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Association between omentin-1 and indices of glucose metabolism in early pregnancy: a pilot study

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

Omentin-1 plays an important role in regulating insulin sensitivity outside pregnancy. As an adipokine derived from human placental and adipose tissue, it may be an important contributor in the biological pathway of gestational diabetes.

Methods

Omentin-1 was measured in a sub-cohort of 50 participants in the Omega study.

We aimed to evaluate whether circulating maternal omentin-1 concentrations are associated with fasting serum glucose, insulin, HOMA-IR and maternal obesity as measured by body mass index (BMI) and subcutaneous and intra-abdominal fat thickness measurements in normoglycemic pregnant participants. We performed a subgroup analysis by BMI category.

Results

Omentin-1 was negatively correlated with HOMA-IR and insulin and inversely associated with serum glucose concentration in the fully adjusted model (− 47%; slope per tertile increase in concentration − 0.19; P-trend 0.01). This association was significant in non-overweight/obese (< 25 kg/m2) but not among overweight/obese (≥ 25 kg/ m2) participants. The association with serum insulin was not significant in the fully adjusted model.

Conclusion

Circulating omentin-1 concentrations are inversely associated with serum glucose concentrations. Although the relevance of these findings remains to be elucidated, they may indicate a mechanism for the development of insulin resistance and gestational diabetes. Follow-up studies with larger sample sizes are warranted.

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References

  1. Cunningham FL, Bloom KJ, Hauth SL, Rouse JC, Spong DJ, CY Williams Obstetrics, ed. (2010) M.H. 23nd ed. USA

  2. Hill M (2005) Mater Physiol 107–31.

  3. Badon SE et al (2017) Healthy lifestyle during early pregnancy and risk of gestational diabetes mellitus. Am J Epidemiol 186(3):326–333

    Article  PubMed  PubMed Central  Google Scholar 

  4. Ruchat SM, Hivert MF, Bouchard L (2013) Epigenetic programming of obesity and diabetes by in utero exposure to gestational diabetes mellitus. Nutr Rev 71(Suppl 1):S88–S94

    Article  PubMed  Google Scholar 

  5. Fasshauer M, Bluher M, Stumvoll M (2014) Adipokines in gestational diabetes. Lancet Diabetes Endocrinol 2(6):488–499

    Article  CAS  PubMed  Google Scholar 

  6. Bozkurt L et al (2018) Adiponectin and leptin at early pregnancy: association to actual glucose disposal and risk for gdm-a prospective cohort study. Int J Endocrinol 2018:5463762

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Ouchi N et al (2011) Adipokines in inflammation and metabolic disease. Nat Rev Immunol 11(2):85–97

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Catalano PM et al (2006) Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism. Diabetologia 49(7):1677–1685

    Article  CAS  PubMed  Google Scholar 

  9. Ahlsson F et al (2013) Adipokines and their relation to maternal energy substrate production, insulin resistance and fetal size. Eur J Obstet Gynecol Reprod Biol 168(1):26–29

    Article  CAS  PubMed  Google Scholar 

  10. Ortega-Senovilla H et al (2011) Gestational diabetes mellitus causes changes in the concentrations of adipocyte fatty acid-binding protein and other adipocytokines in cord blood. Diabetes Care 34(9):2061–2066

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Saucedo R et al (2011) Relationship between circulating adipokines and insulin resistance during pregnancy and postpartum in women with gestational diabetes. Arch Med Res 42(4):318–323

    Article  CAS  PubMed  Google Scholar 

  12. de Gennaro G et al (2019) The role of adipokines in the pathogenesis of gestational diabetes mellitus. Gynecol Endocrinol 35(9):737–751

    Article  PubMed  CAS  Google Scholar 

  13. Abell SK et al (2017) The association between dysregulated adipocytokines in early pregnancy and development of gestational diabetes. Diabetes Metab Res Rev 33(8):e2926

    Article  CAS  Google Scholar 

  14. Bellos I et al (2019) Serum levels of adipokines in gestational diabetes: a systematic review. J Endocrinol Invest 42(6):621–631

    Article  CAS  PubMed  Google Scholar 

  15. Franz M et al (2018) Maternal and neonatal omentin-1 levels in gestational diabetes. Arch Gynecol Obstet 297(4):885–889

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Aktas G et al (2014) Association between omentin levels and insulin resistance in pregnancy. Exp Clin Endocrinol Diabetes 122(3):163–166

    Article  CAS  PubMed  Google Scholar 

  17. Kafalidis G et al (2013) Adipokines vaspin and omentin-1 are up-regulated in large for gestational age infants at term. Cytokine 62(1):70–74

    Article  CAS  PubMed  Google Scholar 

  18. Brandt B et al (2015) Omentin, an adipokine with insulin-sensitizing properties, is negatively associated with insulin resistance in normal gestation. J Perinat Med 43(3):325–331

    Article  CAS  PubMed  Google Scholar 

  19. Schaffler A et al (2005) Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue. Biochim Biophys Acta 1732(1–3):96–102

    Article  CAS  PubMed  Google Scholar 

  20. Yang RZ et al (2006) Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. Am J Physiol Endocrinol Metab 290(6):E1253–E1261

    Article  CAS  PubMed  Google Scholar 

  21. Pan HY, Guo L, Li Q (2010) Changes of serum omentin-1 levels in normal subjects and in patients with impaired glucose regulation and with newly diagnosed and untreated type 2 diabetes. Diabetes Res Clin Pract 88(1):29–33

    Article  CAS  PubMed  Google Scholar 

  22. Tan BK et al (2008) Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose. Diabetes 57(4):801–808

    Article  CAS  PubMed  Google Scholar 

  23. de Souza Batista CM et al (2007) Omentin plasma levels and gene expression are decreased in obesity. Diabetes 56(6):1655–1661

