Abstract
Eighteen mongrel dogs were divided into three equal groups. Spinal cord and spinal durat blood flow in the cervical, thoracic and lumbosacral regions were measured using the radioactive microsphere technique. Measurements were taken before and 10 and 40 minutes after lumbar subarachnoid injection of one of the following: (I) physiologic saline; (2) epinephrine200 μg or (3) phenylephrine 5 mg. No significant change in spinal cord blood flow occurred in any of the groups, nor was there any difference between the groups. Dogs receiving subarachnoid phenylephrine did demonstrate a significant reduction of thoracic dura! blood flow at ten minutes. Dogs receiving intraihecal epinephrine or phenylephrine demonstrated a significant reduction in lumbosacral dural blood flow at ten minutes after injection. The reduction in dural blood flow was still evident at 40 minutes in dogs receiving phenylephrine. Subarachnoid epinephrine (200 μ.g) and phenylephrine (5 mg) do not effect spinal cord blood flow but do produce regional dural vasocomtriction.
Résumé
Chez 18 chiens bâtards répartis en trois groupes égaux, le flux sanguin de la moelle épiniere et de la duremère a été mesuré dans les régions cervkales, thoraciques et lombosacrées par microsphères radioactives. Les mesures ont été effectiées avant el 10 minutes et 40 minutes après l’ injection de l’ un des produits suivants: 1) soluté salin, 2) épinéphrine 200 μg, 3) phényléephrine 5 mg. On n’a pas observé de changement notable de la perfusion médullaire dans aucun groupe et aucune difference n’a été observée d’un groupe à 1’autre.
Seule la perfusion duremérienne a été modifiée par les injections comme suit: la phényléphrine sous-arach-noi ïdienne a réduit de façon significative le flux dure-mérien thoracique dix minutes après I’injection. De même on a observé une réduction significative du flux dure-mérien lombo-sacré dix minutes après I’ injection a“ epinéphrine et de phényléphrine; cette diminution du flux duremérien était encore présents 40 minutes après I’injection de phényléphrine. On en concittt que dans ce modèle expérimental, I’ épinéphrine sous-arachnoi-dienne (200 μg) et la phényléphrine (5 mg) ne modifient pas le flux médullaire mais provoquent une vasoconstriction dans la circulation duremérienne régionale.
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References
Braun H. Lokal Anesthesie, ed. 1, Leipsig, JA Barth, 1905. Braun H,: Local Anesthesia Ed. 3 (translated by P. Shields), p. 143, Philadelphia, 1914, Lea and Febiger.
Bonka JJ, Backup PH, Pratt WH. The use of vasoconstrictors to prolong spinal anesthesia. Anesthesiology 1951; 12:431–40.
Moore DC, Brtdenbaugh LD. Spinal (subarachnoid) block. JAMA 1966; 195:907–12.
Weiner N. Norepinephrine, epinephrine and the sympathomimetic amines in the pharmacological basis of therapeutics. Edited by Gilman AG, Goodman LS, Gilman A. New York: MacMillan Publishing Co. Inc. (1980). Chapter 8, 138–75.
Biberfield J. Uber die Dosierung des in den Wirbel-kanal Gespritzen Suprarenins. Deutsche Med. Wehnschr 33: 549, 1907. Quoted by Braun (ref 1, p 143).
Usubiaga JE, Gollan F, Yannakakis Z, Johnson A. The effect of epidural and subarachnoid epinephrine upon spinal cord blood flow. Abstracts, Annual Meeting, American Society of Anesthesiologists, San Francisco, 1969, 57.
Hales JRS, Yeo JD, Stabback S. Effect of anesthesia and laminectomy on regional spinal cord blood flow in conscious sheep. J Neurosurg 1981; 554:620–6.
Hales JRS. Radioactive microsphere techniques for studies of the circulation. Clin Exper Pharmacol Physiol 1974, Suppl 1, 31–46.
Heymann MA, Payne BD, Hoffman JIE, Rudolph AM. Blood flow measurements with radionuclide labelled particles. Progr Cardiovasc Dis 1977; 20:55–79.
Griffiths IR. Spinal cord blood flow in dogs; the effect of blood pressure. J Neurol Neurosurg Psych 1973; 36:914–20.
Griffiths IR. Spinal cord blood flow in dogs. 2. The effect of the blood gases. J Neurol Neurosurg Psych 1973; 36:42–9.
Hales JRS. Effects of exposure to hot environments on total and regional blood flow in the brain and spinal cord of the sheep, Pfluegers Arch 1973; 334:327–37.
Nathan PW, Sears TA. Differential nerve block by sodium-free and sodium-deficient solutions. J Physiol 1962; 164:375–94.
Sandier AN, Tator CH. Review of the measurement of normal spinal cord blood flow. Brain Research 1976; 118:181–98.
Marcus ML, HerstadDD, Ehrhardt JC, Abboud FM. Regulation of total and regional spinal cord blood flow. Circ Res 1977; 41:128–34.
Moore RA, Bullingham RES, McQuay HJ et al. Dural permeability to narcotics: in vitro determination and application to extradural administration. BrJ Anaesth 1982; 54:1117–28.
Chambers WA, Littlewood DG, Logan MR, Scott DB. Effect of added epinephrine on spinal anesthesi a with lidocaine. Anesth Analg 1981; 60:417–20.
Chambers WA, Littlewood DG, Scott DB. Spinal anesthesia with hyperbaric bupivacaine effect of added vasoconstrictors. Anesth Analg 1982; 61:49–52.
Demon DD, Bridenbaugh PO, Turner PA, Phero JC, Raj PP. Neural blockade and pharmacokinetics following subarachnoid lidocaine in the rhesus monkey. L. Effects of epinephrine. Anesth Analg 1982;61:746–50.
Denson DD, Turner PA, Bridenbaugh PO, Thompson GA. Pharmacokinetics and neural blockade after subarachnoid lidocaine in the rhesus monkey. III. Effects of phenylephrine. Anesth Analg 1984; 63:129–33.
Reddy SVR, Yaksh TL. Spinal noradrenergic terminal system mediates antinociception. Brain Research 1980; 189:391–401.
Collins JG, Matsumoto M, Kitahata LM. Suppression by spinally administered epinephrine of noxiously evoked dorsal horn neuron activity in cats: evidence for spinal epinephrine analgesia. Anesth Analg 1983; 62:253–4.
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Supported by the Health Sciences Centre Research Foundation, Grant Number 387-3111-29.
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Kozody, R., Palahniuk, R.J., Wade, J.G. et al. The effect of subarachnoid epinephrine and phenylephrine on spinal cord blood flow. Can Anaesth Soc J 31, 503–508 (1984). https://doi.org/10.1007/BF03009534
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DOI: https://doi.org/10.1007/BF03009534