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Clinical, Laboratorial, and Urodynamic Findings of Prostatic Artery Embolization for the Treatment of Urinary Retention Related to Benign Prostatic Hyperplasia. A Prospective Single-Center Pilot Study

  • Clinical Investigation
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Abstract

Purpose

This study was designed to describe the clinical, laboratorial, and urodynamic findings of prostatic artery embolization (PAE) in patients with urinary retention due to benign prostatic hyperplasia (BPH).

Methods

A prospective study of 11 patients with urinary retention due to BPH was conducted. Patients underwent physical examination, prostate specific antigen (PSA) measurement, transrectal ultrasound, and magnetic resonance imaging. International prostate symptom score (IPSS), quality of life (QoL), and urodynamic testing were used to assess the outcome before and after 1 year.

Results

Clinical success was 91 % (10/11 patients) with a mean follow-up of 22.3 months (range, 12–41 months). At the first year follow-up, the mean IPSS score was 2.8 points (p = 0.04), mean QoL was 0.4 points (p = 0.001), mean PSA decreased from 10.1 to 4.3 ng/mL (p = 0.003), maximum urinary flow (Qmax) improved from 4.2 to 10.8 mL/sec (p = 0.009), and detrusor pressure (Pdet) decreased from 85.7 to 51.5 cm H2O (p = 0.007). Before PAE, Bladder Outlet Obstruction Index (BOOI) showed values >40 in 100 % of patients. After PAE, 30 % of patients were >40 (obstructed), 40 % were between 20 and 40 (undetermined), and 30 % were <20 (unobstructed). Patients with a BOOI <20 had higher PSA values at 1-day after PAE.

Conclusions

Clinical and urodynamic parameters improved significantly after PAE in patients with acute urinary retention due to BPH. Total PSA at day 1 after PAE was higher in patients with unobstructed values in pressure flow studies.

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Conflict of interest

Alberto Azoubel Antunes, Francisco Cesar Carnevale, Joaquim Mauricio da Motta-Leal-Filho, Eduardo Muracca Yoshinaga, Luciana Mendes de Oliveira Cerri, Ronaldo Hueb Baroni, Antonio Sergio Zafred Marcelino, Giovanni Guido Cerri, Miguel Srougi have no conflict of interest.

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Authors and Affiliations

  1. Division of Urology, University of Sao Paulo Medical School, Av. Dr. Enéas de Carvalho Aguiar, 255, São Paulo, SP, 05403-001, Brazil

    Alberto A. Antunes, Eduardo M. Yoshinaga & Miguel Srougi

  2. Interventional Radiology Unit, University of Sao Paulo Medical School, Av. Dr. Enéas de Carvalho Aguiar, 255, São Paulo, SP, 05403-001, Brazil

    Francisco C. Carnevale & Joaquim M. da Motta Leal Filho

  3. Ultrasound Unit, University of Sao Paulo Medical School, Av. Dr. Enéas de Carvalho Aguiar, 255, São Paulo, SP, 05403-001, Brazil

    Luciana M. O. Cerri & Antonio S. Z. Marcelino

  4. Magnetic Resonance Unit, University of Sao Paulo Medical School, Av. Dr. Enéas de Carvalho Aguiar, 255, São Paulo, SP, 05403-001, Brazil

    Ronaldo H. Baroni

  5. Radiology Department, University of Sao Paulo Medical School, Av. Dr. Enéas de Carvalho Aguiar, 255, São Paulo, SP, 05403-001, Brazil

    Giovanni G. Cerri

  6. Rua Barata Ribeiro, 490, cj.76, São Paulo, 01308-000, Brazil

    Alberto A. Antunes

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  1. Alberto A. Antunes
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  2. Francisco C. Carnevale
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  3. Joaquim M. da Motta Leal Filho
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  4. Eduardo M. Yoshinaga
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  5. Luciana M. O. Cerri
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  6. Ronaldo H. Baroni
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  7. Antonio S. Z. Marcelino
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  8. Giovanni G. Cerri
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  9. Miguel Srougi
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Corresponding author

Correspondence to Francisco C. Carnevale.

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Antunes, A.A., Carnevale, F.C., da Motta Leal Filho, J.M. et al. Clinical, Laboratorial, and Urodynamic Findings of Prostatic Artery Embolization for the Treatment of Urinary Retention Related to Benign Prostatic Hyperplasia. A Prospective Single-Center Pilot Study. Cardiovasc Intervent Radiol 36, 978–986 (2013). https://doi.org/10.1007/s00270-013-0611-5

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  • DOI: https://doi.org/10.1007/s00270-013-0611-5

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