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Membrane-bound catechol-O-methyltransferase: A reevaluation of its role in the O-methylation of the catecholamine neurotransmitters

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Reviews of Physiology, Biochemistry and Pharmacology, Volume 120

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References

  • Aprille J, Malamud D (1975) Catechol-O-methyltransferase in mouse liver plasma membranes. Biochem Biophys Res Commun 64:1293–1302

    PubMed  Google Scholar 

  • Assicot M, Bohuon C (1969) Production of antibodies to catechol-O-methyltransferase (EC 2.1.1.6) of rat liver. Biochem Pharmacol 18:1893–1898

    Article  PubMed  Google Scholar 

  • Assicot M, Bohuon C (1970) Purification and studies of catechol-O-methyltransferase of rat liver. Eur J Biochem 12:490–495

    Article  PubMed  Google Scholar 

  • Assicot M, Bohuon C (1971) Presence of two distinct catechol-O-methyltransferase activities in red blood cells. Biochimie 53:871–874

    PubMed  Google Scholar 

  • Axelrod J, Tomchick R (1958) Enzymatic O-methylation of epinephrine and other catechols. J Biol Chem 233:702–705

    PubMed  Google Scholar 

  • Axelrod J, Senoh S, Witkop B (1958) O-methylation of catechol amines in vivo. J Biol Chem 233:697–701

    PubMed  Google Scholar 

  • Bertocci B, Miggiano V, da Prada M, Dembic Z, Lahm H, Malherbe P (1991) Human catechol-O-methyltransferase: cloning and expression of the membrane-bound form. Proc Natl Acad Sci USA 88:1416–1420

    PubMed  Google Scholar 

  • Bonisch H, Uhlig W, Trendelenburg U (1974) Analysis of the compartments involved in the extraneuronal storage and metabolism of isoprenaline in the perfused heart. Naunyn Schmiedebergs Arch Pharmacol 283:223–244

    Article  PubMed  Google Scholar 

  • Bonisch H, Graefe K-H, Trendelenburg U (1978) The determination of the rate constant for the efflux of an amine from efflux curves for amine and metabolite. Naunyn Schmiedebergs Arch Pharmacol 304:147–155

    Article  PubMed  Google Scholar 

  • Borchardt R, Cheng C (1978) Purification and characterization of rat heart and brain catechol methyltransferase. Biochim Biophys Acta 522:49–62

    PubMed  Google Scholar 

  • Borchardt R, Cheng C, Cooke P, Creveling C (1974) The purification and kinetic properties of liver microsomal-catechol-O-methyltransferase. Life Sci 14:1089–1100

    Article  PubMed  Google Scholar 

  • Branco D, Teixeira A, Azevedo I, Osswald W (1984) Structural and functional alteration caused at the extraneuronal level by sympathetic denervation of blood vessels. Nauny Schmiedebergs Arch Pharmacol 326:302–312

    Article  Google Scholar 

  • Broch O, Fonnum F (1972) The regional and subcellular distribution of catechol-O-methyltransferase in the rat brain. J Neurochem 19:2049–2055

    PubMed  Google Scholar 

  • Creveling C, Borchardt R, Isersky C (1973) Immunological characterization of catechol-O-methyltransferase. In: Usdin E, Snyder S (eds) Frontiers in catecholamine research. Pergamon New York, pp 117–119

    Google Scholar 

  • Fiebig ER, Trendelenburg U (1978) The kinetic constants for the extraneuronal uptake and metabolism of 3H-(−)-noradrenaline in the perfused rat heart. Naunyn Schmiedebergs Arch Pharmacol 303:37–45

    Article  PubMed  Google Scholar 

  • Francis A, Pearce LB, Roth JA (1985) Cellular localization of MAO A and B in brain: evidence from kainic acid lesions in striatum. Brain Res 334:59–64

    Article  PubMed  Google Scholar 

  • Francis A, Whittemore R, Jeffery D, Pearce L, Roth J (1987) Catecholamine-metabolizing enzyme activity in the nigrostriatal system. Biochem Pharmacol 36:2229–2231

