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Effects of Fluprazine Hydrochloride on Reactivity to a Nonconspecific Intruder

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Abstract

Treatment with 8.0 mg/kg of fluprazine hydrochloride completely suppressed defensive burying of albino mice directed toward an intruding tiger salamander. This treatment also increased mouse-salamander social distances. The results are consistent with earlier data in suggesting that fluprazine potentiates tearfulness and indicate that this effect extends to nonconspecific intruders as well as novel inanimate stimuli, shock, and conspecifics. This rather generalized drug-induced tearfulness may contribute heavily to fluprazine’s potent inhibition of offense, maternal behavior, play, and predation.

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Authors and Affiliations

  1. Division of Social Sciences, University of Minnesota-Morris, Morris, MN, 56267, USA

    Leslie R. Meek, Brett M. Gibson & Ernest D. Kemble

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  1. Leslie R. Meek
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  2. Brett M. Gibson
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  3. Ernest D. Kemble
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Meek, L.R., Gibson, B.M. & Kemble, E.D. Effects of Fluprazine Hydrochloride on Reactivity to a Nonconspecific Intruder. Psychol Rec 39, 203–210 (1989). https://doi.org/10.1007/BF03395063

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  • DOI: https://doi.org/10.1007/BF03395063

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