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In vitro inhibition by mammal erythrocytes on erythropoiesis

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Abstract

Packed mammal erythrocytes of the same mass but characterised by different mean corpuscolar volumes (MCV) were incubated. The influence of these conditioned media (ECM) on59Fe uptake into haem in cultures of guinea-pig bone-marrow cells was studied. The present results demonstrate that ram erythrocyte ECM (MCV = 28) caused a more marked in vitro depression of haeme synthesis than did calf (MCV = 34) and guinea pig (MCV = 69) erythrocyte ECM and that this inhibitory effect is correlated to the MCV of the erythrocytes considered.

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References

  • Aleporou V, Maclean N (1978) Feedback inhibition of erythropoiesis induced in anaemicXenopus. J Embryol Exp Morphol 43:221–231

    PubMed  CAS  Google Scholar 

  • Bateman A, Pollock K (1977) Effects of erythrocyte lysate and erythrocyte-conditioned medium on erythroid cells in vitro. Virchows Arch [Cell Path] 25:171–177

    CAS  Google Scholar 

  • Cole RJ, Regan T (1977) Regulation of pre-natal haemopoiesis: evidence for negative feedback control of erythropoiesis in the foetal mouse. J Embryol Exp Morphol 37:237–249

    PubMed  CAS  Google Scholar 

  • Goldwasser E, Eliason JF, Sikkema D (1975) An assay for erythropoietin in vitro at the milliunit level. Endocrinology 97:315–323

    PubMed  CAS  Google Scholar 

  • Michailov VV, Neustroev GV (1980) A role of the sympathetic nervous system in regulating the production of erythrocytic chalone. Fiziol Zh SSSR 66:1344–1349

    Google Scholar 

  • Perrins JDD, Jones WA (1981) An assay for erythrocyte chalone using chick embryo red blood cells. Acta Haematol 65:247–252

    Article  PubMed  CAS  Google Scholar 

  • Reynafajre CH (1968) Humoral regulation of the erythropoietic depression of high altitude polycythemic subjects after return to sea level. Ann NY Acad Sci 149:472–474

    Article  Google Scholar 

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Authors and Affiliations

  1. Institute of Comparative Anatomy, Via L. Borsari 46, 44100, Ferrara, Italy

    M. Vedovato, G. Salvatorelli & R. Calza

Authors
  1. M. Vedovato
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  2. G. Salvatorelli
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  3. R. Calza
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Vedovato, M., Salvatorelli, G. & Calza, R. In vitro inhibition by mammal erythrocytes on erythropoiesis. Comp Haematol Int 2, 56–57 (1992). https://doi.org/10.1007/BF02984529

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  • DOI: https://doi.org/10.1007/BF02984529

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