Abstract
Cancer patients have the highest prevalence of malnutrition of any group of hospitalized patients. The presence of the tumor alone may lead to reduced intake of different nutrients and treatment modalities such as surgery, chemotherapy and radiation therapy may further exacerbate nutritional disturbances. Dietary manipulation in experimental systems has shown improvement of tumor response to cancer therapy. Drug pharmacokinetics has been shown to be altered by changes in nutritional delivery. This article reviews the present knowledge, from experimental and clinical standpoints, of the potential role of different nutritional factors on the specific cancer treatment. It is obvious that alteration of at least some dietary factors affect the outcome of different forms of cancer treatment. Indeed, although interest in the clinical significance of optimal dietary intake and supplementation during cancer therapy so far remain marginal, accumulating data indicate that this area deserves further research attention.
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References
Goldin A: Dosing and sequencing for antineoplastic synergism in combination chemotherapy.Cancer 54, 1155 (1984).
Steel G G: The search for therapeutic gain in the combination of radiotherapy and chemotherapy.Radiother Oncol 11, 31 (1988).
Henriksson R, Grankvist K: Interactions of clinically used drugs with cancer treatment.Acta Oncol (in press).
Toothaker R D, Welling P G: The effect of food on drug bioavailability.Am Rev Pharmacol Toxicol 20, 173 (1980).
Chlebowski R T: Critical evaluation of the role of nutritional support with chemotherapy.Cancer 55, 268 (1985).
Welling P G: Influence of food and diet on gastrointestinal drug absorption. A Review.J pharmacol Biopharm 5, 293.
Adair C G, Bridges J M, Desai Z R: Can food affect the bioavailability of chlorambucil in patients with haematological malignancies?Cancer Chemother Pharmacol 17, 99 (1986).
Adair C G, McElnay J C: The effect of dietary amino acids on the gastrointestinal absorption of melphalan and chlorambucil.Cancer Chemother Pharmacol 19, 343 (1987).
Bosanquet A G, Gilby E D: Pharmacokinetics of oral and intravenous melphalan during routine treatment of multiple myeloma.Eur J clin Oncol 18, 355 (1982).
Bosanquet A G, Gilby E D: Comparison of fed and fasting states on the absorption of melphalan in multiple myeloma.Cancer Chemother Pharmacol 12, 183 (1984).
Burton N K, Barnett M J, Aherne G W, Evans J D I, Lister T A: Short communication. The effect of food on the oral administration of 6-mercaptopurine.Cancer Chemother Pharmacol 18, 90 (1986).
Harvey L P, Mehta B M, Bonau R A, Daly J M: Alteration of rnethotrexate pharmacokinetics and host toxicosis in rats by dietary manipulation.Surgical Pharm 35, 397 (1984).
McAnena O J, Ridge J A, Daly J M: Alteration of methotrexate metabolism in rats by administration of an elemental liquid diet.Cancer 59, 1091 (1987).
Gunnarsson P-O, Davidsson T, Andersson S-B, Backman C, Johansson S-Å: Impairment of estramus- tine phosphate absorption by concurrent milk and food intake.Eur J clin Pharmacol (in press).
Chatterji D C, Yeager R L, Gallelli J T: Kinetics of chlorambucil hydrolysis using high pressure liquid chromatography.J Pharm Sci 71, 50 (1982).
Hocman G: Prevention of cancer: Restriction of nutritional energy intake (joules).Comp Biochem Physiol 91A (2), 209 (1988).
Prasad K N, Sinha P K, Ramanujam M,et al.: Sodium ascorbate potentiates the growth inhibitory effect of certain agents on neuroblastoma cells in culture.Proc natn Acad Sci USA 76, 829 (1979).
Myers C: Anthracyclines.Cancer Chemother 8, 52 (1986).
Grankvist K, Henriksson R: Doxorubicin and epirubicin iron-induced generation of free radicalsin vitro. A comparative study.Biosc Rep 7, 653 (1987).
Herman E H, Ferrans V J, Myers C E, Van Vleet J F: Comparison of the effectiveness of 1,2-bis(3,5-dioxopiperazinyl-1-yl) propane (ICRF-187) andN-acetylcysteine in preventing chronic doxorubicin cardiotoxicity in beagles.Cancer Res 45, 276 (1985).
Herman E H, Ferrans V J: Pretreatment with ICRF- 187 provides long-lasting protection against chronic daunorubicin cardiotoxicity in rabbits.Cancer Chemother Pharmacol 16, 102 (1986).
Henriksson R, Grankvist K: Protective effect of iron chelators on epirubicin-induced fibroblast toxicity.Cancer Lett 43, 179 (1988).
Satyamoorthy K, Chitnis M P, Pradham S G: Potentiation of hydroxyurea cytotoxicity by iron chelating agent in murine tumor models in vitro.Cancer Drug Delivery 3, 173 (1986).