    Article  PubMed  Google Scholar 

  • Garland LG, Martin GR (1984) Extraneuronal metabolism and supersensitivity to catecholamines in Guinea pig trachea. In: Fleming WW, Langer SZ, Graefe KH, Weiner N (eds) Neuronal and extraneuronal events in autonomic pharmacology. Raven, New York, pp 139–155

    Google Scholar 

  • Goldberg R, Tipton K (1978) The distribution of catechol-O-methyltransferase in pig liver and brain. Biochem Pharmacol 27:2623–2629

    Article  PubMed  Google Scholar 

  • Goldstein D, Weinshilboum R, Dunnette J, Creveling C (1980) Developmental patterns of catechol-O-methyltransferase in genetically different rat strains: enzymatic and immunochemical studies. J Neurochem 34:153–162

    PubMed  Google Scholar 

  • Graefe K-H, Trendelenburg U (1974) The effect of hydrocortisone on the sensitivity of the isolated nictitating membrane to catecholamines. Relationship to extraneuronal uptake and metabolism. Naunyn Schmiedebergs Arch Pharmacol 286:1–48

    Article  PubMed  Google Scholar 

  • Grohmann M (1987) The activity of the neuronal and extraneuronal catecholamine-metabolizing enzymes of the perfused rat heart. Naunyn Schmiedebergs Arch Pharmacol 336:139–147

    Article  PubMed  Google Scholar 

  • Grohmann M, Trendelenburg U (1985) The handling of five catecholamines by the extraneuronal O-methylating system of the rat heart. Naunyn Schmiedebergs Arch Pharmacol 329:264–270

    Article  PubMed  Google Scholar 

  • Grohmann M, Trendelenburg U (1988) The Handling of five amines by the extraneuronal deaminating system of the rat heart. Naunyn Schmiedebergs Arch Pharmacol 337:159–163

    PubMed  Google Scholar 

  • Grossman M, Creveling C, Rybczynski R, Braverman M, Isersky C, Breakefield X (1985) Soluble and particulate forms of rat catechol-O-methyltransferase distinguished by gel electrophoresis and immune fixation. J Neurochem 44:421–432

    PubMed  Google Scholar 

  • Guldberg HC, Marsden CA (1975) Catechol-O-methyltransferase: pharmacological aspects. Pharmacol Rev 27:135–206

    PubMed  Google Scholar 

  • Head RJ, Irvice RJ, Barone S, Stitzel RE, de la Lande IS (1985) Nonintracellular cell-associated O-methylation of isoproterinol in the isolated rabbit thoracic aorta. J Pharmacol Exp Ther 234:184–189

    PubMed  Google Scholar 

  • Henseling M (1983) Kinetic constants for uptake and metabolism of 3H-(−)-noradrenaline in rabbit aorta. Possible falsification of the constants by diffusion barriers within the vessel wall. Naunyn Schmiedebergs Arch Pharmacol 323:12–23

    Article  PubMed  Google Scholar 

  • Heydorn WE, Creed GJ, Creveling CR, Jacobowitz DM (1986) Molecular analysis of catechol-O-methyltransferase (COMT) in rat brain. Pharmacologist 28:232

    Google Scholar 

  • Huh M, Friedhoff A (1979) Multiple molecular forms of catechol-O-methyltransferase: evidence for two distinct forms, and their purification and physical characterization. J Biol Chem 254:299–308

    PubMed  Google Scholar 

  • Inscoe J, Daly J, Axelrod J (1965) Factors affecting the enzymatic formation of O-methylated dihydroxy derivatives. Biochem Pharmacol 14:1257–1263

    Article  PubMed  Google Scholar 

  • Jarrott B (1971) Occurrence and properties of catechol-O-methyltransferase in adrenergic neurons. J Neurochem 28:17–27

    Google Scholar 

  • Jarrott B (1973) The cellular localisation and physiological role of catechol-O-methyltransferase in the body. In: Usdin E, Snyder S (eds) Frontiers in catecholamine research. Pergamon, New York, pp 113–115

    Google Scholar 

  • Jarrott B, Iversen L (1971) Noradrenaline metabolizing enzymes in normal and sympathetically denervated vas deferens. J Neurochem 18:1–6

