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Pineal gland and aging

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References

  1. Sladek J.R., Schöler J., Armstrong W.E.: Norepinephrine-vasopressin interactions during aging. In: Sano Y. (Ed.), Structure and function of peptidergic and aminergic neurons. Japan Sci. Soc. Press, Tokyo, 1983, pp. 289–298.

  2. Gottfries C.G.: Monoamines and myelin components in aging and dementia disorders. In: Swaab D.F., Fliers E., Mirmiran M., Van Gool W.A., VanHaaren F. (Eds.), Progress in brain research, Vol. 70.Elsevier Sci. Publ., Amsterdam, New York, Oxford, 1986, pp. 133–140.

    Google Scholar 

  3. Fliers E., Swaab D.F.: Neuropeptide changes in aging and Alzheimer’s disease. In: Swaab D.F., Fliers E., Mirmiran M., Van Gool W.A., Van Haaren F. (Eds.), Progress in brain research, Vol. 70.Elsevier Sci. Publ., Amsterdam, New York, Oxford, 1986, pp. 141–152.

    Google Scholar 

  4. Rusak B., Zucker I.: Neural regulation of circadian rhythms. Physiol. Rev. 59: 449–526, 1979.

    PubMed  CAS  Google Scholar 

  5. Ingram D.K., London E.D., Reynolds M.A.: Circadian rhythmicity and sleep: effects of aging in laboratory animals. Neurobiol. Aging 3: 287–297, 1982.

    Article  PubMed  CAS  Google Scholar 

  6. Van Gool W.A., Mirmiran M.: Aging and circadian rhythms. In: Swaab D.F., Fliers E., Mirmiran M., Van Gool W.A., Van Haaren F. (Eds.), Progress in brain research, Vol. 70. Elsevier Sci. Publ., Amsterdam, New York, Oxford, 1986, pp. 255–277.

    Google Scholar 

  7. Samis H.V. jr.: Aging: loss of temporal organization. Perspect. Biol. Med. 3: 95–102, 1968.

    Google Scholar 

  8. Pittendrigh C.S., Daan S.: Circadian oscillations in rodents: a systematic increase of their frequency with age. Science 186: 548–550, 1974.

    Article  PubMed  CAS  Google Scholar 

  9. Swaab D.F., Fliers E., Partiman T.S.: The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia. Brain Res. 342: 37–44, 1985.

    Article  PubMed  CAS  Google Scholar 

  10. Pickard G.E., Turek F.W.: The suprachiasmatic nuclei: two circadian clocks? Brain Res. 268: 201–210, 1983.

    Article  PubMed  CAS  Google Scholar 

  11. Hoffmann K., Illnerová H., Vaněček J.: Effect of photoperiod and of one minute light at night-time on the pineal rhythm in N-acetyltransferase activity in the Djungarian hamster Phodopus sungorus. Biol Reprod. 24: 551–556, 1981.

    Article  PubMed  CAS  Google Scholar 

  12. Carter D.S., Goldman B.D.: Antigonadal effects of timed melatonin infusion in pinealectomized male Djungarian hamsters (Phodopus sungorus sungorus): duration is the critical parameter. Endocrinology 113: 1261–1267, 1983.

    Article  PubMed  CAS  Google Scholar 

  13. Wildi R., Frauchiger E.: Modifications histologiques de l’épiphyse humaine pendant l’enfance, l’age adulte et le vieillissement. Prog. Brain Res. 10: 218–223, 1965.

    Article  PubMed  CAS  Google Scholar 

  14. Tapp E., Huxley M.: The histological appearance of the human pineal gland from puberty to old age. J. Pathol. Bacteriol. 108: 137–144, 1972.

    Article  CAS  Google Scholar 

  15. Vollrath L.: The pineal organ. In: Oksche A., Vollrath L. (Eds.), Handbuch der mikroskopischen Anatomie des Menschen, Vol. VI/7. Springer, Berlin, 1981.

    Google Scholar 

  16. Galliani I., Frank F., Gobbi P., Giangaspero F., Falcieri E.: Histochemical and ultrastructural study of the human pineal gland in the course of aging. J. Submicrosc. Cytol. 21: 571–578, 1989.

    CAS  Google Scholar 

  17. Lukaszyk A., Reiter R.J.: Histophysiological evidence for the secretion of polypeptides by the pineal gland. Am. J. Anat. 143: 451–464, 1975.

    Article  PubMed  CAS  Google Scholar 

  18. Welsh M.G.: Pineal calcification: structural and functional aspects. In: Reiter R.J. (Ed.), Pineal research review, Vol. 3.Alan R. Liss Inc., New York, 1985, pp. 41–68.

    Google Scholar 

  19. Trentini G.P., De Gaetani C.F., Pierini G., Criscuolo M., Vidyasagar R.J., Fabbri F.: Some aspects of human pineal pathology. In: Reiter R.J., Karasek M. (Eds.), Advances in pineal research: 1.John Libbey, London-Paris, 1986, pp. 219–229.