Sinha B K: Free radicals in anticancer drug pharmacology.Chem Biol Interact 69, 293 (1989).
Barnes D, Sato G: Methods for growth of cultured cells in serumfree medium.Analyt Biochem 102, 255 (1980).
Lederman, H M, Cohen A, Lee J W W, Fredman M H, Gelfand E W: Deferoxamine: A reversible S-phase inhibitor of human lymphocyte proliferation.Blood 64, 748 (1984).
May W S, Jacobs S, Cuatrecasas P: Association of phorbol ester-induced hyperphosphorylation and reversible regulation of transfersive membrane receptors in HL60-cells.Proc natn Acad Sci USA 81, 2016 (1984).
Forsbeck K: Control of tumor cell growthin vitro: Influence of the pharbol diester TPA and cellular iron metabolism. Acta Universitatis Upsaliensis. Comprehensive summaries of Uppsala dissertations from the Medical Faculty, vol 129.
Speyer J Let al.: Protective effect of the bispiperazi- nedione ICRF-187 against doxorubicin-induced cardiac toxicity in women with advanced breast cancer.The New Engl J Med 319 (12), 745 (1988).
Lyman S, Ujjani B, Renner K, Antholine W, Petering D H, Whetstone J W, Knight J M: Properties of the initial reaction of bleomycin and severed of its metal complexes with Ehrlich cells.Cancer Res 46, 4472 (1986).
Baker G W, Duncan J R: Possible site of zinc control of hepatoma cell division.J natn Cancer Inst 70, 333 (1983).
Galatulas I, Bossa R: Effect of zinc supplementation on the antitumoural activity and toxicity of adria-mycin in mice.IRCS Med Sci 14, 942 (1986).
Dimitrov N V, Hay M B, Siew S, Hudler D A, Charamella L J, Ullrey D E: Abrogation of adriamycin-induced cardiotoxicity by selenium in rabbits.Am J Pathol 126, 376 (1987).
Zidenberg-Cherr S, Keen C L: Influence of dietary manganese and vitamin E on adriamycin toxicity in mice.Toxicol Lett 30, 79 (1986).
Garattini S, D’Incalci M: Combinations of anticancer agents with other drugs.Prog Cancer Res Ther 31, 296 (1984).
Cohen M H, Carbone P P: Enhancement of the antitumor effect of l,3-bis(2-chloroethyl)-l-nitrosourea and cyclophosphamide by vitamin A.J natn Cancer Inst 48, 921 (1972).
Weinzweig J, Mendecki J, Friedenthal E, Levenson S M, Seifter E: Lewis lung tumor therapy: Additive effects of Vitamin A and arginine supplements.Fedn Proc 45, 1078 (1986).
McCormick D L, Moon R C: Retinoid-tamoxifen interaction in mammary cancer chemoprevention.Carcinogenesis 7, 193 (1986).
Israel L, Hajji O, Grefft-Alami A, Desmoulins D, Succari M, Cals M J, Miocque M, Breau J L, Morere J F: Augmentation par la vitamine A des effets de la chimiotherapie dans les cancers du sein metastas es apres la menopause. Essai randomis e sur 100 malades.Ann Med Interne 136, 551 (1985).
Akman S A, Doroshow J H, Dietrich M F, Chlebow-ski R T, Block J S: Synergistic cytotoxicity between menadione and dicumarol vs. Murine Leukemia L1210.J Pharmacol Exp Ther 240, 486 (1987).
Gold J:In vivo Synergy of vitamin K3 and metho-trexate in tumor-bearing animals.Cancer Treat Rep 70, 1433 (1986).
Chlebowski R T, Dietrich M, Akman S, Block J B: Vitamin K3 inhibition of malignant murine cell growth and human tumor colony formation.Cancer Treat Rep 69, 527 (1985).
Miasishcheva N V, Gerasimova G K: Vliianie metil-kobalamina na trasport metotreksata v norma nye i opukholevye tkani.Bull Eksp Biol Med 99, 736 (1985).
Fortmeyer H P, Timm C, Blum U, Wenisch H J C, Förster H: Vitamin B6 responsive growth of human tumors.Anticancer Res 8, 813 (1988).
Okunieff P, Suit H D: Toxicity, radiation sensitivity modification, and combined drug effects of ascorbic acid with misonidazolein vivo on FSaII murine fibrosarcoma.JNCI 79, 377 (1987).
Yang T N, Ren C F, Pan H Q, Wang J L, Zhang Z Y, Su C H: Effect of vitamin C on thermal sensitivity of Lewis tumor.Chung Hua Chung Liu Tsa Chih 9, 421 (1987).
