Summary
Serum free fatty acid and blood glucose levels were determined in 30 children under halothane, thiopentone and ketamine anaesthesia. Blood sugar is increased above baseline values by halothane 54.75 per cent (+++), thiopentone 71.7 per cent (++++) and ketamine 12.2 per cent (+) anaesthesia. Serum free fatty acid was increased during halothane 58.7 per cent (+++) and thiopentone 34.4 per cent (++) anaesthesia, but was decreased with ketamine anaesthesia 13.4 percent (-).
It is assumed that several factors contribute to these changes and are related either to the sympathetic nervous system or basal metabolism and to the specific actions of each drug.
RéSUMé
Chez 30 enfants anesthésiés à l’halothane, au thiopentone et à la kétamine, on a mesuré le taux d’acide gras circulant et la glycémie. Ces trois agents augmentent la glycémie à des degrés divers: halothane 54.75 pour cent, thiopentone 71.7 pour cent et kétamine 12.2 pour cent. Le taux d’acide gras circulant augmente durant l’anesthésie à l’halothane (58.7 pour cent) et au thiopentone (34.4 pour cent) mais diminue durant l’anesthésie à la kétamine (-13.4 pour cent).
Plusieurs facteurs contribuent à ces changements qui sont attribuables ou bien l’activité du système nerveux sympathique sur le métabolisme basai ou à l’action spécifique de chaque agent.
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References
Dobkin, A.B. &Fedoruk, S.A. A comparison of the cardiovascular, respiratory and metabolic effects of methoxyflurane and halothane in dogs. Anesthesiology22: 355 (1961).
Gervenko, F.W. &Grene, N.M. Effect of cyclopropane anesthesia on glucose assimilation coefficient in man. Anesthesiology28: 914 (1967).
Galla, S.I. Glucose pool size, turnover rate and CO2 production during halothane anesthesia in dogs. Anesthesiology28: 251 (1967).
Galla, S.J. &Wilson, E.F. Hexose metabolism during halothane anesthesia in dogs. Anesthesiology25: 96 (1964).
Keating, V.,et al. Halothane and carbohydrate metabolism. Anesthesia14: 268 (1969).
Martinez, C. Effect of barbituric acid on alloxan diabetes in rats and dogs. Am. J. Physiology182: 267 (1955).
Hensel, I.,et al. Untersuchungen über Kreislauf- und Stoffwechselveränderungen unter Ketamine Narcose. Der Anaesthesist21: 44 (1972).
Duncomb, W.G. Colorometric method of determination of plasma nonesterified fatty acids. Clinical Ch. Act.9: 122 (1964).
Howorth, P.J.N.,et al. Evaluation of a colorometric method of determination of plasma nonesterified fatty acids. Clinical chem. Act.14: 69 (1966).
Werner, W., Rey, H.G., &Wielinger, H. Properties of a new chromogen for the determination of glucose in blood according to the GOD/POD (Glucose oxidase-peroxidase) method. Fresenicus Z. Anal. Chem. 1970. 252 (2-3) 224–8 (Germ.).
Hunter, A.R. Halothane and blood sugar. Anesthesiology31: 490 (1959).
Kaniaris,et al. Relation between glucose tolerance and serum insulin levels in humans before and after thiopental I.V. injection in humans. Acta Anesthesiologyca Hellenica6: 163 (1973).
Borgman, R.L.,et al. Effects of barbiturates on skeletal muscle function. Anesthesiology21: 150 (1960).
Bortels, E.C. Basal metabolism testing under pentothal anesthesia. J. Clin. Endocrinology9: 1190 (1949).
Brody, J.M. &Bain, S.A. Effect of barbiturates on oxidative Phosphorylation. Proc. Soc. exp. biol. Medicine77: 50 (1957).
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An erratum to this article is available at http://dx.doi.org/10.1007/BF03013418.
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Kaniaris, P., Lekakis, D., Kykoniatis, M. et al. Serum free fatty acid and blood sugar levels in children under halothane, thiopentone and ketamine anaesthesia (comparative study). Canad. Anaesth. Soc. J. 22, 509–518 (1975). https://doi.org/10.1007/BF03004867
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DOI: https://doi.org/10.1007/BF03004867