    Google Scholar 

  20. Trentini G.P., De Gaetani CF., Criscuolo M., Migaldi M., Ferrari G.: Pineal calcification in different physiopathological conditions in humans. In: Trentini G.P., De Gaetani CF., Pévet P. (Eds.), Fundamentals and clinics in pineal research. Raven Press, New York, 1987, pp. 291–304.

    Google Scholar 

  21. Reiter R.J., Richardson B.A., Johnson L.Y., Ferguson B.N., Dinh D.I.: Pineal melatonin rhythm: reduction in aging Syrian hamsters. Science 210: 1372–1373, 1980.

    Article  PubMed  CAS  Google Scholar 

  22. Touitou Y., Fèvre-Montange M., Proust J., Klinger E., Nakache J.P.: Age and sex-associated modification of plasma melatonin concentrations in man. Relationship to pathology, malignant or not, and autopsy findings. Acta Endocrinol. (Copenh.) 108: 135–144, 1985.

    CAS  Google Scholar 

  23. Reiter R.J., Craft M.C, Johnson J.E., King T.S., Richardson B.A., Vaughan G.M., Vaughan M.K.: Age-associated reduction in nocturnal melatonin levels in female rats. Endocrinology 109: 1295–1297, 1981.

    Article  PubMed  CAS  Google Scholar 

  24. Touitou Y., Fèvre M., Lagoguey M., Carayon A., Bogdan A., Reinberg A., Beck H., Cesselin F., Touitou C: Age and mental health-related circadian rhythms of plasma levels of melatonin, prolactin, luteinizing hormone and follicle stimulating hormone in man. J. Endocrinol. 91: 467–475, 1981.

    Article  PubMed  CAS  Google Scholar 

  25. Reiter R.J., Vriend J., Brainard G.C., Matthews S.A., Craft C.M.: Reduced pineal and plasma melatonin levels and gonadal atrophy in old hamsters kept under winter photoperiod. Exp. Aging Res. 8: 27–30, 1982.

    Article  CAS  Google Scholar 

  26. Iguchi H., Kato K.-I., Ibayashi H.: Age-dependent reduction in serum melatonin concentrations in healthy human subjects. J. Clin. Endocrinol Metab. 55: 27–29, 1982.

    Article  CAS  Google Scholar 

  27. Pang S.F., Tang P.L.: Decreased serum and pineal concentrations of melatonin and N-acetylserotonin in aged male hamsters. Horm. Res. 17: 228–234, 1983.

    Article  PubMed  CAS  Google Scholar 

  28. Pang S.F., Tang F., Tang P.L.: Negative correlation of age and the results of pineal melatonin, pineal Nacetylserotonin and serum melatonin in male rats. J. Exp. Zool. 229: 41–47, 1984.

    Article  PubMed  CAS  Google Scholar 

  29. Tang F., Hadjiconstantinou M., Pang S.F.: Aging and diurnal rhythms of pineal serotonin, 5-hydroxyindoleacetic acid, norepinephrine, dopamine and serum melatonin in the male rat. Neuroendocrinology 40: 160–164, 1985.

    Article  PubMed  CAS  Google Scholar 

  30. Reuss S., Olcese J., Vollrath L.: Electrophysiological and endocrinological aspects of aging in the rat pineal gland. Neuroendocrinology 43: 466–470, 1986.

    Article  PubMed  CAS  Google Scholar 

  31. Friedman E., Cooper T., Yocca F.: The effect of imipramine treatment on brain serotonin receptors and β-adrenoceptors and on pineal β-adrenergic function in adult and aged rats. Eur. J. Pharmacol. 123: 351–356, 1986.

    Article  PubMed  CAS  Google Scholar 

  32. Nair N.P.V., Hariharasubramanian N., Pilapil C, Isaac I., Thavundajil J.X.: Plasma melatonin — an index of brain aging in humans? Biol. Psychiatry 21: 141–150, 1986.

    CAS  Google Scholar 

  33. Brown G.M., Young S.N., Gauthier S., Tsui H., Grota L.J.: Melatonin in human cerebrospinal fluid in daytime: its origin and variation with age. Life Sci. 25: 929–936, 1979.

    Article  PubMed  CAS  Google Scholar 

  34. Sack R.L., Lewy A.J., Erb D.L., Vollmer W.M., Singer C.M.: Human melatonin production decreases with age. J. Pineal Res. 3: 379–388, 1986.

    Article  PubMed  CAS  Google Scholar 

  35. Markey S.P., Higa S., Shih M., Danforth D.N., Tamarkin L.: The correlation between human plasma melatonin levels and urinary 6-hydroxymelatonin excretion. Clin. Chim. Acta 150: 221–225, 1985.

    Article  PubMed  CAS  Google Scholar 

  36. Tetsuo M., Markey S.P., Kopin I.J.: Measurement of 6-hydroxymelatonin in human urine and its diurnal variations. Life Sci. 27: 105–109, 1980.

    Article  PubMed  CAS  Google Scholar 

  37. Tetsuo M., Perlow M.J., Mishkin M., Markey S.P.: Light exposure reduces and pinealectomy virtually stops urinary excretion of 6-hydroxymelatonin by Rhesus monkeys. Endocrinology 110: 997–1003, 1982.