Chiou S H, Ohtsu N: Antiproliferative and DNA scission activities of L-ascorbic acid in the presence of copper chelates.Proc natn Sci Council Repub China 9, 275 (1985).
Taper H S, de Gerlache J, Lans M, Roberfroid M: Non-toxic potentiation of cancer chemotherapy by combined C and K3 vitamin pre-treatment.Int J Cancer 40, 575 (1987).
Cervantes A, Pinedo H M, Lankelma J, Schuurhuis G J: The role of oxygen derived free radicals in the cytotoxicity of doxorubicin in multidrug resistant and sensitive human ovarian cancer cells.Cancer Lett 41, 169 (1988).
Begin M E, Ells G, Horrobin D F: Polyunsaturated fatty acidoinduced cytotoxicity against tumor cells and its relationship to lipid peroxidation.J natn Cancer Inst 80, 188 (1988).
Said H M, Hollander D: Inhibitory effect of bile salts on the enterohepatic circulation of methotrexate in the unanesthetized rat: inhibition of methotrexate intestinal absorption.Cancer Chemother Pharmacol 16, 121 (1986).
Henriksson R, Franzén L, Littbrand B: Prevention of irradiation induced bowel discomfort: A double blind placebo controlled study when treating pelvic cancer.Am J Medicine (in press).
Pozner J, Papatestas A E, Fagerström R, Schwartz I, Saevitz J, Feinberg M, Aufses A H: Association of tumor differentiation with caffeine and coffee intake in women with breast cancer.Surgery 100, 482 (1986).
Timson J: Caffeine.Muta Res 47, 1 (1977).
Cohen M H: Enhancement of the antitumor effect of l,3-bis(2-chloroethyl)-l-nitrosourea by various psychotropic drugs in combination with caffeine.J Pharmac exp Ther 194, 475 (1975).
Osieka R, Glatte P, Pannenbäcker R, Schmidt C G: Enhancement of semustine-induced cytotoxicity by chlorpromazine and caffeine in a human melanoma xenograft.Cancer Treat Rep 70, 1167 (1986).
Allen T E, Aliano N A, Cowan R J, Grigg G W, Hart N K, Lamberton J A, Lane A: Amplification of the antitumor activity of phleomycins and bleomycins in rats and mice by caffeine.Cancer Res 45, 2516 (1985).
Basu T, Bishun N P, Williams D: Accentuation of the cell-killing effects of chlorambucil by phenobarbital, caffeine and vitamin A in culture.Cytobios 9, 115 (1974).
Fraval H N, Roberts J J: Effects of cis-platinum (II) diaminedichloride on survival and the rate of DNA synthesis in synchronously growing Chinese hamster V79-379A cells in the absence and presence of caffeine inhibited post-replication repair; evidence for an inducible repair mechanism.Chem Biol Interact 23, 99 (1978).
Orstavik J: Caffeine sensitive recovery of mitomycin C treated mouse P-388 cells.Acta Pathol Microbiol Scand 80, 900 (1972).
Murnane J P, Byfield J E, Ward J F, Calabro-Jones, P: Effects of methylated xanthines on mammalian cells treated with bifunctional alkylating agents.Nature 285, 326 (1980).
Walker I G, Reid B D: Caffeine potentiation of the lethal action of alkylating agents on L-cells.Mutat Res 12, 101 (1971).
Cohen M H, Schoenfeld D, Wolter J: Randomized trial of chlorpromazine, caffeine, and methyl-CCNU in disseminated melanoma.Cancer Treat Rep 64, 151 (1980).
Kyle R A, Seligman B R, Wallace H J Jr,et al.: Multiple myeloma resistant to melphalan (NSC-8806) treated with cyclophosphamide (NSC-26271), prednisone (NSC-10023), and chloroquine (NSC-187208).Cancer Chemother Rep 59, 557 (1975).
Daley-Yates P T, McBrien D C H: A study of the protective effect of chloride salts on cisplatin nephrotoxicity.Biochem Pharmac 34, 2363 (1985).
Takiyama W, Hirai T, iMiyoshi Y, Yoshihara T, Hattori T: Enhanced antitumor effects of bleomycin and moderate hyperthermia by additional use of ethanol.Jap J Surgery 14, 262.
Tobias H, Auerbach R: Hepatotoxicity of a long-term methotrexate therapy for psoriasis.Arch Intern Med 132, 391 (1973).
Balducci L, Philips M, Wallace C, Hardy C: Cancer chemotherapy in the elderly.Am Family Phys 35, 133 (1987).
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Henriksson, R., Rogo, K.O. & Grankvist, K. Interaction between cytostatics and nutrients. Med. Oncol. & Tumor Pharmacother. 8, 79–86 (1991). https://doi.org/10.1007/BF02988858
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DOI: https://doi.org/10.1007/BF02988858