Abstract
This review will summarize the major efforts currently underway to develop osteoinductive bone graft substitutes for minimally invasive spine fusions. The primary categories of substitute include purified bone growth factors, recombinant bone growth factors, and growth factors delivered by gene therapy approaches. Clinical trials are underway for the purified and recombinant bone growth factors and pre-clinical studies have yielded promising results for a variety of gene therapy techniques for generating bone.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 4 August 1999 /Accepted: 26 August 1999
Rights and permissions
About this article
Cite this article
Ludwig, S., Kowalski, J. & Boden, S. Osteoinductive bone graft substitutes. E Spine J 9 (Suppl 1), S119–S125 (2000). https://doi.org/10.1007/PL00008317
Issue Date:
DOI: https://doi.org/10.1007/PL00008317