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PET kinetic analysis —Pitfalls and a solution for the Logan plot

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Abstract

The Logan plot is a widely used algorithm for the quantitative analysis of neuroreceptors using PET because it is easy to use and simple to implement. The Logan plot is also suitable for receptor imaging because its algorithm is fast. However, use of the Logan plot, and interpretation of the formed receptor images should be regarded with caution, because noise in PET data causes bias in the Logan plot estimates. In this paper, we describe the basic concept of the Logan plot in detail and introduce three algorithms for the Logan plot. By comparing these algorithms, we demonstrate the pitfalls of the Logan plot and discuss the solution.

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Authors and Affiliations

  1. Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1-1 Naka, Itabashi, 173-0022, Tokyo, Japan

    Yuichi Kimura & Mika Naganawa

  2. Japanese Society for the Promotion of Science, Japan

    Mika Naganawa

  3. Molecular Imaging Center, National Institute of Radiological Sciences, Japan

    Miho Shidahara & Yoko Ikoma

  4. Department of Investigative Radiology, National Cardiovascular Center Research Institute, Japan

    Hiroshi Watabe

Authors
  1. Yuichi Kimura
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  2. Mika Naganawa
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  3. Miho Shidahara
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  4. Yoko Ikoma
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  5. Hiroshi Watabe
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Correspondence to Yuichi Kimura.

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Kimura, Y., Naganawa, M., Shidahara, M. et al. PET kinetic analysis —Pitfalls and a solution for the Logan plot. Ann Nucl Med 21, 1–8 (2007). https://doi.org/10.1007/BF03033993

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  • DOI: https://doi.org/10.1007/BF03033993

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