    PubMed  Google Scholar 

  • Jarrott B, Langer S (1971) Changes in monoamine oxidase and catechol-O-methyltransferase activities after denervation of the nictitating membrane of the cat. J Physiol (Lond) 212:549–559

    PubMed  Google Scholar 

  • Jeffery D, Roth J (1984) Characterization of membrane-bound and soluble catechol-O-methyltransferase from human frontal cortex. J Neurochem 42:826–832

    PubMed  Google Scholar 

  • Jeffery D, Roth J (1985) Purification and kinetic mechanism of human brain soluble catechol-O-methyltransferase. J Neurochem 44:881–885

    PubMed  Google Scholar 

  • Jeffery D, Roth J (1987) Kinetic reaction mechanism for magnesium binding to membrane-bound and soluble catechol-O-methyltransferase. Biochemistry 26:2955–2958

    Article  PubMed  Google Scholar 

  • Kaakkola S, Mannisto P, Nissinen E (1987) Striatal membrane-bound and soluble catechol-O-methyltransferase after selective neuronal lesions in the rat. J Neural Transm 69:221–228

    Article  PubMed  Google Scholar 

  • Kaplan G, Hartman B, Creveling C (1979) Immunohistochemical demonstration of catechol-O-methyltransferase in mammalian brain. Brain Res 167:241–250

    Article  PubMed  Google Scholar 

  • Kopin I (1986) Catecholamine metabolism: basic aspects and clinical significance. Pharmacol Rev 37:334–364

    Google Scholar 

  • Levitt P, Pintar J, Breakefield X (1982) Immunochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons. Proc Natl Acad Sci USA 79:6385–6389

    PubMed  Google Scholar 

  • Linden I, Nissinen E, Etemadzadeh E, Kaakkola S, Mannisto P, Pohto P (1988) Favorable effect of catechol-O-methyltransferase inhibition by OR-462 in experimental models of Parkinson's disease. J Pharmacol Exp Ther 247:289–293

    PubMed  Google Scholar 

  • Lundstrom K, Salminen M, Jalanko A, Savolainen R, Ulmanen I (1991) Cloning and characterization of human placental catechol-O-methyltransferase cDNA. DNA Cell Biol 10:181–189

    PubMed  Google Scholar 

  • Magaribuchi T, Hama T, Kurahashi K, Fujiwara M (1987) Effects of extraneuronal uptake inhibitors on the positive chronotropic response to isoprenaline and on the accumulation of isoprenaline in perfused rat heart after inhibition of catechol-O-methyltransferase. Naunyn Schmiedebergs Arch Pharmacol 335:123–128

    Article  PubMed  Google Scholar 

  • Major H, Sauerwein I, Graefe K (1978) Kinetics of the uptake and metabolism of 3H-(±) isoprenaline in the rat submaxillary gland. Naunyn Schmiedebergs Arch Pharmacol 305:51–63

    Article  PubMed  Google Scholar 

  • Mannisto P, Kaakkola S (1990) Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease. Pharmacol Toxicol 66:317–323

    PubMed  Google Scholar 

  • Mannisto P, Kaakkola S, Nissinen E, Linden I, Pohto P (1988) Properties of novel effective and highly selective inhibitors of catechol-O-methyltransferase. Life Sci 43:1465–1471

    Article  PubMed  Google Scholar 

  • Marsden C, Broch O, Guldberg H (1971) Catechol-O-methyltransferase and monoamine oxidase activities in rat submaxillary gland: effects of ligation, sympathectomy and some drugs. Eur J Pharmacol 15:335–342

    Article  PubMed  Google Scholar 

  • Marsden C, Broch O, Guldberg H (1972) Effect of nigral and raphe lesions on the catechol-O-methyltransferase and monoamine oxidase activities in the rat striatum. Eur J Pharmacol 19:35–42

    Article  PubMed  Google Scholar 

  • Marzullo G, Friedhoff A (1975) Catechol-O-methyltransferase from rat liver: two forms having different Meta: Para methylation ratios. Life Sci 17:933–942