    Article  PubMed  CAS  Google Scholar 

  38. Tang P.L., Hong G.X., Yau M.Y.C., Pang S.F.: Alterations in circulating melatonin levels in male rats with growth and aging. In: Reiter R.J., Pang S.F. (Eds.), Advances in pineal research: 3.John Libbey, London-Paris, 1989, pp. 133–136.

    Google Scholar 

  39. Dax E.M., Sugden D.: Age-associated changes in pineal adrenergic receptors and melatonin synthesizing enzymes in the Wistar rat. J. Neurochem. 50: 468–472, 1988.

    Article  PubMed  CAS  Google Scholar 

  40. Wurtman R.J., Axelrod J., Barchas J.D.: Age and enzyme activity in the human pineal. J. Clin. Endocrinol. Metab. 24: 299–301, 1964.

    Article  PubMed  CAS  Google Scholar 

  41. Quay W.B.: Pineal chemistry. Thomas, Springfield, 1974.

    Google Scholar 

  42. Walker R.F., McMahon K.M., Pivorun E.B.: Pineal gland structure and respiration as affected by age and hypocaloric diet. Exp. Gerontol. 13: 91–99, 1978.

    Article  PubMed  CAS  Google Scholar 

  43. Olpe H.-R., Steinmann M.W.: Age-related decline in the activity of noradrenergic neurons of the rat locus coeruleus. Brain Res. 251: 174–176, 1982.

    Article  PubMed  CAS  Google Scholar 

  44. Greenberg L.H., Weiss B.: Neural and hormonal modulation of adrenergic receptors in aging. In: Greenberg L.H., Weiss B. (Eds.), Altered endocrine status during aging. Alan R. Liss Inc., New York, 1984, pp. 57–70.

    Google Scholar 

  45. Greenberg L.H., Weiss B.: β-adrenergic receptors in aged rat brain: reduced number and capacity of pineal gland to develop supersensitivity. Science 201: 61–63, 1978.

    Article  PubMed  CAS  Google Scholar 

  46. Pulido O., Clifford J.: Age-associated changes in the circadian rhythm of retinal N-acetylserotonin and melatonin in rats with pigmented eyes. Exp. Gerontol 21: 23–30, 1986.

    Article  PubMed  CAS  Google Scholar 

  47. Besharse J., Dunis D.A.: Methoxyindoles and photoreceptor metabolism: activation of rod shedding. Science 219: 1341–1343, 1983.

    Article  PubMed  CAS  Google Scholar 

  48. Bubenik G.A., Purtill R.A.: The role of melatonin and dopamine in retinal physiology. Can. J. Physiol Pharmacol 58: 1457–1462, 1980.

    Article  PubMed  CAS  Google Scholar 

  49. Steinlechner S.: Is there a feedback loop between the pineal gland and the retina? In: Reiter R.J., Pang S.F. (Eds.), Advances in pineal research: 3.John Libbey, London-Paris, 1989, pp. 175–180.

    Google Scholar 

  50. Niles L.P., Pulido O.: Age-related changes in N-acetylindoleamine and GABA binding in rat brain. In: Gupta D., Reiter R.J. (Eds.), The pineal gland during development: from fetus to adult. Croom Helm, London-Sydney, 1986, pp. 268–274.

    Google Scholar 

  51. Zisapel N., Laudon M., Nir I.: Melatonin receptors in discrete brain regions of the male rats: age-associated decrease in receptor density and in circadian rhythmicity. In: Reiter R.J., Pang S.F. (Eds.), Advances in pineal research: 3.John Libbey, London-Paris, 1989, pp. 189–194.

    Google Scholar 

  52. Aschheim P.: Relation of neuroendocrine system to reproductive decline in female rats. In: Meites J. (Ed.), Neuroendocrinology of aging. Plenum Press, New York, 1983, pp. 61–72.

    Google Scholar 

  53. Peng M.T.: Changes in hormone uptake and receptors in the hypothalamus during aging. In: Meites J. (Ed.), Neuroendocrinology of aging. Plenum Press, New York, 1983, pp. 73–84.

    Google Scholar 

  54. Walker R.F.: Animal models for aging of the reproductive system. In: Walker R.F., Cooper R.L. (Eds.), Experimental and clinical interventions in aging. Marcel Dekker, New York, 1983, pp. 67–84.

    Google Scholar 

  55. Urban R.J., Veldhuis J.D.: Hypothalamo-pituitary concomitants of aging. In: Sowers J.R., Felicetta J.V. (Eds.), The endocrinology of aging. Raven Press, New York, 1988, pp. 41–74.

    Google Scholar 

  56. Harman S.M., Talbert G.B.: In: Finch C.E., Schneider E.L. (Eds.), Handbook of the biology of aging, ed. 2.Van Nostrand Reinhold Co., New York, 1985, pp. 457–510.

  57. Lightman S.L., Jacobs H.S., Maguire A.K., Mc Garrick G., Jeffcoate S.L.: Climateric flushing: clinical and endocrine response to infusion of naloxone. Br. J. Obstet Gynaecol. 88: 919–924, 1981.

