentiates from cough for the lack of a preparatory inspiration. The reflexes subserve different functions: cough will clear the lower airways from debris and mucus, while the expiration reflex will prevent aspiration. Clinically, a cough epoch is a sequence of motor acts resulting from a combination of true coughs and ERs that need to be accurately identified and measured for adequate quantitative description.
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References
Anonymous (1973) The Shorter Oxford English Dictionary 3rd ed. Oxford: Clarendon Press, p 436
Morice AH, McGarvey L, Pavord I (2006) Recommendations for the management of cough in adults. Thorax 61(Suppl 1):1–24
Morice AH, Fontana GA, Belvisi MG, Birring SS, Chung KF, Dicpinigaitis PV, Kastelik JA, McGarvey LP, Smith JA, Tatar M, Widdicombe J, European Respiratory Society (2007) ERS guidelines on the assessment of cough. Eur Respir J 29:1256–1276
Korpas J, Tomori Z (1979) Cough and Other Respiratory Reflexes. Basel: Karger, pp 1–281
Leith DE (1977) Cough. In: Brain JD, Proctor DF, Reid LM (eds) Respiratory defense mechanisms. New York: Marcel Dekker, pp 545–592
Williams CBJ (1841) Report of experiments on the physiology of the lungs and air-tubes. Rep Br Assn Adv Sci August: 411–420
Shannon R, Baekey DM, Morris KF, Nuding SC, Segers LS, Lindsey BG (2004) Production of reflex cough by brainstem respiratory networks. Pulm Pharmacol Ther 6:369–381
Baekey DM, Morris KF, Nuding SG, Segars LS, Lindsey BG, Shannon R (2004) Ventrolateral medullary respiratory network participation in the expiration reflex in the cat. J Appl Physiol 96:2057–2072
Widdicombe J, Fontana G (2006) Cough: what’s in a name? Eur Respir J 28:10–15
Tatar M, Hanacek J, Widdicombe J (2007) The expiration reflex from the trachea and bronchi. Eur Respir J (in press)
Nishino T, Tagaito Y, Isono S (1996) Cough and other reflexes on irritation of airway mucosa in man. Pulm Pharmacol 9:285–292
Young S, Abdul-Sattar N, Caric D (1987) Glottic closure and high flows are not necessary for productive cough. Bull Eur Physiolpathol Respir 23(Suppl 10):13S–17S
Davenport PW, Sapienza CM, Bolser DC (2002) Psychophysical assessment of the urge-to-cough. Eur Respir Rev 12:249–253
Hsu J-Y, Stone RA, Logan-Sinclair R, Worsdell M, Busst C, Chung KF (1994) Coughing frequency in patients with persistent cough using a 24-hour ambulatory recorder. Eur Respir J 7:1246–1253
Barry SJ, Dane AD, Morice AH, Walmsley AD (2006) The automatic recognition and counting of cough. Cough 2:8
Morata A, Ohota N, Shibuya A, Ono H, Kudoh S (2006) New non-invasive automatic cough counting program based on 6 types of classified cough sounds. Intern Med 45:391–397
Smith J (2007) Ambulatory methods for recording cough. Pulm Pharmacol Ther 20(4):313–318
Bucher K (1958) Pathophysiology and pharmacology of cough. Pharm Rev 10:43–58
Strohl KP, Mead J, Banzett RB, Loring S, Kosch P (1981) Regional differences in abdominal muscle activity during various maneuvres in humans. J Appl Physiol 51:1471–1476
De Troyer A, Loring SH (1986) Action of respiratory muscles. In: Handbook of Physiology. The Respiratory System. Mechanics of Breathing. Bethesda, MD: Am Physiol Soc, sect 3, vol III, chap 27, pp 1–67
Fontana GA, Pantaleo T, Lavorini F, Boddi V, Panuccio P (1997) A non-invasive electromyographic study on threshold and intensity of cough in humans. Eur Respir J 10:983–989
Fontana GA, Pantaleo T, Lavorini F, Polli G, Pistolesi M (1999) Coughing in laryngectomized patients. Am J Respir Crit Care Med 160:1578–1584
Fontana GA, Pantaleo T, Lavorini F, Benvenuti F, Gangemi S (1998) Defective motor control of coughing in Parkinson’s disease. Am J Respir Crit Care Med 158:458–464
Lavorini F, Pantaleo T, Geri P, Mutolo D, Pistolesi M, Fontana GA (2007) Cough and ventilatory adjustments evoked by aerosolised capsaicin and distilled water (fog) in man. Respir Physiol Neurobiol 156:331–339
Desmedt JE, Godaux E (1977) Ballistic contractions in man: characteristic recruitment pattern of single motor units in the tibialis anterior muscle. J. Physiol 264:673–693
Bigland B, Lippold OCJ (1954) The relation between force, velocity and integrated electrical activity in human muscles. J Physiol (Lond) 123:214–224
Fontana GA (2003) Motor mechanisms and the mechanics of cough. In: Chung F, Widdicombe J, Boushey H (eds) Cough: Causes, Mechanisms and Therapy. Oxford: Blackwell Publishing, pp 193–205
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The author is grateful to Prof. John Widdicombe who has inspired many of the concepts presented in this article.
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Fontana, G.A. Before We Get Started: What Is a Cough?. Lung 186 (Suppl 1), 3–6 (2008). https://doi.org/10.1007/s00408-007-9036-8
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DOI: https://doi.org/10.1007/s00408-007-9036-8