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Pharmacologic activities of copper compounds in chronic diseases

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Abstract

Copper complexes have been shown to be effective antiinflammatory, antiulcer, anticonvulsant, anticancer, and antidiabetic agents. This seemingly diverse variety of pharmacologic effects is unified by the hypothesis that copper complexes facilitate or promote tissue repair processes involving copper-dependent enzymes and that arthritis, ulcers, seizures, neoplasia, and diabetes are diseases of specific tissues in disrepair. The corollary to this hypothesis is that the loss or reduction of copper-dependent enzyme-mediated processes leads to tissue dysfunction that may be reversed with copper complex therapy.

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Author information

Authors and Affiliations

  1. Department of Biopharmaceutical Sciences, College of Pharmacy, USA

    John R. J. Sorenson, Vimal Kishore & Abbas Pezeshk

  2. Department of Pharmacology, College of Medicine, University of Arkansas for Medical Sciences, USA

    John R. J. Sorenson

  3. Radiation Research Laboratory, University of Iowa, USA

    Larry W. Oberley & Susan W. C. Leuthauser

  4. Department of Opthalmology, Medical University of South Carolina, USA

    Rosalie K. Crouch

  5. Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, USA

    Thomas W. Kensler

  6. Department of Pathology, College of Medicine, University of Wisconsin, USA

    Terry D. Oberley

Authors
  1. John R. J. Sorenson
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  2. Larry W. Oberley
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  3. Rosalie K. Crouch
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  4. Thomas W. Kensler
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  5. Vimal Kishore
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  6. Susan W. C. Leuthauser
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  7. Terry D. Oberley
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  8. Abbas Pezeshk
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Sorenson, J.R.J., Oberley, L.W., Crouch, R.K. et al. Pharmacologic activities of copper compounds in chronic diseases. Biol Trace Elem Res 5, 257–273 (1983). https://doi.org/10.1007/BF02987212

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  • DOI: https://doi.org/10.1007/BF02987212

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