    Article  PubMed  CAS  Google Scholar 

  58. Albertazzi E., Barbanti Silva C, Trentini G.P., Botticelli A.R.: Influence de l’épiphysectomie et du traitement avec la 5-hydroxytryptamine sur le cycle oestral de la ratte albinos. Ann. Endocrinol. 27: 93–100, 1966.

    Google Scholar 

  59. Trentini G.P., Mess B., De Gaetani CF., Rúzsás C.: Effect of melatonin on induction of ovulation in the light induced constant estrous-anovulatory syndrome and possible role of the brain serotoninergic system. J. Endocrinol. Invest. 1: 305–310, 1978.

    PubMed  CAS  Google Scholar 

  60. Trentini G.P., Mess B., De Gaetani C.F., Rúzsás C, De Benedittis A: Role of serotonergic mechanisms in modulating effects of melatonin upon reproductive activity in the rat. In: Mess B., Rúzsás C., Tima L, Pévet P. (Eds.), The pineal gland: current state of pineal research. Akadémiai Kiado, Budapest, 1985, pp. 231–251.

    Google Scholar 

  61. Trentini G.P., Rúzsás C., Criscuolo M., Zarcone N.A.: The role of serotonergic and non-serotonergic mechanisms as modulators of the pineal influence on reproduction. In: Gupta D., Reiter R.J. (Eds.), The pineal gland during development: from fetus to adult. Croom Helm, London-Sydney, 1986, pp. 195–208.

    Google Scholar 

  62. Trentini G.P., De Gaetani CF., Criscuolo M., Zarcone N.A.: Melatonin and reproduction. In: Genazzani A.R., Volpe A., Facchinetti F. (Eds.), Gynecological endocrinology. Parthenon Publ., Carnforth, 1987, pp. 55–63.

    Google Scholar 

  63. Quay W.B.: Changes with darkness in regional brain 5-hydroxytryptamine and 5-hydroxyindole acetic acid: local differences with pinealectomy, sham surgery, and melatonin. Neurochem. Res. 14: 957–961, 1989.

    Article  PubMed  CAS  Google Scholar 

  64. Timiras P.S., Hudson D.B.: Changes in neurohumoral transmission during aging of the central nervous system. In: Adelman R.C., Roberts J., Baker G.T. III, Baskin S.I., Cristofalo V.J. (Eds.), Neural regulatory mechanisms during aging. Alan R. Liss Inc., New York, 1980, pp. 25–34.

    Google Scholar 

  65. Simpkins J.W., Mueller G.P., Huang H.H., Meites J.: Evidence for depressed catecholamine and enhanced serotonin metabolism in aging male rats: possible relation to gonadotropin secretion. Endocrinology 100: 1672–1678, 1977.

    Article  PubMed  CAS  Google Scholar 

  66. Huang H.H., Simpkins J., Meites J.: Hypothalamic norepinephrine and dopamine turnover in ovariectomized old rats treated with gonadal steroids. Physiologist 22: 71, 1979.

    Google Scholar 

  67. Meites J.: Change in neuroendocrine control of anterior pituitary function during aging. Neuroendocrinology 34: 151–156, 1982.

    Article  PubMed  CAS  Google Scholar 

  68. Forman L.J., Sonntag W.E., Miki N., Meites J.: Maintenance by L-dopa treatment of estrous cycles and LH response to estrogen in aging female rats. Exp. Aging Res. 6: 547–554, 1980.

    Article  PubMed  CAS  Google Scholar 

  69. Walker R.F.: Relationship of the raphe and suprachiasmatic nuclei to serotonin facilitation of cyclic reproductive functions in aging female rats. In: Scheff S.W. (Ed.), Aging and recovery of function. Plenum Press, New York, 1984, pp. 87–99.

    Chapter  Google Scholar 

  70. De Gaetani CF., Criscuolo M., Ferrari G., Genazzani A.R., Trentini G.P.: Pineal gland and rat reproductive function. In: Genazzani A.R., Montemagno U., Nappi C., Petraglia F. (Eds.), The brain and female reproductive function. Parthenon Publ., Carnforth, 1988, pp. 257–262.

    Google Scholar 

  71. Steger R.W., Sonntag W.E., Van Vugt D.A., Forman L.J., Meites J.: Reduced ability of naloxone to stimulate LH and testosterone release in aging male rats: possible relation to increase in hypothalamic met-5-enkephalin. Life Sci. 27: 747–753, 1980.

    Article  PubMed  CAS  Google Scholar 

  72. Coiro V., Passed M., Volpi R., Marchesi M., Bertoni M., Fagnoni F., Schianchi L., Bianconi L., Marcato A., Chiodera P.: Different effects of aging on the opioid mechanisms controlling gonadotropin and cortisol secretion in man. Horm. Res. 32: 119–123, 1989.

    Article  PubMed  CAS  Google Scholar 

  73. Marchetti B., Cioni M.: Opposite changes of pituitary and ovarian receptors for LHRH in aging rats: further evidence for a direct neural control of ovarian LHRH receptor activity. Neuroendocrinology 48: 242–251, 1987.

