Abstract
A case of a very rare combination of diffuse sclerosing variant of papillary thyroid carcinoma (DSPC) and primary squamous thyroid carcinoma (PSC) is presented. A 25-yr-old woman with right-sided neck mass and hypothyroidism was admitted. US showed that the right lobe of the thyroid gland was enlarged with irregular margins and heterogen echogenity and there were multiple small punctate echogenic foci in the central portion. A scintigraphy with 99mTc showed decreased uptake in the right lobe. FNA of the right lobe induced us to consider the presence of follicular neoplasm. Chest roentgenogram was normal. Total thyroidectomy with right-sided modified radical neck dissection was performed. Findings related to Hashimoto’s thyroiditis and abundant psammoma bodies were observed in the frozen sections. Histopathologic findings demonstrated the coexistence of DSPC and PSC in both lobes and 16 lymph nodes metastases and soft tissue infiltration. Radioiodine was administered to ablate residual thyroid tissue. She was given T4 suppression therapy. At the 44th month of follow-up, she remains well without recurrences and metastases. The coexistence of DSPC and thyroiditis or PSC is still under debate. Very few cases with the combination of papillary thyroid carcinoma and PSC have been reported previously, thus we discuss the clinico-pathologic features and possible explanation for this unusual coexistence of malignancies.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Hefer T., Joachims H.Z., Eitan A., Munichor M. Are the morphology of papillary thyroid carcinoma and the tumour’s behaviour correlated? J. Laryngol. Otol. 1996, 110: 704–705.
Damiani S., Dina R., Eusebi V. Cytologic grading of aggressive and nonaggressive variants of papillary thyroid carcinoma. Am. J. Clin. Pathol. 1994, 101: 651–655.
Vickery A.L., Carcangiu M.L., Johannessen J.V. Papillary carcinoma. Session I of thyroid tumor pathology. Semin. Diagn. Pathol. 1985, 2: 90–100.
Soares J., Limbert E., Sobrinho-Simoes M. Diffuse sclerosing variant of papillary thyroid carcinoma. A clinicopathologic study of 10 cases. Path. Res. Pract.1989, 185: 200–206.
Burman K.D., Ringel M.D., Wartofsky L. Unusual types of thyroid neoplasms. Squamous cell carcinoma. Endocrinol. Metab. Clin. North Am. 1996, 25: 56–59.
Carcangiu M.L., Bianchi S. Diffuse sclerosing variant of papillary thyroid carcinoma. Clinicopathologic study of 15 cases. Am. J. Surg. Pathol. 1989, 13: 1041–1049.
Livolsi V.A. Pathology of thyroid disease. In: Braverman L.E., Utiger R.D. (Eds.), Werner & Ingbar’s Thyroid: A fundamental and clinical text, ed. 8. Lippincott Williams & Wilkins, Philadelphia, 2000, p. 497.
Thyroid gland. In: Rosai J. (Ed.), Ackerman’s Surgical Pathology, ed. 8. Mosby-Year Book, Inc., St. Louis, 1996, vol. 1, p. 522.
Carcangiu M.L., De Lellis R.A. Thyroid gland. In: Damjanov I., Linder J. (Eds.), Anderson’s Pathology, ed. 10. Mosby-Year Book, Inc., St. Louis, 1996, vol. 2, p. 1961.
Leung C., Hartwick R.W.J., Bedard Y.C. Correlation of cytologic and histologic features in variants of papillary carcinoma of the thyroid. Acta Cytol. 1993, 37: 645–650.
Kumar P., Malekhusseini S., Talei A. Primary squamous cell carcinoma of the thyroid diagnosed by fine needle aspiration cytology. A report of two cases. Acta Cytol. 1999, 43: 659–662.
Kleer C., Giordano T., Merino M. Squamous cell carcinoma of the thyroid: an aggressive tumor associated with tall cell variant of papillary thyroid carcinoma. Mod. Pathol. 2000, 13: 742–746.
Albareda M., Puig-Domingo M., Wengrowicz S. Clinical forms of presentation and evaluation of diffuse sclerosing variant of papillary carcinoma and insular variant of follicular carcinoma of the thyroid. Thyroid 1998, 8: 385–391.
Hayashi Y., Sasao T., Takeichi N. Diffuse sclerosing variant of papillary carcinoma of the thyroid. A histopathological study of four cases. Acta Pathol. Jpn. 1990, 40: 193–198.
Sagan C., Fiche M., Cuilliere P., Leborgne J. Carcinome papillaire sclerosant diffus de la thyroide. Presentation d’un cas. Ann. Pathol. 1993, 13: 256–259.
Moreno Egea A., Rodriguez Gonzalez J.M., Sola Perez J., Soria T., Parrilla Paricio P. Clinicopathological study of the diffuse sclerosing variety of papillary cancer of the thyroid. Presentation of 4 new cases and review of the literature. Eur. J. Surg. Oncol. 1994, 20: 7–11.
Schröder S., Bay V., Dumke K. Diffuse sclerosing variant of papillary thyroid carcinoma. S-100 protein immunochemistry and prognosis. A case report. Virchows Arch. 1990, 416: 367–371.
Harada T., Shimaoka K., Yakumaru K. Squamous cell carcinoma of the thyroid gland-transition from adenocarcinoma. J. Surg. Oncol. 1982, 19: 36–43.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kebapci, N., Efe, B., Kabukcuoglu, S. et al. Diffuse sclerosing variant of papillary thyroid carcinoma with primary squamous cell carcinoma. J Endocrinol Invest 25, 730–734 (2002). https://doi.org/10.1007/BF03345109
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03345109