    Article  Google Scholar 

  • McCormick J, Flanagan R, Lloyd A (1972) A microsomal catechol-O-methyltransferase from rat liver. Biochem J 130:83–84

    Google Scholar 

  • Nissinen E, Linden I, Schultz E, Kaakkola S, Mannisto P, Pohto P (1988) Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat. Eur J Pharmacol 153:263–269

    Article  PubMed  Google Scholar 

  • Paiva MA, Guimaraes S (1978) A comparative study of the uptake and metabolism of noradrenaline and adrenaline by the isolated saphenous vein of the dog. Naunyn Schmiedebergs Arch Pharmacol 303:221–228

    PubMed  Google Scholar 

  • Paiva MA, Guimaraes S (1984) The kinetic characteristics of the extraneuronal O-methylating system of the dog saphenous vein and the supersensitivity to catecholamines caused by its inhibition. Naunyn Schmiedebergs Arch Pharmacol 327:48–55

    Article  PubMed  Google Scholar 

  • Raxworthy M, Gulliver P, Hughes P (1982) The cellular location of catechol-O-methyltransferase in rat liver. Naunyn Schmiedebergs Arch Pharmacol 320:182–188

    Article  PubMed  Google Scholar 

  • Reid J, Stitzel R, Head R (1986) Characterization of the O-methylation of catechol oestrogens by intact rabbit thoracic aorta and subcellular fractions thereof. Naunyn Schmiedebergs Arch Pharmacol 334:17–28

    Article  PubMed  Google Scholar 

  • Rivett A, Eddy B, Roth J (1982) Contribution of sulfate conjugation, deamination, and O-methylation to metabolism of dopamine and norepinephrine in human brain. J Neurochem 39:1009–1016

    PubMed  Google Scholar 

  • Rivett A, Francis A, Roth J (1983a) Distinct cellular localization of membrane-bound and soluble forms of catechol-O-methyltransferase in brain. J Neurochem 40:215–219

    PubMed  Google Scholar 

  • Rivett A, Francis A, Roth J (1983b) Localization of membrane-bound catechol-O-methyltransferase. J Neurochem 40:1494–1496

    PubMed  Google Scholar 

  • Roffman M, Reigle T, Orsulak P, Schildkraut J (1976) Properties of catechol-O-methyltransferase in soluble and particulate preparations from rat red blood cells. Biochem Pharmacol 25:208–209

    Article  PubMed  Google Scholar 

  • Roth JA, Rivett AJ, Renskers KJ (1982) Properties of human brain phenolsulfotransferase and its role in the inactivatio of catecholamine neurotransmitters. In: Mulder G, Caldwell J, van Kempen G, Vonk R (eds) Sulfate metabolism and sulfate conjugation. Taylor and Francis, London, pp 107–114

    Google Scholar 

  • Roth J, Grossman M, Adolf M (1990) Variation in hepatic membrane-bound catechol-O-methyltransferase activity in Fischer and Wistar-Furth strains of rat. Biochem Pharmacol 40:1151–1153

    Article  PubMed  Google Scholar 

  • Salminen M, Lundstrom K, Tilgmann C, Savolaimen R, Kilkkinen N, Ulmanen I (1990) Molecular cloning and characterization of rat liver catechol-O-methyltransferase. Gene 93:241–247

    Article  PubMed  Google Scholar 

  • Schultz E, Nissinen E (1989) Inhibition of rat liver and duodenum soluble catechol-O-methyltransferase by a tight-binding inhibitor OR-462. Biochem Pharmacol 38:3953–3956

    Article  PubMed  Google Scholar 

  • Sladek-Chelgren S, Weinshilboum R (1981) Catechol-O-methyltransferase biochemical genetics: human lymphocyte enzyme. Biochem Genet 19:1037–1053

    Article  PubMed  Google Scholar 

  • Tilgmann C, Kalkkinen N (1990) Purification and partial characterization of rat liver soluble catechol-O-methyltransferase. FEBS Lett 264:95–99

    Article  PubMed  Google Scholar 

  • Tong J, d'Iorio A (1977) Solubilization and partial purification of particulate catechol-O-methyltransferase from rat liver. Can J Biochem 55:1108–1113