    Article  Google Scholar 

  74. Agnati L.F., Fuxe K., Zoli M., Ozini I., Toffano G., Ferraguti F.: A correlation analysis of the regional distribution of central enkephalin and β-endorphin immunoreactive terminals and of opiate receptors in adult and old male rats. Evidence for the existence of two main types of communication in the central nervous system: the volume transmission and the wiring transmission. Acta Physiol. Scand. 128: 201–207, 1986.

    CAS  Google Scholar 

  75. Herz A.: Multiple opiate receptors and their functional significance. J. Neural Transm. (Suppl. 18): 227-233, 1983.

    Google Scholar 

  76. Hollt V.: Opioid peptide processing and receptor selectivity. Ann. Rev. Pharmacol. Toxicol. 26: 59–77, 1986.

    Article  CAS  Google Scholar 

  77. Ferin M., Van Vugt D., Wardlaw S.: The hypothalamic control of the menstrual cycle and the role of endogenous opioid peptides. Recent Prog. Horm. Res. 40: 441–485, 1984.

    PubMed  CAS  Google Scholar 

  78. Malven P.V.: Inhibition of pituitary LH release resulting from endogenous opioid peptides. Domestic Anim. Endocrinol 3: 135–144, 1986.

    Article  CAS  Google Scholar 

  79. Leadum C.A., Yagenova S.V.: Effects of specific activation of mu-, delta- and kappa-opioid receptors on the secretion of luteinizing hormone and prolactin in ovariectomized rat. Neuroendocrinology 45: 109–117, 1987.

    Article  Google Scholar 

  80. Haskins J.T., Gudelsky G.A., Moss R.L., Porter J.C.: Iontophoresis of morphine into the arcuate nucleus: effects on dopamine concentrations in hypophysial portal plasma and serum prolactin concentrations. Endocrinology 108: 767–771, 1981.

    Article  PubMed  CAS  Google Scholar 

  81. Reymond M.J., Kaur C., Porter J.C.: An inhibitory role for morphine on the release of dopamine into hypophysial portal blood and on the synthesis of dopamine in tuberoinfundibular neurons. Brain Res. 262: 253–258, 1983.

    Article  PubMed  CAS  Google Scholar 

  82. Van Vugt D.A., Sylvester P.W., Aylsworth C.F., Meites J.: Counteraction of gonadal steroid inhibition of luteinizing hormone release by naloxone. Neuroendocrinology 34: 274–278, 1982.

    Article  PubMed  Google Scholar 

  83. Blank M.S., Roberts D.L.: Antagonist of gonadotropin-releasing. hormone blocks naloxone-induced elevations in serum luteinizing hormone. Neuroendocrinology 35: 309–312, 1982.

    CAS  Google Scholar 

  84. Harsing L.G. jr., Yang H.-Y.T., Costa E.: Accumulation of hypothalamic endorphins after repeated injections of anorectics which release serotonin. J. Pharmacol. Exp. Ther. 223: 689–694, 1982.

    PubMed  CAS  Google Scholar 

  85. Harsing L.G. jr., Yang H.-Y.T., Govoni S., Costa E.: Elevation of met 5-enkephalin and β-endorphin hypothalamic content in rats receiving anorectic drugs: Differences between d-fenfluramine and d-amphetamine. Neuropharmacology 21: 141–145, 1982.

    Article  PubMed  Google Scholar 

  86. Lakin M., Miller C.H., Scott M.L., Winter W.D.: Involvement of the pineal gland and melatonin in murine analgesia. Life Sci. 29: 2543–2551, 1981.

    Article  PubMed  CAS  Google Scholar 

  87. Kavaliers M.: Pineal mediation of the thermoregulatory and behavioral activating effects of β-endorphin. Peptides 3: 679–685, 1982.

    Article  PubMed  CAS  Google Scholar 

  88. Roberts A.C., Martensz N.D., Hastings M.H., Herbert J.: Changes in photoperiod alter the daily rhythms of pineal melatonin content and hypothalamic β-endorphin content and the luteinizing hormone response to naloxone in the male Syrian hamster. Endocrinology 117: 141–148, 1985.

    Article  PubMed  CAS  Google Scholar 

  89. Kerdelhue B., Karteszi M., Pasqualini C., Reinberg A., Mezey E., Palkovits M.: Circadian variations in β-endorphin concentrations in pituitary and in some brain nuclei of the adult male rat. Brain Res. 261: 243–248, 1983.

    Article  PubMed  CAS  Google Scholar 

  90. Genazzani A.R., Criscuolo M., Bergamaschi M., Cleva M., Petraglia F., Trentini G.P.: Daily photoperiod and β-endorphin concentrations in medial basal hypothalamus and pituitary gland. In: Trentini G.P., De Gaetani C, Pévet P. (Eds.), Fundamentals and clinics in pineal research. Raven Press, New York, 1987, pp. 271–275.

    Google Scholar 

  91. Criscuolo M., Trentini G.P., Genazzani A.R., De Gaetani C., Ficarra G., Petraglia F., Bergamaschi M., Cleva M., De Ramundo B.M.: Photoperiod, pineal gland and daily changes in medial basal hypothalamic β-endorphin content in female rat. In: Reiter R.J., Lukaszyk A. (Eds.), Advances in pineal research: 4.John Libbey, London-Paris, 1990, pp. 161–168.

