Abstract
To clarify the influence of iron deficiency on mineral status, the following two synthetic diets were fed to male Wistar rats: a control diet containing 128 μg iron/g, and an iron-deficient diet containing 5.9 μg iron/g. The rats fed the iron-deficient diet showed pale red conjunctiva and less reactiveness than the rats fed the control diet. The hemoglobin concentration and hematocrit of the rats fed the irondeficient diet were markedly less than the rats fed the control diet. The changes of mineral concentrations observed in tissues of the rats fed the iron-deficient diet, as compared with the rats fed the control diet, are summarized as follows:
-
• Iron concentrations in blood, brain, lung, heart, liver, spleen, kidney, testis, femoral muscle, and tibia decreased;
-
• Calcium concentrations in blood and liver increased; calcium concentration in lung decreased;
-
• Magnesium concentration in blood increased;
-
• Copper concentrations in blood, liver, spleen and tibia increased; copper concentration in femoral muscle decreased;
-
• Zinc concentration in blood decreased;
-
• Manganese concentrations in brain, heart, kidney, testis, femoral muscle and tibia increased.
These results suggest that iron deficiency affects mineral status (iron, calcium, magnesium, copper, zinc, and manganese) in rats.
Similar content being viewed by others
References
S. J. Baker and V. I. Methan,Iron Metabolism and Its Disorders, H. Kief, ed., Excerpta Medica, Amsterdam, 1975, pp. 145–158.
A. S. Prasad, J. A. Halsted, and M. Nadimi,Am. J. Med. 31, 532–546 (1961).
C. A. Finch,Ann. NY Acad. Sci. 300, 221–227 (1977).
G. K. Davis,Ann. NY Acad. Sci. 355, 130–139 (1980).
F. H. Nielsen,Ann. NY Acad. Sci. 355, 152–164 (1980).
M. Kimura and Y. Itokawa,Magnesium in Health and Disease, Y. Itokawa and J. Durlach, eds., John Libbey, London, Paris, 1989, pp. 95–102.
R. G. Kay and C. Tasman-Jones,Aust. NZ Surg. 45, 325–330 (1975).
J. T. Karpel and V. H. Peden,J. Pediatr. 80, 32–36 (1972).
D. H. Coleman, A. R. Stevens, Jr., and C. A. Finch,Blood 10, 567–581 (1955).
H. N. Munro and M. C. Linder,Physiol. Rev. 58, 317–396 (1978).
S. Ratner,J. Dent. Res. 15, 89–92 (1935).
J. Glover and A. Jacobs,Br. Med. J. 2, 627, 628 (1972).
T. L. Sourkes, K. Lloyd, and H. Birnbaum,Can. J. Biochem. 46, 267–271 (1968).
C. A. Owen,Am. J. Physiol. 224, 514–518 (1973).
A. R. Sherman and N. T. Tissue,J. Nutr. 111, 266–275 (1981).
A. R. Sherman,Nutr. Res. 1, 363–372 (1981).
M. A. Johnson and J. M. Gratzek,J. Nutr. 116, 2443–2452 (1986).
S. E. Smith and M. Medlicott,Am J. Physiol. 141, 354–358 (1944).
A. B. R. Thomson, D. Olatunbosun, and L. S. Valberg,J. Lab. Clin. Med. 78, 642–655 (1971).
S. Pollack, J. N. George, R. C. Reba, R. M. Kaufman, and W. H. Crosby,J. Clin. Invest. 44, 1470–1473 (1965).
I. Mena, K. Horiuchi, and G. Lopez,J. Nucl. Med. 15, 516A (1974).
I. Mena, K. Horiuchi, K. Burke, and G. C. Cotzias,Neurology 19, 1000–1006 (1969).
I. Mena, O. Marin, S. Fuenzalida, and G. C. Cotzias,Neurology 17, 128–136 (1967).
G. C. Cotzias, K. Horiuchi, S. Fuenzalida, and I. Mena,Neurology 18, 376–382 (1968).
A. Pentschew, and F. F. Ebner,J. Neuropathol. Exp. Neurol. 22, 488–499 (1963).
H. Suzuki, O. Wada, K. Inoue, H. Tosaka, and T. Ono,Toxicol. Appl. Pharmacol. 71, 422–429 (1983).
M. E. Shils,JAMA 220, 1721–1729 (1972).
K. Yokoi, M. Kimura, A. Matsuda, H. Kabata, Y. Itokawa, M. Kataoka, and M. Sato,Jpn. J. Hug. 44, 831–838 (1989) (Japanese).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yokoi, K., Kimura, M. & Itokawa, Y. Effect of dietary iron deficiency on mineral levels in tissues of rats. Biol Trace Elem Res 29, 257–265 (1991). https://doi.org/10.1007/BF03032682
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF03032682