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Therapy and differential diagnosis of posterior reversible encephalopathy syndrome (PRES) during pregnancy and postpartum

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Abstract

Purpose

Posterior reversible encephalopathy syndrome (PRES) is an usually reversible neuro-radiological clinical entity characterized by headache, confusion, visual disturbances or blindness and seizures. It rarely occurs without seizures.

Methods

We conducted a literature review in MEDLINE about PRES during post partum and pregnancy, focusing on differential diagnosis and therapy. We reviewed 28 articles (case reports, original articles and reviews) describing PRES as well as a case of a severe, immediate postpartum HELLP syndrome (haemolysis, elevated liver enzyme levels, low platelet count) with PRES without generalized seizure.

Results

The development of PRES after delivery is unusual. Magnetic resonance imaging represents the gold standard for the diagnosis of this condition. White matter oedema in the posterior cerebral hemispheres is typical on neuroimaging. PRES is reversible when early diagnosis is established and appropriate treatment is started without delay. The pathogenesis of PRES is discussed and the importance of a prompt diagnosis is emphasized, as the crucial role of rapid blood press reduction.

Conclusion

MRI is the diagnostic gold standard and it may be useful in the differential diagnosis. The goal of the therapy is to control elevated blood pressure and to prevent seizures or promptly manage it.

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Conflict of interest

The authors did not report any potential conflicts of interest. I would like to warmly thank Joel Contreras and Giovanna Carriero for reviewing the English of the manuscript and for valuable advice.

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Authors and Affiliations

  1. Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Largo Brambilla, 350134, Florence, Italy

    Mauro Cozzolino, Claudia Bianchi, Giulia Mariani, Laura Marchi, Massimiliano Fambrini & Federico Mecacci

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  1. Mauro Cozzolino
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  2. Claudia Bianchi
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Correspondence to Mauro Cozzolino.

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Cozzolino, M., Bianchi, C., Mariani, G. et al. Therapy and differential diagnosis of posterior reversible encephalopathy syndrome (PRES) during pregnancy and postpartum. Arch Gynecol Obstet 292, 1217–1223 (2015). https://doi.org/10.1007/s00404-015-3800-4

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  • DOI: https://doi.org/10.1007/s00404-015-3800-4

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