    Google Scholar 

  92. Zucker I.: Light-dark rhythms in rat eating and drinking behavior. Physiol. Behav. 6: 115–126, 1971.

    Article  PubMed  CAS  Google Scholar 

  93. Lutsch E.F., Morris R.W.: Light reversal of a morphine-induced analgesia susceptibility rhythm in mice. Experientia 27: 420–421, 1971.

    Article  PubMed  CAS  Google Scholar 

  94. Kavaliers M., Hirst M., Teskey G.C.: Aging, opioid analgesia and the pineal gland. Life Sci. 32: 2279–2287, 1983.

    Article  PubMed  CAS  Google Scholar 

  95. Genazzani A.R., Trentini G.P., Petraglia F., De Gaetani C., Criscuolo M., Ficarra G., De Ramundo B.M., Cleva M.: Estrogens modulate the diurnal rhythm of hypothalamic β-endorphin contents in female rats. Neuroendocrinology 52: 221–224, 1990.

    Article  PubMed  CAS  Google Scholar 

  96. Davis F.C.: Ontogeny of circadian rhythms. In: Aschoff J. (Ed.), Handbook of behavioral neurobiology, Vol. 4, Biological rhythms. Plenum Press, New York, 1981, pp. 257–270.

    Google Scholar 

  97. Weaver D.R., Reppert S.M.: Maternal melatonin communicates day length to the fetus in Djungarian hamsters. Endocrinology 119: 2861–2863, 1986.

    Article  PubMed  CAS  Google Scholar 

  98. Stetson M.H., Horton T.H., Donhan R.S.: Prenatal and postnatal functions of the biological clock in reproductive development. In: Schreibman M.P., Scanes C.G. (Eds.), Development, maturation, and senescence of neuroendocrine systems. A comparative approach. Acad. Press, San Diego, 1989, pp. 173–194.

    Google Scholar 

  99. Stetson M.H., Horton T.H., Ray S.L.: Participation of the maternal pineal in communication of photoperiodic information to the fetus: site of action of melatonin. V Coll. Europ. Pineal Study Group, Guildford, 1990, p. 137 (abstract).

    Google Scholar 

  100. Murakami N., Hayafuji C, Sasaki Y., Yamazaki J., Takahashi K.: Melatonin accelerates the reentrainment of the circadian adreno-cortical rhythm in inverted illumination cycle. Neuroendocrinology 36: 385–391, 1983.

    Article  PubMed  CAS  Google Scholar 

  101. Arendt J., Aldhous M., English J., Marks V., Arendt J.H.: Some effects of jet-lag and their alleviation by melatonin. Ergonomics 30: 1379–1393, 1987.

    Article  Google Scholar 

  102. Redman J.R., Armstrong S.M.: Reentrainment of rat circadian activity rhythms: effects of melatonin. J. Pineal Res. 5: 203–215, 1988.

    Article  PubMed  CAS  Google Scholar 

  103. Illnerova H., Trentini G.P., Maslova L.: Melatonin accelerates reentrainment of the circadian rhythm of its own production after an 8-h advance of the light-dark cycle. J. Comp. Physiol. A, 166: 97–102, 1989.

    Article  PubMed  CAS  Google Scholar 

  104. Cassone V.M., Roberts M.H., Moore R.Y.: Melatonin inhibits metabolic activity in the rat suprachiasmatic nuclei. Neurosci. Lett. 81: 29–34, 1987.

    Article  PubMed  CAS  Google Scholar 

  105. Peng M.T., Jiang M.J., Hsu H.K.: Changes in running-wheel activity, eating and drinking and their day/night distributions throughout the life-span of the rat. J. Gerontol. 35: 339–347, 1980.

    Article  PubMed  CAS  Google Scholar 

  106. Roozendaal B., Van Gool W.A., Swaab D.F., Hoogendijk J.E., Mirmiran M.: Changes in vasopressin cells of the rat suprachiasmatic nucleus with aging. Brain Res. 409: 259–264, 1987.

    Article  PubMed  CAS  Google Scholar 

  107. Mobbs C.V.: Neurohumoral hysteresis as a mechanism for aging in humans and other species: comparative aspects. In: Schreibman M.P., Scanes C.G., (Eds.), Development, maturation, and senescence of neuroendocrine systems. A comparative approach. Acad. Press, San Diego, 1989, pp. 223–252.

    Google Scholar 

  108. Rozencwaig R., Grad B.R., Ochoa J.: The role of melatonin and serotonin in aging. Med. Hypotheses 23: 337–352, 1987.

    Article  PubMed  CAS  Google Scholar 

  109. Ader R.: Psychoneuroimmunology. Acad. Press., New York, 1981.

    Google Scholar 

  110. Blalock J.E., Bost K.L.: Neuroimmunoendocrinology. Prog. Allergy, Vol. 43, Karger, Basel, 1988.

    Google Scholar 

  111. Bost K.L.: Hormone and neuropeptide receptors on mononuclear leukocytes. Prog. Allergy, Vol. 43, Karger, Basel, 1988, pp. 68–83.