    Article  PubMed  CAS  Google Scholar 

  24. Pan X et al (2019) Omentin-1 in diabetes mellitus: a systematic review and meta-analysis. PLoS ONE 14(12):e0226292

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. As Habi A et al (2019) The association between omentin and diabetes: a systematic review and meta-analysis of observational studies. Diabetes Metab Syndr Obes 12:1277–1286

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Rudra CB et al (2008) A prospective analysis of recreational physical activity and preeclampsia risk. Med Sci Sports Exerc 40(9):1581–1588

    Article  PubMed  Google Scholar 

  27. Matthews DR et al (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28(7):412–419

    Article  CAS  PubMed  Google Scholar 

  28. Armellini F et al (1990) The contribution of sonography to the measurement of intra-abdominal fat. J Clin Ultrasound 18(7):563–567

    Article  CAS  PubMed  Google Scholar 

  29. Armellini F et al (1993) Total and intra-abdominal fat measurements by ultrasound and computerized tomography. Int J Obes Relat Metab Disord 17(4):209–214

    CAS  PubMed  Google Scholar 

  30. Elsaid NH et al (2018) Serum omentin-1 levels in type 2 diabetic obese women in relation to glycemic control, insulin resistance and metabolic parameters. J Clin Transl Endocrinol 13:14–19

    PubMed  PubMed Central  Google Scholar 

  31. Cai RC et al (2009) Expression of omentin in adipose tissues in obese and type 2 diabetic patients. Zhonghua Yi Xue Za Zhi 89(6):381–384

    CAS  PubMed  Google Scholar 

  32. Komosinska-Vassev K et al (2019) Circulating C1q/TNF-related protein 3, Omentin-1 and NGAL in obese patients with type 2 diabetes during insulin therapy. J Clin Med 8(6):805

    Article  CAS  PubMed Central  Google Scholar 

  33. Yan P et al (2011) Changes of serum omentin levels and relationship between omentin and adiponectin concentrations in type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes 119(4):257–263

    Article  CAS  PubMed  Google Scholar 

  34. Tan BK et al (2008) Decreased plasma omentin-1 levels in Type 1 diabetes mellitus. Diabet Med 25(10):1254–1255

    Article  CAS  PubMed  Google Scholar 

  35. Motawi TMK et al (2018) Serum levels of chemerin, apelin, vaspin, and omentin-1 in obese type 2 diabetic Egyptian patients with coronary artery stenosis. Can J Physiol Pharmacol 96(1):38–44

    Article  CAS  PubMed  Google Scholar 

  36. Dayem SM, Battah AA, Shehaby AE (2015) Cardiac affection in type 1 diabetic patients in relation to Omentin. Open Access Maced J Med Sci 3(4):699–704

    Article  PubMed  PubMed Central  Google Scholar 

  37. Nurten E et al (2018) Omentin-1 and NAMPT serum concentrations are higher and CK-18 levels are lower in children and adolescents with type 1 diabetes when compared to healthy age, sex and BMI matched controls. J Pediatr Endocrinol Metab 31(9):959–969

    Article  CAS  PubMed  Google Scholar 

  38. Barker G et al (2012) Omentin-1 is decreased in maternal plasma, placenta and adipose tissue of women with pre-existing obesity. PLoS ONE 7(8):e42943

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Briana DD et al (2011) Omentin-1 and vaspin are present in the fetus and neonate, and perinatal concentrations are similar in normal and growth-restricted pregnancies. Metabolism 60(4):486–490

    Article  CAS  PubMed  Google Scholar 

  40. Tsiotra PC et al (2018) Circulating adipokines and mRNA expression in adipose tissue and the placenta in women with gestational diabetes mellitus. Peptides 101:157–166

    Article  CAS  PubMed  Google Scholar 

  41. Moreno-Navarrete JM et al (2011) Circulating omentin as a novel biomarker of endothelial dysfunction. Obesity (Silver Spring) 19(8):1552–1559

    Article  CAS  Google Scholar 

  42. Auguet T et al (2011) New adipokines vaspin and omentin. Circulating levels and gene expression in adipose tissue from morbidly obese women. BMC Med Genet 12:60

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Tang YL et al (2017) Circulating omentin-1 levels in women with polycystic ovary syndrome: a meta-analysis. Gynecol Endocrinol 33(3):244–249

    Article  CAS  PubMed  Google Scholar 

  44. Lamain-de Ruiter M et al (2017) Prediction models for the risk of gestational diabetes: a systematic review. Diagn Progn Res 1:3

    Article  PubMed  PubMed Central  Google Scholar 

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Funding

No funding was obtained for this study.

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Authors and Affiliations

  1. Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA

    Stefania Papatheodorou, Bizu Gelaye & Michelle A. Williams

  2. Department of Psychiatry, Harvard Medical School, Boston, MA, USA

    Bizu Gelaye

  3. The Chester M. Pierce, M.D. Division of Global Psychiatry, Massachusetts General Hospital, Boston, MA, USA

    Bizu Gelaye

Authors
  1. Stefania Papatheodorou
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  2. Bizu Gelaye
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  3. Michelle A. Williams
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Contributions

SP: project development, data analysis, manuscript writing. BG: project development, data collection, manuscript writing. MW: project development, data collection, manuscript writing.

Corresponding author

Correspondence to Stefania Papatheodorou.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Papatheodorou, S., Gelaye, B. & Williams, M.A. Association between omentin-1 and indices of glucose metabolism in early pregnancy: a pilot study. Arch Gynecol Obstet 305, 589–596 (2022). https://doi.org/10.1007/s00404-021-06197-2

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  • DOI: https://doi.org/10.1007/s00404-021-06197-2

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