    PubMed  Google Scholar 

  • Traiger G, Calvert D (1969) O-methylation of 3H-norepinephrine by epididymal adipose tissue. Biochem Pharmacol 18:109–117

    Article  PubMed  Google Scholar 

  • Trendelenburg U (1980) A kinetic analysis of the extraneuronal uptake and metabolism of catecholamines. Rev Physiol Biochem Pharmacol 87:35–115

    Google Scholar 

  • Trendelenburg U (1984a) Metabolizing systems. In: Fleming W, Langer S, Graefe K, Weiner N (eds) Neuronal and extraneuronal events in autonomic pharmacology. Raven, New York, pp 93–109

    Google Scholar 

  • Trendelenburg U (1984b) The influence of inhibition of catechol-O-methyltransferase or of monoamine oxidase on the extraneuronal metabolism of 3H-(-)-noradrenaline in the rat heart. Naunyn Schmiedebergs Arch Pharmacol 327:285–292

    Article  PubMed  Google Scholar 

  • Trendelenburg U (1988) The extraneuronal uptake and metabolism of catecholamines. In: Trendelenburg U, Weiner (eds) Handbook of experimental pharmacology, vol 90/1. Springer, Berlin Heidelberg New York, pp 279–319

    Google Scholar 

  • Trendelenburg U, Hohn D, Graefe K, Pluchino S (1971) The influence of block of catechol-O-methyltransferase on the sensitivity of isolated organs to catecholamines. Naunyn Schmiedebergs Arch Pharmacol 271:59–92

    Article  PubMed  Google Scholar 

  • Verity M, Su C, Bevan J (1972) Transmural and subcellular localization of monoamine oxidase and catechol-O-methyltransferase in rabbit aorta. Biochem Pharmacol 21:193–201

    Article  PubMed  Google Scholar 

  • Weinshilboum R (1989) Methyltransferase pharmacogenetics. Pharmacol Ther 43:77–90

    Article  PubMed  Google Scholar 

  • Weinshilboum R, Raymond F (1976) Calcium inhibition of rat liver catechol-O-methyltransferase. Biochem Pharmacol 25:573–579

    Article  PubMed  Google Scholar 

  • Weinshilboum R, Raymond F (1977a) Inheritance of low catechol-O-methyltransferase activity in man. Am J Hum Genet 29:125–135

    PubMed  Google Scholar 

  • Weinshilboum R, Raymond F (1977b) Variations in catechol-O-methyltransferase activity in inbred strains of rats. Neuropharmacology 16:703–706

    Article  PubMed  Google Scholar 

  • Weinshilboum R, Raymond F, Frohnauer M (1978) Monogenic inheritance of catechol-O-methyltransferase activity in the Rat — biochemical and genetic studies. Biochem Pharmacol 28:1239–1247

    Article  Google Scholar 

  • Zou J, Pentney R, Roth J (1990) Immunohistochemical detection of phenol sulfotransferase containing neurons in human brain. J Neurochem 55:1154–1158

    PubMed  Google Scholar 

  • Zurcher G, Keller HH, Borgulya J, da Prada M (1989) Neuropharmacological effects in rats of the new reversible COMT inhibitors Ro 40-7592 and Ro 41-0960. J Neurochem 52:S16

    Google Scholar 

  • Zurcher G, Keller HH, Kettler R, Borgulya J, Bonetti EP, da Prada M (1990) Ro-40-7592, a novel, very potent and orally active inhibitor of catechol-O-methyltransferase — a pharmacological study in rats. Parkinsons Disease: Anatomy, Pathology and Therapy 53:497–503

    Google Scholar 

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  1. Department of Pharmacology and Therapeutics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, 14214, Buffalo, New York, USA

    Jerome A. Roth

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Roth, J.A. (1992). Membrane-bound catechol-O-methyltransferase: A reevaluation of its role in the O-methylation of the catecholamine neurotransmitters. In: Reviews of Physiology, Biochemistry and Pharmacology, Volume 120. Reviews of Physiology, Biochemistry and Pharmacology, vol 120. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0036121

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