    Google Scholar 

  112. Johnson H.M., Torres B.A.: Immunoregulatory properties of neuroendocrine peptide hormones. Prog. Allergy, Vol. 43, Karger, Basel, 1988, pp. 37–67.

    Google Scholar 

  113. Ritchie A.W., Oswald I., Micklem H.S., Boyd J.E., Elton R.A., Jazwinska E., James K.: Circadian variation of lymphocyte subpopulations: a study with monoclonal antibodies. Br. Med. J. 286: 1773–1775, 1983.

    Article  CAS  Google Scholar 

  114. Canon C., Levi F., Touitou Y., Sulon J., Demey-Ponsart E., Reinberg A., Mathé G.: Circadian and seasonal changes of the inducer/suppressor ratio (OKT4+/OKT8+) in venous blood of healthy adults. C.R. Acad. Sci. (III) 302: 519–524, 1986.

    CAS  Google Scholar 

  115. Bratescu A., Teodorescu M.: Circannual variation in the B cell/T cell ratio in normal human peripheral blood. J. Allergy Clin. Immunol. 68: 273–280,. 1981.

    Article  PubMed  CAS  Google Scholar 

  116. Pasqualetti P., Colantonio D., Casale R., Colangeli S., Natali G.: Ritmo circadiano delle sottopopolazioni linfocitarie umane. Quad. Sclavo Diagn. 24: 89–96, 1988.

    PubMed  CAS  Google Scholar 

  117. Maestroni G.J.M., Conti A., Pierpaoli W.: Role of the pineal gland in immunity. I. Circadian synthesis and release of melatonin modulates the antibody response and antagonizes the immunosuppressive effects of corticosterone. J. Neuroimmunol. 13: 19–30, 1986.

    CAS  Google Scholar 

  118. Maestroni G.J.M., Conti A., Pierpaoli W.: Melatonin counteracts the effects of acute stress on the immune system via an opiatergic system. In: Trentini G.P., De Gaetani C.F., Pévet P. (Eds.), Fundamentals and clinics in pineal research. Raven Press, New York, 1987, pp. 277–279.

    Google Scholar 

  119. Del Gobbo V., Libri V., Villani N., Caliò R., Nisticò G.: Role of the pineal gland in the control of interleukin-2 production and natural killer activity in mice. In: Hadden J.W., Masek K., Nisticò G. (Eds.), Interactions among CNS, neuroendocrine and immune systems. Pythagora Press, Rome-Milan, 1989, pp. 81–91.

    Google Scholar 

  120. Pierpaoli W., Maestroni G.J.M.: Melatonin: a principal neuroimmunoregulatory and anti-stress hormone: its anti-aging effects. Immunol. Lett. 16: 355–362, 1987.

    Article  PubMed  CAS  Google Scholar 

  121. Mehrishi J.N., Mills I.H.: Opiate receptors on lymphocytes and platelets in man. Clin. Immunol. Immunopathol. 27: 240–249, 1983.

    Article  PubMed  CAS  Google Scholar 

  122. Hazum E., Chang K.J., Cuatrecasas P.: Specific non-opiate receptors for beta endorphin. Science 205: 1033–1035, 1979.

    Article  PubMed  CAS  Google Scholar 

  123. Gilman S.C., Schwartz J.M., Milner R.J., Bloom F.E., Feldman J.D.: β-endorphin enhances lymphocyte proliferative responses. Proc. Natl. Acad. Sci. USA 79: 4226–4230, 1982.

    Article  PubMed  CAS  Google Scholar 

  124. McCain H.W., Lamster J.B., Bozzone J.M., Grbic J.T.: β-endorphin modulates human immunity via non-opiate receptor mechanisms. Life Sci. 31: 1619–1624, 1982.

    Article  PubMed  CAS  Google Scholar 

  125. Shavit Y., Lewis J.W., Terman G.W., Gale R.P., Liebeskind J.C.: Opioid peptides mediate the suppressive effect of stress on natural killer cell cytotoxicity. Science 223: 188–190, 1984.

    Article  PubMed  CAS  Google Scholar 

  126. Kay N., Allen J., Morley J.E.: Endorphins stimulate normal human peripheral blood lymphocyte natural killer activity. Life Sci. 35: 53–59, 1984.

    Article  PubMed  CAS  Google Scholar 

  127. Foster J.S., Moore R.N.: Dynorphin and related opioid peptides enhance tumoricidal activity mediated by murine peritoneal macrophages. J. Leucocyte Biol. 42: 171–174, 1987.

    CAS  Google Scholar 

  128. Angeli A., Paccotti P., Piovesan A., Terzolo M.: La pineale. Una ghiandola endocrina dimenticata. Fed. Med. 42: 83–87, 1989.

    Google Scholar 

  129. Fillion M.P., Prudhomme N., Haour F., Fillion G., Bonnet M., Lespinats G., Masek K., Flagel M., Corvaia N., Launay J.M.: Hypothetical role of the serotonergic system in neuroimmunomodulation: preliminary molecular studies. In: Hadden J.W., Masek K., Nisticó G. (Eds.), Interactions among CNS, neuroendocrine and immune systems. Pythagora Press, Rome-Milan, 1989, pp. 235–250.

