Summary
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1.
In the treatment of diabetes mellitus one should strive not merely to keep a patient comfortable and free from insulin reactions but also to control his diabetic state, namely his hyperglycemia.
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By the control of hyperglycemia, we automati cally control all the other factors (glycosuria, ketonuria, weight, etc.).
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3.
Hyperglycemia has a deleterious effect on a diabetic state which thus becomes progressive and a more severe diabetic state results.
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For the proper control of any diabetic condition, one needs extensive daily blood sugar studies which alone will enable one to distribute the insulin dosage wisely and adequately. Without such studies one has to work in the dark and do much guessing, and that usually at the patient’s expense.
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References
Tolstoi, E., Almy, T. P. and Toscari, V.: Treatment of Diabetes Mellitus with Protamine Insulin: Is a Persistent Glycosuria Harmful? A Metabolic Study of a Severe Case.Ann. Int. Med., 16: 893–904. 1942.
Lukens, F. D. W. and Dohan, F. C.: Pituitary-Diabetes in the Cat: Recovery Following Insulin or Dietary Treatment.Endocrinology 30: 175–202, 1942.
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John, H.J. Treatment of diabetes mellitus without regard to hyperglycemia and glycosuria. Jour. D. D. 10, 129–131 (1943). https://doi.org/10.1007/BF03004156
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DOI: https://doi.org/10.1007/BF03004156