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Effect of the substitution of 3-methyl group on the carcinogenic activitiy of 2-naphthylamine

  • Published:
Proceedings / Indian Academy of Sciences

Abstract

The carcinogenic activity of 3-methyl-2-naphthylamine (II) and its hydrochloride has been investigated with a view to studying the effect of 3-methyl substituent on the carcinogenic activity of 2-naphthylamine (I). It has been observed that:

(1) Compared to compound (I), compound (II) is more carcinogenic to mice and rats. (2) Female rats are more susceptible than the male rats for the induction of tumour by (II) and its hydrochloride. (3) The subcutaneous injections of (II) induced fibrosarcomas in mice while the injections of its hydrochloride produced hemangioendotheliomas, local as well as at sites, distant from the site of application. From the biological activity of compound (II) it is inferred that the methyl group in (II) is involved in thein vivo carcinogenesis.

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References

  1. Bonser, G. M.,et al...Brit. J. Cancer, 1952,6, 412–24.

    PubMed  CAS  Google Scholar 

  2. .. Ibid., 1956,10, 533–38.

    PubMed  CAS  Google Scholar 

  3. Ciba Foundation Symposium on Carcinogenesis,Mechanisms of Action, Boston, Little, 1958, pp. 197–217.

  4. Deringer, M. K....J. Nat. Can. Inst., 1956,17, 533–38.

    CAS  Google Scholar 

  5. Haddow, A.,et al...Phil. Trans. Roy. Soc. London, s. A, 1948,241, 147–95.

    Article  Google Scholar 

  6. Hueper, W. C.,et al...J. Indust. Hyg. and Toxicol., 1938,20, 46–84 and 85–91.

    CAS  Google Scholar 

  7. —— and Wolfe, H. D...Am. J. Path., 1937,13, 656.

    Google Scholar 

  8. Kanekar, M. G. and Panse, T. B.Proc. Ind. Acad. Sci., 1966,64 B, 114–20.

    Google Scholar 

  9. Miller, J. A.,et al...Cancer Research, 1955,15, 188–99.

    PubMed  CAS  Google Scholar 

  10. Miller, E. C.,et al... Ibid., 1956,16, 525–34.

    PubMed  CAS  Google Scholar 

  11. Miller, J. A. and Miller, E. C. Ibid., 1961,21, 1068–72.

    PubMed  CAS  Google Scholar 

  12. Schar, W...Deutsche Ztschr. f. Chir., 1930,226, 81.

    Google Scholar 

  13. Spitz, S., Maguigan, W. H. and Dobriner, K.Cancer, 1950,3, 789–804.

    Article  PubMed  CAS  Google Scholar 

  14. Shenoy, K. P., Ambaye, R. Y. and Panse, T. B.Curr. Sci., 1964,33, 45–46.

    CAS  Google Scholar 

  15. Venkataraman, K. .. Personal communication.

  16. Vesely, V. and Štursa, F.Chem. Zentr., 1934,1, 3589.

    Google Scholar 

Download references

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Authors and Affiliations

  1. Indian Cancer Research Centre, Bombay

    M. G. Kanekar & T. B. Panse

  2. Tata Memorial Hospital, Bombay

    G. V. Talwalkar

Authors
  1. M. G. Kanekar
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  2. T. B. Panse
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  3. G. V. Talwalkar
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Additional information

Communicated by Dr. V. R. Khanolkar,f.a.sc.

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Kanekar, M.G., Panse, T.B. & Talwalkar, G.V. Effect of the substitution of 3-methyl group on the carcinogenic activitiy of 2-naphthylamine. Proc. Indian Acad. Sci. 65, 257–266 (1967). https://doi.org/10.1007/BF03052550

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  • DOI: https://doi.org/10.1007/BF03052550

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