    Google Scholar 

  130. Mašek K., Horák P., Kadlec D., Flegol M.: The interactions between neuroendocrine and immune systems at the receptor level. The possible role of serotonergic system. In: Hadden J.W., Masek K., Nisticó G. (Eds.), Interactions among CNS, neuroendocrine and immune systems. Pythagora Press, Rome-Milan, 1989, pp. 225–234.

    Google Scholar 

  131. Ames B.N., Saul R.L.: Oxidative DNA damage, cancer and aging. In: Cross C.E. (moderator), Oxygen radicals and human disease. Ann. Intern. Med. 107: 536–539, 1987.

    Google Scholar 

  132. Blask D.E.: The pineal: an oncostatic gland? In: Reiter R.J. (Ed.), The pineal gland. Raven Press, New York, 1984, pp. 253–284.

    Google Scholar 

  133. Blask D.E., Hill S.M., Pelletier D.B., Anderson J.M., Lenus-Wilson A.: Melatonin: an anticancer hormone of the pineal gland. In: Reiter R.J., Pang S.F. (Eds.), Advances in pineal research: 3.John Libbey, London-Paris, 1989, pp. 259–263.

    Google Scholar 

  134. Bartsch H., Bartsch C., Ebels I., Simon W.: Antitumor activity of the pineal: the effect of unidentified substances versus that of melatonin. V Coll. Europ. Pineal Study Group, Guildford 1990, p. 11 (abstract).

    Google Scholar 

  135. Hill S.M., Blask D.E.: Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture. Concer Res. 48: 6121–6126, 1988.

    CAS  Google Scholar 

  136. L’Hermite-Balériaux M., L’Hermite M., Pasteels J.L., de Launoit Y.: Effect of melatonin on the proliferation of human mammary cancer cells in culture. V Coll. Europ. Pineal Study Group, Guildford 1990, p. 69 (abstract).

    Google Scholar 

  137. Blask D.E., Hill S.M.: Melatonin and cancer: basic and clinical aspects. In: Miles A., Thompson C., Philbrick D.R.S. (Eds.), Melatonin: clinical perspectives. Oxford Univ. Press, Oxford, 1988, pp. 128–138.

    Google Scholar 

  138. Osborne C.K.: Effects of estrogens and antiestrogens on human breast cancer cell proliferation: in vitro studies in tissue culture and in vivo studies in athymic mice. In: Hollander V.P. (Ed.), Hormonally responsive tumors. Academic Press, Orlando, 1985, pp. 93–113.

    Google Scholar 

  139. Cos S., Blask D.E.: Effects of melatonin on growth factors activity in MCF-7 human breast cancer cells. V Coll. Europ. Pineal Study Group, Guildford 1990, p. 28 (abstract).

    Google Scholar 

  140. Scaglione F., Cella S.G., Locatelli V., Demartini G., Fraschini F.: Melatonin interferes with GH and IGF-1. V Coll. Europ. Pineal Study Group, Guildford, 1990, p. 124 (abstract).

    Google Scholar 

  141. Lewis J.W., Shavit Y., Terman G.W., Nelson L.R., Gale R.P., Liebeskind J.C.: Apparent involvement of opioid peptides in stress-induced enhancement of tumor growth. Peptides 4: 635–638, 1983.

    Article  PubMed  CAS  Google Scholar 

  142. Shavit Y., Terman G.W., Martin F.C., Lewis J.W., Liebeskind J.C., Gale R.P.: Stress, opioid peptides, the immune system, and cancer. J. Immunol. 135 (suppl. 2): 834–837, 1985.

    Google Scholar 

  143. Tamarkin L., Cohen M., Roselle D., Reichert C., Lippman M., Chabner B.: Melatonin inhibition and pinealectomy enhancement of 7, 12-dimethyl-benz(a) anthracene-induced mammary tumors in the rat. Cancer Res. 41: 4432–4436, 1981.

    PubMed  CAS  Google Scholar 

  144. Vinnitsky V.B.: Neurohumoral mechanisms of immunosuppression in cancer: possibilities of correction. I Stromboli Conf. on Aging and Cancer, Stromboli, 1987, p. 20 (abstract).

    Google Scholar 

  145. Timiras P.S., Cole G., Croteau M., Hudson D.B., Miller C., Segall P.E.: Changes in brain serotonin with aging and modification through precursor availability. In: Agnoli A., Crepaldi G., Spano P.F., Trabucchi M. (Eds.), Aging Series vol. 23, Aging brain and ergot alkaloids. Raven Press, New York, 1983, pp. 23–32.

    Google Scholar 

  146. Dilman V.M., Anisomov V.N., Ostroumova M.N.: Increase in lifespan of rats following polypeptide pineal extract treatment. Exp. Pathol. 17: 539–545,1979.

    Google Scholar 

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  1. Institute of Pathological Anatomy, University of Modena, Policlinico, Via del Pozzo 71, 41100, Modena, Italy

    Gian Paolo Trentini, C. De Gaetani & M. Criscuolo

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Paolo Trentini, G., De Gaetani, C. & Criscuolo, M. Pineal gland and aging. Aging Clin Exp Res 3, 103–116 (1991). https://doi.org/10.1007/BF03323987

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